JNK pathway signaling: a novel and smarter therapeutic targets for various biological diseases

Novel roles for JNK1 in metabolism

(2016) Bengt F. Belgardt et al.   Aging-US

Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): Optimization for JNK potency and physicochemical properties

(2013) Leyi Gong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors

(2013) Bei Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Asthmatic airway smooth muscle CXCL10 production: mitogen-activated protein kinase JNK involvement

(2012) Yazan A. Alrashdan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis

(2012) Nicole Reich et al.   ANNALS OF THE RHEUMATIC DISEASES

Discovery of a novel series of 4-quinolone JNK inhibitors

(2012) Leyi Gong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-benzotriazole lead

(2012) Wylie S. Palmer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Potent and Selective Covalent Inhibitors of JNK

(2012) Tinghu Zhang et al.   CHEMISTRY & BIOLOGY

JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides

(2012) Sung Ok Yoon et al.   NEURON

JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis

(2011) Monica Guma et al.   ARTHRITIS AND RHEUMATISM

Design, synthesis, and structure–activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase

(2011) Surya K. De et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement

(2011) R. Jeffrey Neitz et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor

(2011) Simeon Bowers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) Inhibitors

(2011) Yuanjun He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration

(2011) Simeon Bowers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR of 2-Phenoxypyridines as novel c-Jun N-terminal kinase inhibitors

(2011) Xinyi Song et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury

(2011) Véronique Plantevin Krenitsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

(2011) Véronique Plantevin Krenitsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of JNK in Mammary Gland Development and Breast Cancer

(2011) C. Cellurale et al.   CANCER RESEARCH

Levodopa Activates Apoptosis Signaling Kinase 1 (ASK1) and Promotes Apoptosis in a Neuronal Model: Implications for the Treatment of Parkinson's Disease

(2011) Elizabeth A. Sabens Liedhegner et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK

(2010) Roy K. Hom et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors

(2010) Romain Noël et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The c-Jun N-terminal kinase inhibitor SP600125 is neuroprotective in amygdala kindled rats

(2010) Xu Chen et al.   BRAIN RESEARCH

Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers

(2010) Chiara Ferrandi et al.   Multiple Sclerosis Journal

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease

(2010) Steven P. Braithwaite et al.   NEUROBIOLOGY OF DISEASE

cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance

(2010) Guadalupe Sabio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors

(2009) Surya K. De et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors

(2009) Surya K. De et al.   BIOORGANIC & MEDICINAL CHEMISTRY

1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3

(2009) John A. Christopher et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors

(2009) Youseung Shin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38

(2009) Ted Kamenecka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and Structure−Activity Relationship of Substrate Competitive, Selective, and in Vivo Active Triazole and Thiadiazole Inhibitors of the c-Jun N-Terminal Kinase

(2009) Surya K. De et al.   JOURNAL OF MEDICINAL CHEMISTRY

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease

(2009) Alessio Colombo et al.   NEUROBIOLOGY OF DISEASE

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1)

(2008) Yasutomi Asano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2)

(2008) Yasutomi Asano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

(2008) Lijian Hui et al.   JOURNAL OF CLINICAL INVESTIGATION

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

(2008) J. L. Stebbins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA