Synthetic surfactants with SP-B and SP-C analogues to enable worldwide treatment of neonatal respiratory distress syndrome and other lung diseases

A spidroin-derived solubility tag enables controlled aggregation of a designed amyloid protein

(2018) Médoune Sarr et al.   FEBS Journal

BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells

(2018) Marie E. Oskarsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effective in vivo treatment of acute lung injury with helical, amphipathic peptoid mimics of pulmonary surfactant proteins

(2018) Ann M. Czyzewski et al.   Scientific Reports

Cerebral and lung effects of a new generation synthetic surfactant with SP-B and SP-C analogs in preterm lambs

(2017) Carmen Rey-Santano et al.   PEDIATRIC PULMONOLOGY

Respiratory Distress in Neonates

(2017) Mark C. Liszewski et al.   RADIOLOGIC CLINICS OF NORTH AMERICA

Interstitial lung disease in newborns

(2017) Lawrence M. Nogee   Seminars in Fetal & Neonatal Medicine

Efficient protein production inspired by how spiders make silk

(2017) Nina Kronqvist et al.   Nature Communications

Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state

(2017) Gefei Chen et al.   Nature Communications

Transthyretin and BRICHOS: The Paradox of Amyloidogenic Proteins with Anti-Amyloidogenic Activity for Aβ in the Central Nervous System

(2017) Joel N. Buxbaum et al.   Frontiers in Neuroscience

Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines

(2016) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Lung surfactant: Function and composition in the context of development and respiratory physiology

(2016) Wolfgang Bernhard   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Dementia-related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits A 42 toxicity in Drosophila

(2016) H. Poska et al.   BIOCHEMICAL JOURNAL

Combined effect of synthetic protein, Mini-B, and cholesterol on a model lung surfactant mixture at the air–water interface

(2016) Aishik Chakraborty et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A small key unlocks a heavy door: The essential function of the small hydrophobic proteins SP-B and SP-C to trigger adsorption of pulmonary surfactant lamellar bodies

(2016) Nina Hobi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lung surfactant metabolism: early in life, early in disease and target in cell therapy

(2016) Elena Lopez-Rodriguez et al.   CELL AND TISSUE RESEARCH

Peptide-based synthetic pulmonary surfactant for the treatment of respiratory distress disorders

(2016) Otonye Braide-Moncoeur et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The new generation synthetic reconstituted surfactant CHF5633 suppresses LPS-induced cytokine responses in human neonatal monocytes

(2016) Kirsten Glaser et al.   CYTOKINE

Anti-inflammatory effects of the new generation synthetic surfactant CHF5633 on Ureaplasma-induced cytokine responses in human monocytes

(2016) Kirsten Glaser et al.   Expert Review of Anti-Infective Therapy

Crystal Structure of a Complex of Surfactant Protein D (SP-D) and Haemophilus influenzae Lipopolysaccharide Reveals Shielding of Core Structures in SP-D-Resistant Strains

(2016) Howard W. Clark et al.   INFECTION AND IMMUNITY

Phospholipid Composition in Synthetic Surfactants Is Important for Tidal Volumes and Alveolar Stability in Surfactant-Treated Preterm Newborn Rabbits

(2016) Andrea Calkovska et al.   Neonatology

In vitro and in vivo comparison between poractant alfa and the new generation synthetic surfactant CHF5633

(2016) Francesca Ricci et al.   PEDIATRIC RESEARCH

Evolution of surfactant therapy for respiratory distress syndrome: past, present and future

(2016) Smeeta Sardesai et al.   PEDIATRIC RESEARCH

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

(2016) Paolo Arosio et al.   Nature Communications

Activity and biophysical inhibition resistance of a novel synthetic lung surfactant containing Super-Mini-B DATK peptide

(2016) Robert H. Notter et al.   PeerJ

Synthetic lung surfactants containing SP-B and SP-C peptides plus novel phospholipase-resistant lipids or glycerophospholipids

(2016) Robert H. Notter et al.   PeerJ

Effects of the New Generation Synthetic Reconstituted Surfactant CHF5633 on Pro- and Anti-Inflammatory Cytokine Expression in Native and LPS-Stimulated Adult CD14+ Monocytes

(2016) Kirsten Glaser et al.   PLoS One

Impact of the New Generation Reconstituted Surfactant CHF5633 on Human CD4+ Lymphocytes

(2016) Markus Fehrholz et al.   PLoS One

Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease

(2015) Surafel Mulugeta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Outcomes for Extremely Premature Infants

(2015) Hannah C. Glass et al.   ANESTHESIA AND ANALGESIA

Diseases of Pulmonary Surfactant Homeostasis

(2015) Jeffrey A. Whitsett et al.   Annual Review of Pathology-Mechanisms of Disease

Mechanistic Insights into the Lipid Interaction of an Ancient Saposin-like Protein

(2015) Matthias Michalek et al.   BIOCHEMISTRY

Palmitoylation as a key factor to modulate SP-C–lipid interactions in lung surfactant membrane multilayers

(2015) Nuria Roldan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Hydrophobic Surfactant Proteins Strongly Induce Negative Curvature

(2015) Mariya Chavarha et al.   BIOPHYSICAL JOURNAL

Diversified Structural Basis of a Conserved Molecular Mechanism for pH-Dependent Dimerization in Spider Silk N-Terminal Domains

(2015) Martins Otikovs et al.   CHEMBIOCHEM

Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films

(2015) Elisa Parra et al.   CHEMISTRY AND PHYSICS OF LIPIDS

A model for the structure and mechanism of action of pulmonary surfactant protein B

(2015) Bárbara Olmeda et al.   FASEB JOURNAL

Folding and Intramembraneous BRICHOS Binding of the Prosurfactant Protein C Transmembrane Segment

(2015) Alejandra Sáenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural Anti-Infective Pulmonary Proteins: In Vivo Cooperative Action of Surfactant Protein SP-A and the Lung Antimicrobial Peptide SP-BN

(2015) Juan Manuel Coya et al.   JOURNAL OF IMMUNOLOGY

Toward spinning artificial spider silk

(2015) Anna Rising et al.   Nature Chemical Biology

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Unique Story in Neonatal Research: The Development of a Porcine Surfactant

(2015) Tore Curstedt et al.   Neonatology

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The chaperone domain BRICHOS prevents CNS toxicity of amyloid-  peptide in Drosophila melanogaster

(2014) E. Hermansson et al.   Disease Models & Mechanisms

Macrophage Dysfunction and Susceptibility to Pulmonary Pseudomonas aeruginosa Infection in Surfactant Protein C-Deficient Mice

(2014) S. W. Glasser et al.   JOURNAL OF IMMUNOLOGY

Protein modeling and molecular dynamics simulation of the two novel surfactant proteins SP-G and SP-H

(2014) Felix Rausch et al.   JOURNAL OF MOLECULAR MODELING

Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation

(2014) Nina Kronqvist et al.   Nature Communications

Surfactant protein C peptides with salt-bridges (“ion-locks”) promote high surfactant activities by mimicking theα-helix and membrane topography of the native protein

(2014) Frans J. Walther et al.   PeerJ

Synthetic surfactant containing SP-B and SP-C mimics is superior to single-peptide formulations in rabbits with chemical acute lung injury

(2014) Frans J. Walther et al.   PeerJ

The BRICHOS Domain, Amyloid Fibril Formation, and Their Relationship

(2013) Stefan D. Knight et al.   BIOCHEMISTRY

Preterm birth time trends in Europe: a study of 19 countries

(2013) J Zeitlin et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Poractant alfa versus beractant for respiratory distress syndrome in preterm infants: A retrospective cohort study

(2013) Saritha Paul et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Effects of Natural versus Synthetic Surfactant with SP-B and SP-C Analogs in a Porcine Model of Meconium Aspiration Syndrome

(2013) Bodil Salvesen et al.   Neonatology

Annual Summary of Vital Statistics: 2010-2011

(2013) B. E. Hamilton et al.   PEDIATRICS

Role of the N-Terminal Seven Residues of Surfactant Protein B (SP-B)

(2013) Mahzad Sharifahmadian et al.   PLoS One

Structural Architecture and Functional Evolution of Wnts

(2012) J. Fernando Bazan et al.   DEVELOPMENTAL CELL

Effects of the lung surfactant protein B construct Mini-B on lipid bilayer order and topography

(2012) Dharamaraju Palleboina et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Structure–function correlations of pulmonary surfactant protein SP-B and the saposin-like family of proteins

(2012) Bárbara Olmeda et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Immunomodulatory properties of surfactant preparations

(2012) Iliana Bersani et al.   Expert Review of Anti-Infective Therapy

BRICHOS Domains Efficiently Delay Fibrillation of Amyloid β-Peptide

(2012) Hanna Willander et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

pH‐Dependent Dimerization of Spider Silk N-Terminal Domain Requires Relocation of a Wedged Tryptophan Side Chain

(2012) Kristaps Jaudzems et al.   JOURNAL OF MOLECULAR BIOLOGY

Lucinactant attenuates pulmonary inflammatory response, preserves lung structure and improves physiologic outcomes in a preterm lamb model of RDS

(2012) Marla R. Wolfson et al.   PEDIATRIC RESEARCH

SP-B and SP-C Containing New Synthetic Surfactant for Treatment of Extremely Immature Lamb Lung

(2012) Atsuyasu Sato et al.   PLoS One

New Surfactant with SP-B and C Analogs Gives Survival Benefit after Inactivation in Preterm Lambs

(2012) Matthias Seehase et al.   PLoS One

High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C

(2012) H. Willander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human  -Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets

(2012) H. Chu et al.   SCIENCE

A combined action of pulmonary surfactant proteins SP-B and SP-C modulates permeability and dynamics of phospholipid membranes

(2011) Elisa Parra et al.   BIOCHEMICAL JOURNAL

Alterations of the C-terminal end do not affect in vitro or in vivo activity of surfactant protein C analogs

(2011) Andreas Almlén et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Biomimetic N-Terminal Alkylation of Peptoid Analogues of Surfactant Protein C

(2011) Nathan J. Brown et al.   BIOPHYSICAL JOURNAL

APP physiological and pathophysiological functions: insights from animal models

(2011) Qinxi Guo et al.   CELL RESEARCH

Structure and Mechanism of the Saposin-like Domain of a Plant Aspartic Protease

(2011) Brian C. Bryksa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Conformational preferences of non-polar amino acid residues: An additional factor in amyloid formation

(2010) Jan Johansson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crystallographic Complexes of Surfactant Protein A and Carbohydrates Reveal Ligand-induced Conformational Change

(2010) Feifei Shang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Self-assembly of spider silk proteins is controlled by a pH-sensitive relay

(2010) Glareh Askarieh et al.   NATURE

Synthetic Surfactant Based on Analogues of SP-B and SP-C Is Superior to Single-Peptide Surfactants in Ventilated Premature Rabbits

(2010) Andreas Almlén et al.   Neonatology

Different Effects of Surfactant Proteins B and C – Implications for Development of Synthetic Surfactants

(2010) Tore Curstedt et al.   Neonatology

Prophylactic Intratracheal Polymyxin B/Surfactant Prevents Bacterial Growth in Neonatal Escherichia coli Pneumonia of Rabbits

(2010) Guido Stichtenoth et al.   PEDIATRIC RESEARCH

Critical Structural and Functional Roles for the N-Terminal Insertion Sequence in Surfactant Protein B Analogs

(2010) Frans J. Walther et al.   PLoS One

Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection

(2009) Stephan W. Glasser et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Exogenous Natural Surfactant for Treatment of Acute Lung Injury and the Acute Respiratory Distress Syndrome

(2009) Jozef Kesecioglu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The extracellular domain of Bri2 (ITM2B) binds the ABri peptide (1–23) and amyloid β-peptide (Aβ1–40): Implications for Bri2 effects on processing of amyloid precursor protein and Aβ aggregation

(2009) Siwei Peng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-Amyloid Activity of the C-Terminal Domain of proSP-C against Amyloid β-Peptide and Medin†

(2009) Charlotte Nerelius et al.   BIOCHEMISTRY

Caenopore-5: The three-dimensional structure of an antimicrobial protein from Caenorhabditis elegans

(2009) Justyna Mysliwy et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Surfactant Protein B Propeptide Contains a Saposin-Like Protein Domain with Antimicrobial Activity at Low pH

(2009) L. Yang et al.   JOURNAL OF IMMUNOLOGY

Preventing Amyloid Formation by Catching Unfolded Transmembrane Segments

(2009) H. Johansson et al.   JOURNAL OF MOLECULAR BIOLOGY

An overview of pulmonary surfactant in the neonate: Genetics, metabolism, and the role of surfactant in health and disease

(2009) Paul O. Nkadi et al.   MOLECULAR GENETICS AND METABOLISM

Genetic Disorders of Surfactant Dysfunction

(2009) Susan E. Wert et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

The Brichos domain of prosurfactant protein C can hold and fold a transmembrane segment

(2009) Hanna Johansson et al.   PROTEIN SCIENCE

Biomimicry of Surfactant Protein C

(2008) Nathan J. Brown et al.   ACCOUNTS OF CHEMICAL RESEARCH

Mutations linked to interstitial lung disease can abrogate anti-amyloid function of prosurfactant protein C

(2008) Charlotte Nerelius et al.   BIOCHEMICAL JOURNAL

Effects of Hydrophobic Helix Length and Side Chain Chemistry on Biomimicry in Peptoid Analogues of SP-C†

(2008) Nathan J. Brown et al.   BIOCHEMISTRY

Effect of acylation on the interaction of the N-Terminal segment of pulmonary surfactant protein SP-C with phospholipid membranes

(2008) I. Plasencia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Surfactant Peptide KL4 Sequence Is Inserted with a Transmembrane Orientation into the Endoplasmic Reticulum Membrane

(2008) Luis Martínez-Gil et al.   BIOPHYSICAL JOURNAL

Surfactant proteins B and C are both necessary for alveolar stability at end expiration in premature rabbits with respiratory distress syndrome

(2008) Andreas Almlén et al.   JOURNAL OF APPLIED PHYSIOLOGY

Pepsinogen C Proteolytic Processing of Surfactant Protein B

(2008) Kristin D. Gerson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of Human Saposins C and D: Implications for Lipid Recognition and Membrane Interactions

(2008) Maxim Rossmann et al.   STRUCTURE