期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
卷 26, 期 7, 页码 665-671出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ijdevneu.2008.07.016
关键词
Huntington's disease; Apoptosis; Cell cycle; Striatum
资金
- Ministerio de Educacion y Ciencia (Spain) [BFU/2006-11981, SAF2005-01604, SAF-2006-13092]
- Generalitat de Catalunya [2005/SGR00893]
- Universitat de Barcelona
This study was undertaken to investigate the potential role of cell cycle re-entry in an experimental model of Huntington's disease and in human brain samples. We found that after treatment of rats with the mitochondrial neurotoxin 3-nitropropionic acid, the expression of cell cycle markers of G I phase measured by immunohistochemistry was induced in the striatal brain region. Furthermore, we detected an increase in the nuclear and also cytoplasmatic E2F-1 expression, suggesting that this protein could activate the apoptotic cascade in rat brain. Western blot analysis of post-mortem brain samples from patients also showed an increase in the expression of E2F-1 and cyclin D1 in comparison with control samples. These results indicate that cell cycle re-entry is activated in Huntington's disease and may contribute to the neurodegenerative process. (C) 2008 ISDN. Published by Elsevier Ltd. All rights reserved.
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