Article
Multidisciplinary Sciences
Julian Heuberger, Johanna Grinat, Frauke Kosel, Lichao Liu, Severine Kunz, Ramon Oliveira Vidal, Marlen Keil, Johannes Haybaeck, Sylvie Robine, Daniel Louvard, Christian Regenbrecht, Anje Sporbert, Sascha Sauer, Bjorn von Eyss, Michael Sigal, Walter Birchmeier
Summary: Mutations disrupting the renewal processes of intestinal epithelial cells may contribute to tumorigenesis. Activation of Notch signaling and ablation of p53 induce a highly proliferative and regenerative cell state in intestinal organoids. Yap and Mll1 are elevated in patient-derived colorectal cancer organoids, controlling growth and viability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Ke Zheng, Nannan Sha, Guofang Hou, Zhuyun Leng, Qin Zhao, Li Zhang, Lingnan He, Meidong Xu, Yuhui Jiang, Tao Chen
Summary: This study reveals that phosphorylation of PYCR1 under hypoxia promotes its binding to ELK4, which is involved in the regulation of tumor growth and is associated with malignancy of colorectal cancer (CRC).
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Viktorija Juric, Lance Hudson, Joanna Fay, Cathy E. Richards, Hanne Jahns, Maite Verreault, Franck Bielle, Ahmed Idbaih, Martine L. M. Lamfers, Ann M. Hopkins, Markus Rehm, Brona M. Murphy
Summary: The activation of CDKs contributes to the uncontrolled proliferation of tumor cells, such as in the case of GBM. In this study, two CDK inhibitors, CYC065 and THZ1, showed promising therapeutic efficacy in GBM patient-derived cell lines, suppressing invasion and inducing cell death. These novel CKIs have the potential to be further investigated for clinical applications in the treatment of GBM.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Lei Liu, Tianyu Tao, Shihua Liu, Xia Yang, Xuwei Chen, Jiaer Liang, Ruohui Hong, Wenting Wang, Yi Yang, Xiaoyi Li, Youhong Zhang, Quanfeng Li, Shujun Liang, Haocheng Yu, Yun Wu, Xinyu Guo, Yan Lai, Xiaofan Ding, Hongyu Guan, Jueheng Wu, Xun Zhu, Jie Yuan, Jun Li, Shicheng Su, Mengfeng Li, Xiuyu Cai, Junchao Cai, Han Tian
Summary: The study reveals that the positive feedback loop between RFC4 and NICD1 plays a critical role in linking NSCLC metastasis and stemness properties, with potential therapeutic and diagnostic/prognostic implications for NSCLC therapy.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Liyuan Zhang, Yue Dong, Luxin Zhang, Minjun Wang, Ye Zhou, Kaiwei Jia, Suyuan Wang, Mu Wang, Yunhui Li, Shudan Luo, Shan Lu, Yiwen Fan, Dingji Zhang, Yingyun Yang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou
Summary: This study found that the expression of IRG1 is upregulated in the process of hepatocarcinogenesis, and it promotes hepatocyte apoptosis and liver damage, thus enhancing the development of hepatocellular carcinoma. Mechanistically, mitochondrial IRG1 can associate with anti-apoptotic MCL-1, promoting the activation of Bim and translocation of Bax in the mitochondria, and initiating apoptosis. These findings provide a potential target for preventing liver injury and hepatocellular carcinoma.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Sathyen A. Prabhu, Omar Moussa, Christophe Goncalves, Judith H. LaPierre, Hsiang Chou, Fan Huang, Vincent R. Richard, Pault Y. M. Ferruzo, Elizabeth M. Guettler, Isabel Soria-Bretones, Laura Kirby, Natascha Gagnon, Jie Su, Jennifer Silvester, Sai Sakktee Krisna, April A. N. Rose, Karen E. Sheppard, David W. Cescon, Frederick A. Mallette, Rene P. Zahedi, Christoph H. Borchers, Sonia V. del Rincon, Wilson H. Miller Jr
Summary: This article investigates the use of CDK4/6 inhibitor palbociclib in melanoma and finds that the treatment induces phosphorylation of eIF4E, leading to increased translation of proteins involved in cell survival and evasion of the drug's antitumor effects.
MOLECULAR CANCER THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Anja C. Nagel, Dominik Mueller, Mirjam Zimmermann, Anette Preiss
Summary: The membrane-bound Notch regulator (Mnr) supports Notch signaling by promoting the cleavage of the Notch receptor, which in turn enhances Notch receptor activation. Overexpression of Mnr stimulates γ-secretase activity, while knockdown of Mnr inhibits this activity, demonstrating Mnr as a positive regulator of Notch signaling.
Article
Immunology
Qiong Luo, Yijun Liu, Ke Shi, Xuecheng Shen, Yaqi Yang, Xuejiao Liang, Liangliang Lu, Wenxuan Qiao, Airu Chen, Dongmei Hong, Yang Sun, Qiang Xu
Summary: IL-17 therapy has limited efficacy in autoimmune diseases, and a molecular complex containing SHP2 and Act1 mediates an alternative pathway for IL-17R signaling, which could be a therapeutic option for IL-17-related diseases.
Article
Biology
Justine M. Pinskey, Tyler M. Hoard, Xiao-Feng Zhao, Nicole E. Franks, Zoe C. Frank, Alexandra N. McMellen, Roman J. Giger, Benjamin L. Allen
Summary: Hedgehog signaling is crucial throughout the life of an organism, and this study reveals Plexin as a novel component of this pathway and investigates its functionality and mechanism of action.
Article
Oncology
Haoming Chen, Ravi Padia, Tao Li, Yue Li, Bin Li, Lingtao Jin, Shuang Huang
Summary: Triple negative breast cancer cells have higher AP1 activity, regulated by the p38(MAPK) signaling pathway. MK2-mediated phosphorylation of JAB1 facilitates JUN recruitment to AP1 sites, enhancing AP1 activity.
Article
Biochemistry & Molecular Biology
Brigitte Bauvois, Elodie Pramil, Ludovic Jondreville, Claire Quiney, Florence Nguyen-Khac, Santos A. Susin
Summary: The study reveals that both type I and II interferons promote survival of chronic lymphocytic leukemia cells by activating the STAT3/Mcl-1 signaling pathway, inhibiting intrinsic apoptosis. Inhibitors against STAT3, TYK2 (for type I IFN), JAK2 (for type II IFN), and Src family kinase PP2 can effectively reduce interferon-mediated cell survival. Combining conventional treatments with inhibitors targeting STAT3 and Mcl-1 may offer a new therapeutic strategy for CLL.
Article
Medicine, Research & Experimental
Ryan C. Gimple, Guoxin Zhang, Shuai Wang, Tengfei Huang, Jina Lee, Suchet Taori, Deguan Lv, Deobrat Dixit, Matthew E. Halbert, Andrew R. Morton, Reilly L. Kidwell, Zhen Dong, Briana C. Prager, Leo J. Y. Kim, Zhixin Qiu, Linjie Zhao, Qi Xie, Qiulian Wu, Sameer Agnihotri, Jeremy N. Rich
Summary: In this study, the researchers found that SNX10 was selectively expressed in glioblastoma stem cells (GSCs) compared with non-neoplastic neural stem cells (NSCs). SNX10 was essential for GSC survival and promoted GSC proliferation and stem cell signaling pathways through posttranscriptional regulation of PDGFR tyrosine kinase. Targeting SNX10 expression decreased GSC viability and self-renewal capacity. High expression of SNX10 correlated with poor prognosis in glioblastoma patients.
Article
Immunology
Tiankui Ma, Xin Li, Yonghong Zhu, Shufan Yu, Tianyan Liu, Xiaodan Zhang, Dong Chen, Shuyan Du, Tong Chen, Shuo Chen, Yanyan Xu, Qiuling Fan
Summary: This study provides new insights into the role of monocytes/macrophages in the progression of diabetic nephropathy and highlights the crosstalk between the Notch pathway and NF-kappa B signaling in macrophages. The findings suggest that modulation of macrophage polarization and inhibition of the Notch pathway could be potential therapeutic strategies for diabetic nephropathy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pan Pan, Weiwei Ge, Zhiwei Lei, Wei Luo, Yuqing Liu, Zhanwen Guan, Lumiao Chen, Zhenyang Yu, Miaomiao Shen, Dingwen Hu, Qi Xiang, Wenbiao Wang, Pin Wan, Mingfu Tian, Yang Yu, Zhen Luo, Xulin Chen, Heng Xiao, Qiwei Zhang, Xujing Liang, Xin Chen, Yongkui Li, Jianguo Wu
Summary: A study reveals that SARS-CoV-2 employs a distinctive anti-apoptotic mechanism through its N protein to suppress cell apoptosis, thereby promoting viral replication. This explains why SARS-CoV-2 can effectively replicate in asymptomatic individuals and indicates a risk of enhanced coinfection with other viruses.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Multidisciplinary Sciences
Diana Trnski, Maja Sabol, Sanja Tomic, Ivan Stefanac, Milanka Mrcela, Vesna Musani, Nikolina Rincic, Matea Kurtovic, Tina Petric, Sonja Levanat, Petar Ozretic
Summary: Prostate cancer is the second most frequent cancer in men worldwide, with different treatment strategies for localized versus advanced cases. Research suggests that the Hedgehog-GLI signaling pathway plays a crucial role in sustaining androgen-independent growth of prostate cancer cells.
SCIENTIFIC REPORTS
(2021)
