Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer’s Disease and Brain Insulin Resistance, and Its Relation to Cancer
出版年份 2018 全文链接
标题
Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer’s Disease and Brain Insulin Resistance, and Its Relation to Cancer
作者
关键词
-
出版物
JOURNAL OF ALZHEIMERS DISEASE
Volume 67, Issue 1, Pages 1-11
出版商
IOS Press
发表日期
2018-11-17
DOI
10.3233/jad-180874
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Oncogene-induced senescence: a double edged sword in cancer
- (2018) Xue-ling Liu et al. ACTA PHARMACOLOGICA SINICA
- N-methyl-D-aspartate receptor–mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer's disease
- (2018) Erin J. Kodis et al. Alzheimers & Dementia
- CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought
- (2018) Mary E. Klein et al. CANCER CELL
- The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease
- (2018) Andre F Batista et al. JOURNAL OF PATHOLOGY
- Targeting the PI3K pathway in cancer: are we making headway?
- (2018) Filip Janku et al. Nature Reviews Clinical Oncology
- Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
- (2018) Steven E. Arnold et al. Nature Reviews Neurology
- Reduced brain insulin signaling: A seminal process in Alzheimer's disease pathogenesis
- (2018) George S. Bloom et al. NEUROPHARMACOLOGY
- Cell cycle heterogeneity directs the timing of neural stem cell activation from quiescence
- (2018) L. Otsuki et al. SCIENCE
- A novel lysosome‐to‐mitochondria signaling pathway disrupted by amyloid‐β oligomers
- (2018) Andrés Norambuena et al. EMBO JOURNAL
- The Rotterdam Study: 2018 update on objectives, design and main results
- (2017) M. Arfan Ikram et al. EUROPEAN JOURNAL OF EPIDEMIOLOGY
- Natural and synthetic bioactive inhibitors of glycogen synthase kinase
- (2017) Imran Khan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a
- (2017) Matteo Spinelli et al. Nature Communications
- Alzheimer's Disease and the Amyloid-β Peptide
- (2017) M. Paul Murphy et al. JOURNAL OF ALZHEIMERS DISEASE
- Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes
- (2016) Kei-ichi Ozaki et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Targeting Ras Activity Prevented Amyloid Beta-Induced Aberrant Neuronal Cell Cycle Re-Entry and Death
- (2016) M. Murat Koseoglu et al. Current Alzheimer Research
- Do Cancer Drugs Counteract Neurodegeneration? Repurposing for Alzheimer’s Disease
- (2016) Fiammetta Monacelli et al. JOURNAL OF ALZHEIMERS DISEASE
- The Rationale for Insulin Therapy in Alzheimer’s Disease
- (2016) Samo Ribarič MOLECULES
- Spatial colocalization and functional link of purinosomes with mitochondria
- (2016) J. B. French et al. SCIENCE
- mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
- (2016) I. Ben-Sahra et al. SCIENCE
- Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1–42 induced neurotoxicity and memory impairment
- (2016) Paula Maria Quaglio Bellozi et al. Scientific Reports
- Tau: The Center of a Signaling Nexus in Alzheimer's Disease
- (2016) Shahzad S. Khan et al. Frontiers in Neuroscience
- Drug repositioning and repurposing: terminology and definitions in literature
- (2015) Joris Langedijk et al. DRUG DISCOVERY TODAY
- JNK pathway signaling: a novel and smarter therapeutic targets for various biological diseases
- (2015) Ankit Kumar et al. Future Medicinal Chemistry
- Amyloid-β Receptors: The Good, the Bad, and the Prion Protein
- (2015) Heledd H. Jarosz-Griffiths et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Stamping out RAF and MEK1/2 to inhibit the ERK1/2 pathway: an emerging threat to anticancer therapy
- (2015) R Mandal et al. ONCOGENE
- Tyrosine Kinase Inhibitors and Diabetes: A Novel Treatment Paradigm?
- (2015) Athanasios Fountas et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer’s disease
- (2015) Haakon B Nygaard et al. Alzheimers Research & Therapy
- What lessons can be learned from failed Alzheimer’s disease trials?
- (2015) Jeremy Toyn Expert Review of Clinical Pharmacology
- How does brain insulin resistance develop in Alzheimer's disease?
- (2014) Fernanda G. De Felice et al. Alzheimers & Dementia
- Lessons from a Failed γ-Secretase Alzheimer Trial
- (2014) Bart De Strooper CELL
- Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer’s disease
- (2014) Tae-In Kam et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Insulin Regulates Brain Function, but How Does It Get There?
- (2014) S. M. Gray et al. DIABETES
- Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease
- (2014) M. Yarchoan et al. DIABETES
- Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review
- (2014) Suzanne M. de la Monte EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Contribution of Alzheimer disease to mortality in the United States
- (2014) B. D. James et al. NEUROLOGY
- Potential repurposing of oncology drugs for the treatment of Alzheimer's disease
- (2013) Wataru Araki BMC Medicine
- mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
- (2013) Masahiro Morita et al. Cell Metabolism
- Amyloid- signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease
- (2013) M. E. Seward et al. JOURNAL OF CELL SCIENCE
- Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events
- (2013) Kiran Bhaskar et al. NEUROBIOLOGY OF DISEASE
- A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
- (2013) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy of Cyclin Dependent Kinase 4 Inhibitors as Potent Neuroprotective Agents against Insults Relevant to Alzheimer’s Disease
- (2013) Priyankar Sanphui et al. PLoS One
- Cancer: NF-κB regulates energy metabolism
- (2012) Marta Moretti et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death
- (2012) K.-H. Chang et al. JOURNAL OF CELL SCIENCE
- An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
- (2012) Theresa R. Bomfim et al. JOURNAL OF CLINICAL INVESTIGATION
- Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events
- (2012) Xiaohong Xu et al. Stem Cell Research
- The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation
- (2012) Laura Tornatore et al. TRENDS IN CELL BIOLOGY
- Targeting the Extracellular Signal-Regulated Kinase Pathway in Cancer Therapy
- (2011) Michiaki Kohno et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- A Phase II Trial of Salirasib in Patients with Lung Adenocarcinomas with KRAS Mutations
- (2011) Gregory J. Riely et al. Journal of Thoracic Oncology
- Selective Cell Death of Hyperploid Neurons in Alzheimer’s Disease
- (2010) Thomas Arendt et al. AMERICAN JOURNAL OF PATHOLOGY
- Pathological implications of cell cycle re-entry in Alzheimer disease
- (2010) David J. Bonda et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Amyloid oligomers: formation and toxicity of Aβ oligomers
- (2010) Masafumi Sakono et al. FEBS Journal
- Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?
- (2010) I. Ben Sahra et al. MOLECULAR CANCER THERAPEUTICS
- Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
- (2010) Patricia Spilman et al. PLoS One
- Insulin signaling meets mitochondria in metabolism
- (2010) Zhiyong Cheng et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- The Neuronal Expression of MYC Causes a Neurodegenerative Phenotype in a Novel Transgenic Mouse
- (2009) Hyoung-gon Lee et al. AMERICAN JOURNAL OF PATHOLOGY
- The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events
- (2009) Kiran Bhaskar et al. Molecular Neurodegeneration
- Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid
- (2008) Carme Pelegrí et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
- A Oligomers Induce Neuronal Cell Cycle Events in Alzheimer's Disease
- (2008) N. H. Varvel et al. JOURNAL OF NEUROSCIENCE
- Ras oncogenes: split personalities
- (2008) Antoine E. Karnoub et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons
- (2008) W. S. Liang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amyloid beta oligomers induce impairment of neuronal insulin receptors
- (2007) Wei-Qin Zhao et al. FASEB JOURNAL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation