Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients

(2016) Eric R. Siemers et al.   Alzheimers & Dementia

Antibody against Small Aggregated Peptide Specifically Recognizes Toxic Aβ-42 Oligomers in Alzheimer’s Disease

(2015) Riddhi U. Bodani et al.   ACS Chemical Neuroscience

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay

(2015) Emmanuel Risse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models

(2015) Mikhail A. Kostylev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

(2015) Zhen Zhao et al.   NATURE NEUROSCIENCE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

(2015) Takayuki Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

(2015) Peng Liu et al.   Cell Reports

Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity

(2015) Wen-Jie Du et al.   Scientific Reports

The Binding of Apolipoprotein E to Oligomers and Fibrils of Amyloid-β Alters the Kinetics of Amyloid Aggregation

(2014) Kanchan Garai et al.   BIOCHEMISTRY

High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer’s disease

(2014) Frank Dohler et al.   BRAIN

Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis

(2014) Deborah Doens et al.   Journal of Neuroinflammation

Apolipoprotein E: Structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases

(2014) Yadong Huang et al.   NEUROBIOLOGY OF DISEASE

EphA4 Activation of c-Abl Mediates Synaptic Loss and LTP Blockade Caused by Amyloid-β Oligomers

(2014) Lina M. Vargas et al.   PLoS One

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

(2014) Nicholas J. Izzo et al.   PLoS One

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits

(2014) Nicholas J. Izzo et al.   PLoS One

Toward a unified therapeutics approach targeting putative amyloid-  oligomer receptors

(2014) C. R. Overk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease

(2014) Amy K. Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fyn kinase inhibition as a novel therapy for Alzheimer’s disease

(2014) Haakon B Nygaard et al.   Alzheimers Research & Therapy

Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer’s disease immunotherapeutics

(2014) William F Goure et al.   Alzheimers Research & Therapy

Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer’s disease

(2014) Natalia N. Nalivaeva et al.   Frontiers in Aging Neuroscience

A Lipoprotein Receptor Cluster IV Mutant Preferentially Binds Amyloid-β and Regulates Its Clearance from the Mouse Brain

(2013) Abhay P. Sagare et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion Protein-mediated Toxicity of Amyloid-β Oligomers Requires Lipid Rafts and the Transmembrane LRP1

(2013) Jo V. Rushworth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer’s disease

(2013) Tae-In Kam et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuronal Clearance of Amyloid-  by Endocytic Receptor LRP1

(2013) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

Promiscuous Alzheimer's Amyloid: Yet Another Partner

(2013) I. Benilova et al.   SCIENCE

Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

(2013) T. Kim et al.   SCIENCE

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity

(2013) Andrew J. Nicoll et al.   Nature Communications

Amyloid-β Oligomers are Sequestered by both Intracellular and Extracellular Chaperones

(2012) Priyanka Narayan et al.   BIOCHEMISTRY

Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes

(2012) Jacob M. Basak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β (Aβ) Peptide Directly Activates Amylin-3 Receptor Subtype by Triggering Multiple Intracellular Signaling Pathways

(2012) Wen Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Prion Protein Participates in Amyloid-β Transcytosis across the Blood—Brain Barrier

(2012) Thorsten Pflanzner et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid- 

(2012) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Soluble A  Promotes Wild-Type Tau Pathology In Vivo

(2012) M. A. Chabrier et al.   JOURNAL OF NEUROSCIENCE

The Complex PrPc-Fyn Couples Human Oligomeric A  with Pathological Tau Changes in Alzheimer's Disease

(2012) M. Larson et al.   JOURNAL OF NEUROSCIENCE

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway

(2012) R Killick et al.   MOLECULAR PSYCHIATRY

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood A  clearance in a mouse model of  -amyloidosis

(2012) J. M. Castellano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Out-of-register  -sheets suggest a pathway to toxic amyloid aggregates

(2012) C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease

(2011) H. Rheinallt Parri et al.   BIOCHEMICAL PHARMACOLOGY

The Synaptic Protein Neuroligin-1 Interacts with the Amyloid β-Peptide. Is There a Role in Alzheimer’s Disease?

(2011) Margarita C. Dinamarca et al.   BIOCHEMISTRY

Single-channel Ca2+imaging implicates Aβ1–42 amyloid pores in Alzheimer’s disease pathology

(2011) Angelo Demuro et al.   JOURNAL OF CELL BIOLOGY

Alzheimer's Disease Brain-Derived Amyloid- -Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein

(2011) A. E. Barry et al.   JOURNAL OF NEUROSCIENCE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-  Uptake

(2011) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices

(2011) Gerhard Rammes et al.   NEUROPHARMACOLOGY

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

(2011) Darragh B. Freir et al.   Nature Communications

Signalosomes in the brain: relevance in the development of certain neuropathologies such as Alzheimer’s disease

(2011) Raquel Marin   Frontiers in Physiology

Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an alzheimer's disease model mouse

(2010) Erika Chung et al.   BMC NEUROSCIENCE

β-Amyloid activates presynaptic α7 nicotinic acetylcholine receptors reconstituted into a model nerve cell system: involvement of lipid rafts

(2010) Ghous M. Khan et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Binding of amyloid β peptide to β2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

(2010) Dayong Wang et al.   FASEB JOURNAL

Cellular roles of the prion protein in association with reggie/flotillin microdomains

(2010) Gonzalo et al.   Frontiers in Bioscience-Landmark

Resveratrol Selectively Remodels Soluble Oligomers and Fibrils of Amyloid Aβ into Off-pathway Conformers

(2010) Ali Reza A. Ladiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between Human Prion Protein and Amyloid-β (Aβ) Oligomers

(2010) Shugui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells

(2010) Lars-Ove Brandenburg et al.   JOURNAL OF NEUROCHEMISTRY

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

Microglial Receptor for Advanced Glycation End Product-Dependent Signal Pathway Drives  -Amyloid-Induced Synaptic Depression and Long-Term Depression Impairment in Entorhinal Cortex

(2010) N. Origlia et al.   JOURNAL OF NEUROSCIENCE

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

(2010) Moustapha Cissé et al.   NATURE

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid β-Protein (Aβ) Assembly from Alzheimer Disease Brains

(2009) Akihiko Noguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

(2009) Wei-Qin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

(2009) Jennifer L. Tomic et al.   NEUROBIOLOGY OF DISEASE

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease

(2009) M. Britschgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RAGE-mediated signaling contributes to intraneuronal transport of amyloid-  and neuronal dysfunction

(2009) K. Takuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glypican-1 Mediates Both Prion Protein Lipid Raft Association and Disease Isoform Formation

(2009) David R. Taylor et al.   PLoS Pathogens

In situAbetapores in AD brain are cylindrical assembly of Abetaprotofilaments

(2008) Sadayuki Inoue   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling

(2008) Margaret H. Magdesian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid   Oligomers (A 1-42 Globulomer) Suppress Spontaneous Synaptic Activity by Inhibition of P/Q-Type Calcium Currents

(2008) V. Nimmrich et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Physiology of the Prion Protein

(2008) Rafael Linden et al.   PHYSIOLOGICAL REVIEWS