Article
Physiology
Songhan Li, Shuohui Dong, Qian Xu, Bowen Shi, Linchuan Li, Wenjie Zhang, Jiankang Zhu, Yugang Cheng, Guangyong Zhang, Mingwei Zhong
Summary: The study showed that sleeve gastrectomy has beneficial effects on mitochondrial homeostasis and cardiac injury in diabetic cardiomyopathy rats, improving myocardial function and restoring mitochondrial dysfunction through AMPK signaling activation-mediated suppression of NR4A1/DRP1.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Abhipree Sharma, Michael Mah, Rebecca H. Ritchie, Miles J. De Blasio
Summary: Diabetes is associated with an increased risk of heart failure known as diabetic cardiomyopathy. Adiponectin, a cardioprotective adipokine, is downregulated in diabetes and obesity, leading to reduced cardioprotection. This review summarizes the evidence linking suppressed adiponectin signaling pathway to cardiac dysfunction in diabetes and discusses potential therapeutic approaches for diabetic cardiomyopathy.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Chemistry, Medicinal
Xueyao Yang, Xin Zhao, Yanfei Liu, Yue Liu, Libo Liu, Ziyu An, Haoran Xing, Jinfan Tian, Xiantao Song
Summary: Studies showed that Ginkgo biloba extract (GBE) has a protective effect on the heart in diabetic conditions. The mechanisms underlying diabetic cardiomyopathy (DCM) include impaired autophagy. The study found that GBE improved DCM by restoring autophagy through modulating the AMPK/mTOR pathway.
PHYTOTHERAPY RESEARCH
(2023)
Review
Genetics & Heredity
Rimpi Saikia, Jomon Joseph
Summary: Autophagy is a cell survival strategy that helps cells maintain homeostasis by degrading and reusing cellular components under unfavorable conditions. It is regulated by AMPK and mTORC1, with AMPK activating autophagy in energy-deprived conditions and mTORC1 inhibiting autophagy in nutrient-rich conditions. Additionally, cytoplasmic calcium can also activate AMPK and autophagy through a calmodulin/CaMKK beta pathway, although the physiological significance of this regulation is still unclear.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Medicine, General & Internal
Zhe Zhang, Yunhan Tan, Canhua Huang, Xiawei Wei
Summary: DTP cells are a type of cells that can survive after exposure to anticancer drugs, and they enhance adaptive mutation by altering DNA repair mechanisms, resulting in the emergence of drug-resistant mutations. DTP cells maintain cellular homeostasis through metabolic reprogramming that promotes mitochondrial oxidative respiration and a robust antioxidant process, and they can resume proliferation after treatment withdrawal, leading to cancer relapse. Disrupting redox homeostasis by intervening with redox signaling is considered a promising therapeutic strategy. This review provides a comprehensive overview of the characteristics of DTP cells and the underlying mechanisms involved in redox signaling, aiming to offer a unique perspective on potential therapeutic applications based on their vulnerabilities to redox regulation.
Article
Cell Biology
Jingnan Liu, Xiaobo Wang, Rui Ma, Tianxia Li, Gongbo Guo, Bo Ning, Timothy H. Moran, Wanli W. Smith
Summary: Expression of synphilin-1 in neurons leads to hyperphagia and obesity in Drosophila models. The study found that AMP-activated kinase (AMPK) signaling pathway plays a critical role in synphilin-1-induced hyperphagia and obesity. Suppressing AMPK phosphorylation can reduce food intake and body weight gain induced by synphilin-1.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Chenyang Zhang, Huifang Yu, Jingxue Ye, Hongna Tong, Min Wang, Guibo Sun
Summary: Ginsenoside Rg3 extracted from Panax notoginseng has therapeutic effects on diabetes and heart diseases. This study investigated the mechanism of ginsenoside Rg3 on diabetic cardiomyopathy (DCM). The results showed that ginsenoside Rg3 improved adiponectin secretion and signaling, alleviated overweight, hyperglycemia, hyperlipidemia, and lipid accumulation and dysfunction in adipose, liver, and heart tissues. This research suggests that ginsenoside Rg3 may be a promising drug for treating diabetic cardiomyopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sunali Mehta, Hamish Campbell, Catherine J. Drummond, Kunyu Li, Kaisha Murray, Tania Slatter, Jean-Christophe Bourdon, Antony W. Braithwaite
Summary: p53 is a crucial protein in maintaining biological homeostasis, with its network playing a vital role in maintaining stability within multicellular organisms, facilitating cooperation between cells to adapt to environmental changes.
Article
Neurosciences
Xin Wang, Xueyan Zhou, Beth Uberseder, Jingyun Lee, Caitlin S. Latimer, Cristina M. Furdui, C. Dirk Keene, Thomas J. Montine, Thomas C. Register, Suzanne Craft, Carol A. Shively, Tao Ma
Summary: The study on NHP model demonstrated an increased activity of AMPK alpha 2 in AD-like neuropathology, unrelated to AMPK alpha 1; CSF Abeta(42) showed a negative correlation with cerebral amyloid plaque density; A beta plaque burden correlated with brain A beta measurement levels.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Sanket J. Mishra, Anuj Khandelwal, Monimoy Banerjee, Maurie Balch, Shuxia Peng, Rachel E. Davis, Taylor Merfeld, Vitumbiko Munthali, Junpeng Deng, Robert L. Matts, Brian S. J. Blagg
Summary: The study focuses on a new class of anti-cancer agents targeting Hsp90 protein - Hsp90 alpha-selective inhibitors, which demonstrate specificity and broad selectivity, showing promise for significant impact in cancer treatment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Qing-Bo Lu, Yi Ding, Yao Liu, Zi-Chao Wang, Yu-Jie Wu, Kai -Ming Niu, Ke-Xue Li, Ji -Ru Zhang, Hai-Jian Sun
Summary: Metrnl plays a protective role in diabetic cardiomyopathy and may serve as a therapeutic target or regimen.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Chemistry, Applied
Yi Wu, Minhua Zong, Zhenhui Zhang, Yongtai Wu, Lin Li, Xia Zhang, Hong Wu, Bing Li
Summary: This study identifies the selective transmembrane transport of different modification types of AGEs and their effects on cellular energy homeostasis. The results show that only certain types of free and peptide-bound AGEs can easily cross the cell membrane and exert their effects. Mechanistically, free AGEs interfere with mitochondrial function and energy production through the thymidine phosphorylase and AMPK-SIRT6 signaling pathways.
Review
Biochemistry & Molecular Biology
Antonio Jesus Lopez-Gambero, Fernando Rodriguez de Fonseca, Juan Suarez
Summary: Addiction involves repeated exposure and compulsive seeking of psychotropic drugs, leading to relapse despite harmful effects. Neuroadaptation mechanisms in reward circuits result in changes in neurotransmission and cellular structure, impacting neuronal energy balance and protein synthesis. Targeting metabolic sensors like AMPK and mTOR could lead to novel pharmacotherapies for individualized treatment of drug abuse.
Article
Multidisciplinary Sciences
Chenchen Zhu, Jingyan Wu, Han Sun, Francesca Briganti, Benjamin Meder, Wu Wei, Lars M. Steinmetz
Summary: The researchers identified disease-associated variant transcript isoforms through single-molecule full-length RNA sequencing and established a searchable, quantitative human transcriptome annotation. Their method allows for quantitative dissection of complex transcript architecture, providing more direct biological interpretation and higher resolution transcriptome comparisons.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yuan Liu, Michael J. Jurczak, Travis B. Lear, Bo Lin, Mads B. Larsen, Jason R. Kennerdell, Yanwen Chen, Brydie R. Huckestein, Matthew K. Nguyen, Ferhan Tuncer, Yu Jiang, Satdarshan P. Monga, Christopher P. O'Donnell, Toren Finkel, Bill B. Chen, Rama K. Mallampalli
Summary: A newly discovered compound, BC1618, inhibits the degradation of phosphorylated Ampk alpha by targeting the protein Fbxo48, thereby enhancing Ampk biological activity and promoting mitochondrial fission, autophagy, and improved insulin sensitivity in obese mice. This study reveals a novel pathway for regulating Ampk activity.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Pei Wang, Shangcheng Xu, Jiqian Xu, Yanguo Xin, Yan Lu, Huiliang Zhang, Bo Zhou, Haodong Xu, Shey-Shing Sheu, Rong Tian, Wang Wang
Summary: This study reveals that chronic stress can upregulate the expression of mitochondrial calcium uniporter (MCU), preserving calcium homeostasis and cardiomyocyte viability to counteract stress-induced pathological cardiac remodeling.
Letter
Cardiac & Cardiovascular Systems
Yunosuke Matsuura, Masami Shimizu-Albergine, Shelley Barnhart, Farah Kramer, Cheng-Chieh Hsu, Vishal Kothari, Jingjing Tang, Sina A. Gharib, Jenny E. Kanter, E. Dale Abel, Rong Tian, Baohai Shao, Karin E. Bornfeldt
CIRCULATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jason W. Miklas, Shiri Levy, Peter Hofsteen, Diego Ic Mex, Elisa Clark, Jeanot Muster, Aaron M. Robitaille, Gargi Sivaram, Lauren Abell, Jamie M. Goodson, Inez Pranoto, Anup Madan, Michael T. Chin, Rong Tian, Charles E. Murry, Randall T. Moon, Yuliang Wang, Hannele Ruohola-Baker
Summary: The ability of zebrafish and neonatal mouse myocardial cells to regenerate the heart through dedifferentiation and proliferation is explored. The study demonstrates a unique metabolic state and mitochondrial changes that contribute to this regenerative capability.
Article
Engineering, Multidisciplinary
Jinwei Ma, Qinglin Duan, Rong Tian
Summary: This paper presents a nonlinear generalized finite element method (GFEM) for large deformation analysis of elastic and elastoplastic solids in three dimensions. By eliminating the extra degrees of freedom, the developed method is more convenient to implement than the standard GFEM and does not suffer from singular system matrix. Numerical results demonstrate that the proposed nonlinear GFEM is remarkably more accurate and stable than the traditional finite element method in modeling three-dimensional large elastoplastic deformations.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2022)
Article
Engineering, Mechanical
Dongyang Chu, Zhijie Li, Kaili Yao, Yigang Wang, Rong Tian, Zhuo Zhuang, Zhanli Liu
Summary: This paper investigates the strengthening mechanism and thickness effect of polyurea coating under fragment simulating projectiles impact. Experimental and numerical analysis shows that the impact-induced stiffening and strengthening of polyurea and the regulation of impact wave play a key role in improving the ballistic resistance of the steel plate. Increasing the coating thickness has limited benefits for improving the ballistic resistance, and can even reduce the energy dissipation during penetration.
INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Dennis D. Wang, Sophia E. Airhart, Bo Zhou, Laura M. Shireman, Siyi Jiang, Carolina Melendez Rodriguez, James N. Kirkpatrick, Danny D. Shen, Rong Tian, Kevin D. O'Brien
Summary: Mitochondrial dysfunction in heart failure is associated with changes in NAD(+) and NADH levels. Raising NAD(+) levels using nicotinamide riboside (NR) may be a promising treatment for heart failure. In a trial involving 30 clinically stable heart failure patients, NR at a dose of 1,000 mg twice daily was found to be safe and well tolerated, and it approximately doubled whole blood NADthorn levels. The increase in NAD(+) in response to NR correlated with improved peripheral blood mononuclear cell respiration and reduced NLRP3 expression.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Biophysics
Minghan Li, Shanchuan Chen, Yunjiao Wang, Shaoxia Zhang, Dandan Song, Rong Tian, Jia Geng, Liang Wang
Summary: In this study, a nanopore platform was fabricated to monitor intercellular protein transport and detect the activity of anthrax lethal factor (aLF) at a single molecule level. The aLF activity was successfully inhibited using screening approaches of protein-metal ion acquisition and other condition controlment. Ca2+, Mg2+, Mn2+, Ni2+ in collaboration with Zn2+ were found to promote aLF activity, while Cd2+, Co2+, Cu2+ showed inhibitory effects. The results also revealed that the speed of aLF endopeptidase activity with different ions functions as the nanopore signal frequency in a linear manner. In addition, the strength of the proton or hydroxide, as well as adapted temperature and gamma-ray, played integral roles in inhibiting aLF activity.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Cardiac & Cardiovascular Systems
Yuan-Yuan Cheng, Zachery Gregorich, Ray P. Prajnamitra, David J. Lundy, Ting-Yun Ma, Yu-Hsuan Huang, Yi-Chan Lee, Shu-Chian Ruan, Jen-Hao Lin, Po-Ju Lin, Chiung-Wen Kuo, Peilin Chen, Yu-Ting Yan, Rong Tian, Timothy J. Kamp, Patrick C. H. Hsieh
Summary: This study reveals that induction of Yamanaka factors in adult mice can lead to dedifferentiation and proliferation of cardiomyocytes, allowing cardiac regeneration. Upregulation of ketogenesis is found to be central to this process. Similar phenomenon is observed after myocardial infarction and in the border zone tissue.
Article
Engineering, Multidisciplinary
Guizhong Xiao, Longfei Wen, Rong Tian, Dingguo Zhang
Summary: An improved XFEM (IXFEM) method is proposed for three-dimensional non-planar crack propagation under impact loadings. The method combines IXFEM and the B-spline ruled surface method (BRSM) to overcome the issues of standard XFEM in dynamic crack propagation. The proposed method employs an extra-DOF free PU approximation and tip singularity enrichment to ensure high accuracy. The BRSM is used to model the geometry of 3D dynamic crack propagation, and the interaction integral for 2D dynamic stress intensity factor (SIF) evaluation is extended to 3D. The efficiency of the proposed approach is demonstrated through numerical tests.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Logan Bailey, Isabella Reichardt, Dessiree Ortac, Tomoya Sakamoto, Daniel Kelly, Michael Regnier, Rong Tian, Jennifer Davis
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ketaki N. Mhatre, Jason D. Murray, Galina Flint, Timothy S. McMillen, Gerhard Weber, Majid Shakeri, An-Yue Tu, Sonette Steczina, Robert Weiss, David J. Marcinek, Charles E. Murry, Daniel Raftery, Rong Tian, Farid Moussavi-Harami, Michael Regnier
Summary: The hallmark features of systolic heart failure involve reduced contractility and impaired metabolic flexibility of the myocardium. Elevated dATP levels in cardiomyocytes (CMs) through overexpression of ribonucleotide reductase (RNR) enzyme can substantially improve contractility. However, the effect of dATP elevation on cardiac metabolism remains unknown.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Rong Tian, Michael Regnier
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Chemistry, Analytical
Wenhao Ma, Wanyi Xie, Rong Tian, Xiaoqing Zeng, Liyuan Liang, Changjun Hou, Danqun Huo, Deqiang Wang
Summary: Since the outbreak of COVID-19, rapid and effective detection methods have been a focus of research. This study utilized aptamer-functionalized nanopipettes with unique ion current rectification properties to achieve rapid and highly sensitive detection of trace viral protein, reducing the cost of detection. The sensor platform exhibited a wide dynamic working range and a low detection limit, showing great potential as a tool for rapid detection of SARS-CoV-2.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Medicine, Research & Experimental
Shanshan Cai, Mingyue Zhao, Bo Zhou, Akira Yoshii, Darrian Bugg, Outi Villet, Anita Sahu, Gregory S. Olson, Jennifer Davis, Rong Tian
Summary: Innate immune cells have a crucial role in tissue injury and repair after acute myocardial infarction (MI). This study uncovered the mechanistic link between macrophage metabolism and phenotype by investigating the myeloid-specific deletion of mitochondrial complex I protein, Ndufs4. The results demonstrated that impaired mitochondrial function in macrophages resulted in an exaggerated inflammatory response, poor scar formation, and worsened cardiac function after MI.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Jing Wu, Komudi Singh, Amy Lin, Allison M. Meadows, Kaiyuan Wu, Vivian Shing, Maximilian Bley, Shahin Hassanzadeh, Rebecca D. Huffstutler, Mark S. Schmidt, Luz P. Blanco, Rong Tian, Charles Brenner, Mehdi Pirooznia, Mariana J. Kaplan, Michael N. Sack
Summary: This study reveals that nicotinamide riboside (NR) can suppress autophagy and attenuate type I interferon (IFN-beta) release in myeloid cells, exerting anti-inflammatory effects. The mechanism of action involves NR's dependency on NAD(+) and its modulation of inosine signaling. These findings suggest NR as a potential adjunct for the management of systemic lupus erythematosus (SLE).
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
