AMP-activated protein kinase: Structure, function, and role in pathological processes

Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke

(2014) Venugopal R. Venna et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: Interference of AMPK/PGC-1α pathway

(2014) Ghorbangol Ashabi et al.   METABOLIC BRAIN DISEASE

Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells

(2013) Chia-Chi Hsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

LKB1 and AMPK and the cancer-metabolism link - ten years after

(2013) D Hardie et al.   BMC BIOLOGY

Glucose promotes breast cancer aggression and reduces metformin efficacy

(2013) Reema Wahdan-Alaswad et al.   CELL CYCLE

AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer

(2013) D. G. Hardie   DIABETES

Synthesis and Mechanism of Hypoglycemic Activity of Benzothiazole Derivatives

(2013) Ella Meltzer-Mats et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Conserved regulatory elements in AMPK

(2013) Lei Chen et al.   NATURE

(ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson’s disease

(2013) T W Kim et al.   Cell Death & Disease

Discovery of Pyridones As Oral AMPK Direct Activators

(2013) Olivier Mirguet et al.   ACS Medicinal Chemistry Letters

Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators

(2013) Li-Fang Yu et al.   ACS Medicinal Chemistry Letters

N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells

(2012) Toko Chida et al.   BIOCHEMICAL JOURNAL

AMP-Activated Protein Kinase β-Subunit Requires Internal Motion for Optimal Carbohydrate Binding

(2012) Michael Bieri et al.   BIOPHYSICAL JOURNAL

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

(2012) D. Grahame Hardie et al.   CHEMISTRY & BIOLOGY

Metformin interacts with AMPK through binding to γ subunit

(2012) Yaya Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

AMPK and the neuroendocrine regulation of appetite and energy expenditure

(2012) Romana Stark et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK

(2012) Yu-yi Lin et al.   NATURE

AMP-activated protein kinase undergoes nucleotide-dependent conformational changes

(2012) Lei Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neurites

(2012) Peizhou Jiang et al.   NEUROBIOLOGY OF AGING

Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain

(2011) Noriko Handa et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Sanguinarine is an allosteric activator of AMP-activated protein kinase

(2011) Jiwon Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: Implication of the cell survival in mitochondrial diseases

(2011) Shi-Bei Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase

(2011) Faith V. Mayer et al.   Cell Metabolism

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

The AMPK/SNF1/SnRK1 fuel gauge and energy regulator: structure, function and regulation

(2011) Ruben Ghillebert et al.   FEBS Journal

Regulation of LKB1 expression by sex hormones in adipocytes

(2011) K J McInnes et al.   INTERNATIONAL JOURNAL OF OBESITY

Suppression of 5′-Nucleotidase Enzymes Promotes AMP-activated Protein Kinase (AMPK) Phosphorylation and Metabolism in Human and Mouse Skeletal Muscle

(2011) Sameer S. Kulkarni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A small molecule AMPK activator protects the heart against ischemia–reperfusion injury

(2011) Agnes S. Kim et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

LKB1 expression is inhibited by estradiol-17β in MCF-7 cells

(2011) Kristy A. Brown et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels

(2011) P. T. Mungai et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

Structural Insights into the Architecture and Allostery of Full-Length AMP-Activated Protein Kinase

(2011) Li Zhu et al.   STRUCTURE

The Dynamical Mechanism of Auto-Inhibition of AMP-Activated Protein Kinase

(2011) Cheng Peng et al.   PLoS Computational Biology

An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1

(2010) Michael J. Rudolph et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation

(2010) Dene R. Littler et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

(2010) Valérie Vingtdeux et al.   ACTA NEUROPATHOLOGICA

The rational design of a novel potent analogue of the 5′-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular activity

(2010) Fouzia Machrouhi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SU11248 (sunitinib) directly inhibits the activity of mammalian 5'-AMP-activated protein kinase (AMPK)

(2010) Keith Laderoute et al.   CANCER BIOLOGY & THERAPY

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

Metformin Use and Mortality in Ambulatory Patients With Diabetes and Heart Failure

(2010) David Aguilar et al.   Circulation-Heart Failure

AMPK inhibition in health and disease

(2010) Benoit Viollet et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Diabetes and Cancer: A consensus report

(2010) E. Giovannucci et al.   DIABETES CARE

Metabolic functions of AMPK: Aspects of structure and of natural mutations in the regulatory gamma subunits

(2010) Cynthia Moffat et al.   IUBMB LIFE

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting AMPK for cardiac protection: Opportunities and challenges

(2010) Maengjo Kim et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Exercise-induced TBC1D1 Ser237 phosphorylation and 14-3-3 protein binding capacity in human skeletal muscle

(2010) Christian Frøsig et al.   JOURNAL OF PHYSIOLOGY-LONDON

Identification of a Nuclear Export Signal in the Catalytic Subunit of AMP-activated Protein Kinase

(2010) Nevzat Kazgan et al.   MOLECULAR BIOLOGY OF THE CELL

Adenosine monophosphate activated protein kinase inhibition is protective in both sexes after experimental stroke

(2010) Jun Li et al.   NEUROSCIENCE LETTERS

 -Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

(2010) J. S. Oakhill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Metformin in Experimental Stroke

(2010) Jun Li et al.   STROKE

Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells

(2009) Teayoun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor

(2009) Andrew McBride et al.   Cell Metabolism

Metformin Prevents Progression of Heart Failure in Dogs

(2009) Hideyuki Sasaki et al.   CIRCULATION

Sunitinib-Induced Cardiotoxicity Is Mediated by Off-Target Inhibition of AMP-Activated Protein Kinase

(2009) Risto Kerkela et al.   CTS-Clinical and Translational Science

The influence of glucose-lowering therapies on cancer risk in type 2 diabetes

(2009) C. J. Currie et al.   DIABETOLOGIA

Leptin-Stimulated Endothelial Nitric-Oxide Synthase via an Adenosine 5′-Monophosphate-Activated Protein Kinase/Akt Signaling Pathway Is Attenuated by Interaction with C-Reactive Protein

(2009) Cristina Procopio et al.   ENDOCRINOLOGY

Sunitinib in solid tumors

(2009) Hui K Gan et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

AMPK in the brain: its roles in energy balance and neuroprotection

(2009) Gabriele V. Ronnett et al.   JOURNAL OF NEUROCHEMISTRY

Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

(2009) Lei Chen et al.   NATURE

Ambivalent effects of compound C (dorsomorphin) on inflammatory response in LPS-stimulated rat primary microglial cultures

(2009) Krzysztof Łabuzek et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK

(2008) Danna M. Breen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways

(2008) Jiyun Ahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crucial role for LKB1 to AMPKα2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes☆

(2008) Daphna D.J. Habets et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes

(2008) John W. Scott et al.   CHEMISTRY & BIOLOGY

Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure

(2008) Susheel Gundewar et al.   CIRCULATION RESEARCH

AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5

(2008) S. L. McGee et al.   DIABETES

Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase

(2008) Han-Bing Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

AMP Activated Protein Kinase-α2 Deficiency Exacerbates Pressure-Overload–Induced Left Ventricular Hypertrophy and Dysfunction in Mice

(2008) Ping Zhang et al.   HYPERTENSION

Beyond AICA riboside: In search of new specific AMP-activated protein kinase activators

(2008) Bruno Guigas et al.   IUBMB LIFE

Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells

(2008) Tao Pang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Noveld-Xylose Derivatives Stimulate Muscle Glucose Uptake by Activating AMP-Activated Protein Kinase α

(2008) Arie Gruzman et al.   JOURNAL OF MEDICINAL CHEMISTRY

The anti-diabetic AMPK activator AICAR reduces IL-6 and IL-8 in human adipose tissue and skeletal muscle cells

(2008) Aina S. Lihn et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY