Hypoxia-inducible Factor-1 (HIF-1) but Not HIF-2 Is Essential for Hypoxic Induction of Collagen Prolyl 4-Hydroxylases in Primary Newborn Mouse Epiphyseal Growth Plate Chondrocytes

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival

(2011) Christa Maes et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development

(2011) Elisa Araldi et al.   NATURE MEDICINE

Hypoxia, HIFs and bone development

(2010) Elisa Araldi et al.   BONE

Inhibition of Hypoxia-inducible Factor-targeting Prolyl Hydroxylase Domain-containing Protein 2 (PHD2) Enhances Matrix Synthesis by Human Chondrocytes

(2010) Brendan L. Thoms et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Hypoxia-inducible factor 1α inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: Hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1α-dependent redifferentiation of chondrocytes

(2009) Elise Duval et al.   ARTHRITIS AND RHEUMATISM

Extracellular matrix genes as hypoxia-inducible targets

(2009) Johanna Myllyharju et al.   CELL AND TISSUE RESEARCH

HIF Prolyl 4-Hydroxylases and their Potential as Drug Targets

(2009) Johanna Myllyharju   CURRENT PHARMACEUTICAL DESIGN

Localization of erythropoietin in and around growing cartilage

(2009) Ward De Spiegelaere et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

(2008) Johanna Myllyharju   ANNALS OF MEDICINE

Hypoxia-inducible factor: roles in development, physiology and disease

(2008) N S Chandel et al.   CELL DEATH AND DIFFERENTIATION

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL