ADAR1 Editing and its Role in Cancer

A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer

(2018) Xinxin Peng et al.   CANCER CELL

Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

(2018) Hachung Chung et al.   CELL

Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation

(2018) Sadeem Ahmad et al.   CELL

Decreased A-to-I RNA editing as a source of keratinocytes' dsRNA in psoriasis

(2018) Lea Shallev et al.   RNA

ADARs and editing: The role of A-to-I RNA modification in cancer progression

(2018) Kajsa Fritzell et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ADAR1-mediated regulation of melanoma invasion

(2018) Yael Nemlich et al.   Nature Communications

A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression

(2018) Guermarie Velazquez-Torres et al.   Nature Communications

Aberrant hyperediting of the myeloma transcriptome by ADAR1 confers oncogenicity and is a marker of poor prognosis

(2018) Phaik Ju Teoh et al.   BLOOD

RNA editing of Filamin A pre‐mRNA regulates vascular contraction and diastolic blood pressure

(2018) Mamta Jain et al.   EMBO JOURNAL

RNA editing derived epitopes function as cancer antigens to elicit immune responses

(2018) Minying Zhang et al.   Nature Communications

Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers

(2017) Yumeng Wang et al.   GENOME RESEARCH

Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma

(2017) Eimile Oakes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer

(2017) Masataka Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

(2017) Robert T. Manguso et al.   NATURE

The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizingFAK

(2017) Elianna M. Amin et al.   Science Signaling

ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer

(2017) In Hye Song et al.   TUMOR BIOLOGY

RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers

(2017) Xueda Hu et al.   TUMOR BIOLOGY

Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma

(2017) Elisa Lazzari et al.   Nature Communications

A-to-I RNA editing of BLCAP lost the inhibition to STAT3 activation in cervical cancer

(2017) Wen Chen et al.   Oncotarget

Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

(2017) Yize Li et al.   eLife

The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizingFAK

(2017) Elianna M. Amin et al.   Science Signaling

RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages

(2017) Maria Pujantell et al.   Scientific Reports

ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis

(2016) Maria Anna Zipeto et al.   Cell Stem Cell

Ubiquitin-dependent Turnover of Adenosine Deaminase Acting on RNA 1 (ADAR1) Is Required for Efficient Antiviral Activity of Type I Interferon

(2016) Lemin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis

(2016) Kiranmai Gumireddy et al.   Nature Communications

ADAR1 Suppresses the Activation of Cytosolic RNA-Sensing Signaling Pathways to Protect the Liver from Ischemia/Reperfusion Injury

(2016) Hui Wang et al.   Scientific Reports

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

(2015) Leng Han et al.   CANCER CELL

RNA over-editing of BLCAP contributes to hepatocarcinogenesis identified by whole-genome and transcriptome sequencing

(2015) Xueda Hu et al.   CANCER LETTERS

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis

(2015) Einav Shoshan et al.   NATURE CELL BIOLOGY

Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis

(2015) C Anadón et al.   ONCOGENE

PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNAPCA3

(2015) Ahmad Salameh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme

(2015) Gilli Galore-Haskel et al.   Oncotarget

Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors

(2015) Nurit Paz-Yaacov et al.   Cell Reports

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome

(2015) Debora Fumagalli et al.   Cell Reports

Adenosine Deaminase Acting on RNA 1 Limits RIG-I RNA Detection and Suppresses IFN Production Responding to Viral and Endogenous RNAs

(2014) Shengyong Yang et al.   JOURNAL OF IMMUNOLOGY

Human breast cancer metastases to the brain display GABAergic properties in the neural niche

(2014) J. Neman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma

(2013) Y.-R. Qin et al.   CANCER RESEARCH

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes

(2013) L. Bazak et al.   GENOME RESEARCH

A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma

(2013) Tim Hon Man Chan et al.   GUT

MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth

(2013) Yael Nemlich et al.   JOURNAL OF CLINICAL INVESTIGATION

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma

(2013) Leilei Chen et al.   NATURE MEDICINE

RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling

(2013) Takashi Shimokawa et al.   RNA Biology

Stress Granule Formation Induced by Measles Virus Is Protein Kinase PKR Dependent and Impaired by RNA Adenosine Deaminase ADAR1

(2012) K. M. Okonski et al.   JOURNAL OF VIROLOGY

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

(2012) Bradley N Bidwell et al.   NATURE MEDICINE

Emerging molecular targets in melanoma invasion and metastasis

(2012) Jose L. Orgaz et al.   Pigment Cell & Melanoma Research

Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

(2011) A. Peisley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The synapse and cytolytic machinery of cytotoxic T cells

(2010) Misty R Jenkins et al.   CURRENT OPINION IN IMMUNOLOGY

Human BLCAP transcript: new editing events in normal and cancerous tissues

(2010) Federica Galeano et al.   INTERNATIONAL JOURNAL OF CANCER

Adenosine-to-Inosine RNA Editing Affects Trafficking of the γ-Aminobutyric Acid Type A (GABAA) Receptor

(2010) Chammiran Daniel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation

(2010) Perrine Pinon et al.   Pigment Cell & Melanoma Research

RNA-Regulated Interaction of Transportin-1 and Exportin-5 with the Double-Stranded RNA-Binding Domain Regulates Nucleocytoplasmic Shuttling of ADAR1

(2009) J. Fritz et al.   MOLECULAR AND CELLULAR BIOLOGY

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

(2008) Jochen C Hartner et al.   NATURE IMMUNOLOGY