The Molecular and Neuropathological Consequences of Genetic Risk for Alzheimer's Dementia

Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages

(2018) Jaeyoon Chung et al.   Alzheimers & Dementia

Person-specific contribution of neuropathologies to cognitive loss in old age

(2018) Patricia A. Boyle et al.   ANNALS OF NEUROLOGY

Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia

(2018) Lei Yu et al.   ANNALS OF NEUROLOGY

Gene expression and DNA methylation are extensively coordinated with MRI-based brain microstructural characteristics

(2018) Chris Gaiteri et al.   Brain Imaging and Behavior

Religious Orders Study and Rush Memory and Aging Project

(2018) David A. Bennett et al.   JOURNAL OF ALZHEIMERS DISEASE

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

(2018) Sara Mostafavi et al.   NATURE NEUROSCIENCE

Synaptic proteins in CSF as potential novel biomarkers for prognosis in prodromal Alzheimer’s disease

(2018) Flora H. Duits et al.   Alzheimers Research & Therapy

Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study

(2018) Hyun-Sik Yang et al.   LANCET NEUROLOGY

Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

(2018) Daniel Felsky et al.   Molecular Neurodegeneration

Multi-omic Directed Networks Describe Features of Gene Regulation in Aged Brains and Expand the Set of Genes Driving Cognitive Decline

(2018) Shinya Tasaki et al.   Frontiers in Genetics

Feature Selection with the R Package MXM: Discovering Statistically Equivalent Feature Subsets

(2017) Vincenzo Lagani et al.   Journal of Statistical Software

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer’s disease

(2017) Ellis Patrick et al.   Molecular Neurodegeneration

Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies

(2017) L B Chibnik et al.   MOLECULAR PSYCHIATRY

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats

(2017) David Brocks et al.   NATURE GENETICS

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

(2017) Bernard Ng et al.   NATURE NEUROSCIENCE

Polygenic score prediction captures nearly all common genetic risk for Alzheimer's disease

(2017) Valentina Escott-Price et al.   NEUROBIOLOGY OF AGING

Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery

(2017) David A. Bennett   PLOS MEDICINE

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

(2017) Rahul S. Desikan et al.   PLOS MEDICINE

POLYGENIC RISK OF ALZHEIMER’S DISEASE IS ASSOCIATED WITH EARLY AND LATE LIFE PROCESSES

(2016) Elizabeth C. Mormino et al.   Alzheimers & Dementia

Genetic variants in Alzheimer disease — molecular and brain network approaches

(2016) Chris Gaiteri et al.   Nature Reviews Neurology

Relation of genomic variants for Alzheimer disease dementia to common neuropathologies

(2016) Jose M. Farfel et al.   NEUROLOGY

Coding mutations inSORL1and Alzheimer disease

(2015) Badri N. Vardarajan et al.   ANNALS OF NEUROLOGY

LOLA: enrichment analysis for genomic region sets and regulatory elements in R and Bioconductor

(2015) Nathan C. Sheffield et al.   BIOINFORMATICS

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

GWAS of longitudinal amyloid accumulation on18F-florbetapir PET in Alzheimer’s disease implicates microglial activation geneIL1RAP

(2015) Vijay K Ramanan et al.   BRAIN

Mouse models rarely mimic the transcriptome of human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models

(2015) Terry C. Burns et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span

(2015) Mintie Pu et al.   GENES & DEVELOPMENT

H3K36 methylation promotes longevity by enhancing transcriptional fidelity

(2015) Payel Sen et al.   GENES & DEVELOPMENT

VGF and Its C-Terminal Peptide TLQP-62 Regulate Memory Formation in Hippocampus via a BDNF-TrkB-Dependent Mechanism

(2015) W.-J. Lin et al.   JOURNAL OF NEUROSCIENCE

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

Association of Alzheimer's disease GWAS loci with MRI markers of brain aging

(2015) Ganesh Chauhan et al.   NEUROBIOLOGY OF AGING

Temporal course and pathologic basis of unawareness of memory loss in dementia

(2015) Robert S. Wilson et al.   NEUROLOGY

Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume and Functional Connectivity in Young Healthy Individuals

(2015) Xiaolong Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Identifying robust communities and multi-community nodes by combining top-down and bottom-up approaches to clustering

(2015) Chris Gaiteri et al.   Scientific Reports

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

(2014) Martin J. Aryee et al.   BIOINFORMATICS

PRSice: Polygenic Risk Score software

(2014) Jack Euesden et al.   BIOINFORMATICS

Coding variants in TREM2 increase risk for Alzheimer's disease

(2014) Sheng Chih Jin et al.   HUMAN MOLECULAR GENETICS

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

(2014) Valentina Escott-Price et al.   PLoS One

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

(2014) T. Raj et al.   SCIENCE

VGF (TLQP-62)-induced neurogenesis targets early phase neural progenitor cells in the adult hippocampus and requires glutamate and BDNF signaling

(2014) Smita Thakker-Varia et al.   Stem Cell Research

Assessing the utility of intermediate phenotypes for genetic mapping of psychiatric disease

(2014) Jonathan Flint et al.   TRENDS IN NEUROSCIENCES

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Much of late life cognitive decline is not due to common neurodegenerative pathologies

(2013) Patricia A. Boyle et al.   ANNALS OF NEUROLOGY

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Overview and Findings from the Religious Orders Study

(2013) David A. Bennett et al.   Current Alzheimer Research

Overview and Findings from the Rush Memory and Aging Project

(2013) David A. Bennett et al.   Current Alzheimer Research

Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders

(2013) C. Gaiteri et al.   GENES BRAIN AND BEHAVIOR

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease

(2013) Carlos Cruchaga et al.   NATURE

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Impaired default network functional connectivity in autosomal dominant Alzheimer disease

(2013) J. P. Chhatwal et al.   NEUROLOGY

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alzheimer’s Disease: Analyzing the Missing Heritability

(2013) Perry G. Ridge et al.   PLoS One

Genes and pathways underlying regional and cell type changes in Alzheimer's disease

(2013) Jeremy A Miller et al.   Genome Medicine

Genetic Susceptibility for Alzheimer Disease Neuritic Plaque Pathology

(2013) Joshua M. Shulman et al.   JAMA Neurology

Relation of neuropathology to cognition in persons without cognitive impairment

(2012) David A. Bennett et al.   ANNALS OF NEUROLOGY

Matrix eQTL: ultra fast eQTL analysis via large matrix operations

(2012) A. A. Shabalin   BIOINFORMATICS

Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies

(2012) J. A. Schneider et al.   BRAIN

Impairment of Catecholamine Systems during Induction of Long-Term Potentiation at Hippocampal CA1 Synapses in HPC-1/Syntaxin 1A Knock-out Mice

(2012) T. Mishima et al.   JOURNAL OF NEUROSCIENCE

Label-Free Quantitative LC–MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains

(2012) Victor P. Andreev et al.   JOURNAL OF PROTEOME RESEARCH

Animal systems in the development of treatments for Alzheimer's disease: challenges, methods, and implications

(2012) Jonathan J. Sabbagh et al.   NEUROBIOLOGY OF AGING

The Association between a Polygenic Alzheimer Score and Cortical Thickness in Clinically Normal Subjects

(2011) Mert R. Sabuncu et al.   CEREBRAL CORTEX

Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

(2011) Shitao Li et al.   IMMUNITY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

Intelligence in Williams Syndrome Is Related to STX1A, Which Encodes a Component of the Presynaptic SNARE Complex

(2010) Michael C. Gao et al.   PLoS One

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

(2010) Daniele Merico et al.   PLoS One

microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus

(2010) S. T. Magill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Unified Approach to Genotype Imputation and Haplotype-Phase Inference for Large Data Sets of Trios and Unrelated Individuals

(2009) Brian L. Browning et al.   AMERICAN JOURNAL OF HUMAN GENETICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Mapping protein abundance patterns in the brain using voxelation combined with liquid chromatography and mass spectrometry

(2009) Vladislav A. Petyuk et al.   METHODS

Reviews: Mechanisms Mediating Brain Plasticity: IGF1 and Adult Hippocampal Neurogenesis

(2009) María LLorens-Martín et al.   NEUROSCIENTIST

Distinct patterns of brain activity in young carriers of the APOE- 4 allele

(2009) N. Filippini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY