Article
Biochemistry & Molecular Biology
Sang Eun Ha, Seong Min Kim, Preethi Vetrivel, Hun Hwan Kim, Pritam Bhagwan Bhosale, Jeong Doo Heo, Ho Jeong Lee, Gon Sup Kim
Summary: SCU as a potential agent for HCC therapy inhibits cell proliferation and metastasis in HepG2 cells through upregulation of PTEN and inhibition of the PI3K/Akt/NF-kappa B signaling pathway. It is a natural based agent that shows promise in improving therapeutic outcomes for HCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Si Chen, Fangyuan Shao, Jianming Zeng, Sen Guo, Lijian Wang, Heng Sun, Josh Haipeng Lei, Xueying Lyu, Shuai Gao, Qiang Chen, Kai Miao, Xiaoling Xu, Chu-Xia Deng
Summary: This study identified Cullin-5 as a tumor suppressor that acts synergistically with Brca1 deficiency to promote tumorigenesis. Cullin-5 deficiency activated CREB1-CCL2 signaling, leading to an accumulation of suppressor cells and a reduction of T cells in the tumor microenvironment. Blocking CREB1 activity suppressed changes in the tumor microenvironment caused by Cullin-5 deficiency and blocked tumor progression.
Article
Food Science & Technology
Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Summary: The study highlights the protective effect of Nuciferine (Nuf) against osteoarthritis (OA) by reducing extracellular matrix degradation and inhibiting the production of inflammatory cytokines. Nuf attenuates OA progression by targeting the PI3K/Akt/NF-kappa B signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Integrative & Complementary Medicine
Wu Yi, Ma Yi, Li Jing, Zhou Xue-Lin, Li Lei, Xu Ping-Xiang, Li Xiao-Rong, Xue Ming
Summary: The study revealed that Salidroside could increase the expression of CK2, induce the phosphorylation and inactivation of PTEN, reduce the inhibitory effect on PI3K signaling pathways, and activate the PI3K/Akt/NF-kappa B survival signaling pathway, demonstrating significant protective effects.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Jiayao Qu, Jia Li, Yaming Zhang, Rongzhang He, Xiangting Liu, Ke Gong, Lili Duan, Weihao Luo, Zheng Hu, Gengsheng Wang, Chenglai Xia, Dixian Luo
Summary: Elevated expression of AKR1B10 in breast cancer tissues was associated with lymph node metastasis, tumor size, Ki67 expression, and p53 expression, while inversely correlated with overall and disease-free survival rates. AKR1B10 promotes proliferation, migration, and invasion of breast cancer cells via the PI3K/AKT/NF-kappa B signaling pathway, indicating its potential as a prognostic indicator and therapeutic target in breast cancer.
CELL AND BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yongguang Zhang, Dongya Cui, Miaohui Huang, Yongwei Zheng, Baijiao Zheng, Liling Chen, Qi Chen
Summary: The protein NONO is a multifunctional nuclear protein that regulates transcriptional regulation, mRNA splicing, and DNA repair. This study shows that NONO has a critical role in B-cell development and B-cell activation. Deletion of NONO impairs early B-cell development and B-cell maturation, as well as the activation of pathways involved in B-cell activation, such as ERK, AKT, and NF-kappa B.
Article
Multidisciplinary Sciences
Curtis J. Pritzl, Dezzarae Luera, Karin M. Knudson, Michael J. Quaney, Michael J. Calcutt, Mark A. Daniels, Emma Teixeiro
Summary: The authors demonstrate that modulating NFκB signaling in T cells affects the formation and maintenance of CD8(+) T cell tissue resident memory in the lungs after influenza infection. CD8(+) T cell tissue resident memory is crucial for controlling pathogen spread in the lungs, and NFκB signaling plays a key role in this process.
NATURE COMMUNICATIONS
(2023)
Review
Hematology
Wendan Xu, Philipp Berning, Georg Lenz
Summary: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous diagnostic category, with roughly one-third of patients not cured by standard treatments. BCR signaling and the PI3K pathway are proposed as potential targets for the treatment of DLBCL patients.
Article
Multidisciplinary Sciences
Veronika Ecker, Martina Stumpf, Lisa Brandmeier, Tanja Neumayer, Lisa Pfeuffer, Thomas Engleitner, Ingo Ringshausen, Nina Nelson, Manfred Juecker, Stefan Wanninger, Thorsten Zenz, Clemens Wendtner, Katrin Manske, Katja Steiger, Roland Rad, Markus Mueschen, Juergen Ruland, Maike Buchner
Summary: Current therapeutic approaches in CLL focus on suppressing the PI3K/AKT signaling pathway, but research shows that CLL cells are vulnerable to hyperactivation of this pathway, which may be a promising concept for CLL therapy.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Xin Chen, Qian Lin Song, Jia Yu Wang, Rui Ji, Ming Liang Cao, Duan Ying Guo, Yan Zhang, Jing Yang
Summary: This study demonstrates the involvement of FK506-binding protein 5 (FKBP5) in recurrent spontaneous abortion (RSA), suggesting its potential as a diagnostic and therapeutic target. FKBP5 upregulation at the placental interface contributes to the pathogenesis of RSA by impairing trophoblast function and promoting M1-type macrophage polarization. FKBP5 inhibits trophoblast IL-6 secretion and suppresses trophoblast function through the PI3K/AKT signaling pathway. Moreover, FKBP5 promotes M1 macrophage polarization in decidual macrophages via the ROS/NF-kappa B signaling pathway. FKBP5 inhibitors improve embryo resorption rate in a mouse model of miscarriage, emphasizing the importance of FKBP5 in maintaining pregnancy and trophoblast-macrophage crosstalk at the maternal-fetal interface.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Oncology
Fan Xu, Jiali Wang, Shuman Zhen, Yuqing Duan, Qingshan Li, Lihua Liu
Summary: The stemness characteristic of breast cancer is important for cancer recurrence and metastasis. This study found that C1ql4 is highly expressed in breast cancer tissues and cell lines, and its high expression is significantly correlated with malignancy. Mechanistically, C1ql4 promotes breast cancer cell stemness and EMT through the PI3K/AKT/NF-kB signaling pathway. Therefore, C1ql4 might be a potential target for breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zhen Ye, Yuzheng Li, Yingqi She, Mingquan Wu, Yu Hu, Kaihua Qin, Linzhen Li, Han Yu, Qian Zhao, Zhao Jin, Fating Lu, Qiaobo Ye
Summary: This study investigated the potential active components and molecular mechanisms of Renshen Baidu powder (RSBDP) for the treatment of ulcerative colitis. Results showed that RSBDP could ameliorate disease activity index, colon weight, colon shortening, and histology in TNBS-induced colitis rats. Furthermore, RSBDP inhibited the PI3K/Akt/NF-kappa B signaling pathway to effectively alleviate colitis in rats.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Mark A. Daniels, Dezzarae Luera, Emma Teixeiro
Summary: Memory T cells are crucial in protecting against infectious diseases and cancer, but their generation and maintenance are not fully understood. This review focuses on the role of the NF kappa B signaling system in generating and maintaining CD8 T cell memory, and highlights the remaining questions in this field.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Zhangping He, Jian Xiao, Jianye Wang, Simin Lu, Kang Zheng, Maoying Yu, Jie Liu, Chuan Wang, Nan Ding, Mingxing Liang, Yimou Wu
Summary: CPSIT_0556 inhibits hPMN apoptosis through the PI3K/Akt and NF-kappa B signaling pathways by releasing IL-8, delaying procaspase-3 processing, and regulating the expression of apoptosis-related proteins, providing new insights into the molecular pathogenesis and immune escape mechanisms of C. psittaci.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Soudeh Ghafouri-Fard, Zahra Bahroudi, Hamed Shoorei, Bashdar Mahmud Hussen, Seyedeh Fahimeh Talebi, Sadia Ghousia Baig, Mohammad Taheri, Seyed Abdulmajid Ayatollahi
Summary: Resveratrol is a natural phenol that is present in various fruits and plants. It has potential beneficial effects in diverse pathological conditions and can modulate the expression of genes and the activity of signaling pathways.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Ryan J. Atkins, Stanley S. Stylli, Natalie Kurganovs, Stefano Mangiola, Cameron J. Nowell, Thomas M. Ware, Niall M. Corcoran, Daniel V. Brown, Andrew H. Kaye, Andrew Morokoff, Rodney B. Luwor, Christopher M. Hovens, Theo Mantamadiotis
EXPERIMENTAL CELL RESEARCH
(2019)
Review
Cell Biology
Nok Him Fung, Corrina A. Grima, Samuel S. Widodo, Andrew H. Kaye, Clarissa A. Whitehead, Stanley S. Stylli, Theo Mantamadiotis
CELLULAR SIGNALLING
(2019)
Review
Medical Laboratory Technology
Clarissa A. Whitehead, Andrew H. Kaye, Katharine J. Drummond, Samuel S. Widodo, Theo Mantamadiotis, Laura J. Vella, Stanley S. Stylli
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2020)
Review
Immunology
Alexander James Sedgwick, Nazanin Ghazanfari, Patrick Constantinescu, Theo Mantamadiotis, Alexander David Barrow
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Oncology
Marija Dinevska, Natalia Gazibegovic, Andrew P. Morokoff, Andrew H. Kaye, Katharine J. Drummond, Theo Mantamadiotis, Stanley S. Stylli
Review
Oncology
Samuel S. Widodo, Ryan A. Hutchinson, Yitong Fang, Stefano Mangiola, Paul J. Neeson, Phillip K. Darcy, Alexander D. Barrow, Christopher M. Hovens, Marija Dinevska, Stanley S. Stylli, Theo Mantamadiotis
Summary: Recent developments in cancer immunotherapy offer hope for cancer patients, but difficult to treat cancers such as malignant brain cancer still present challenges, with immune cells in the tumor microenvironment playing a crucial role in regulating tumor immune suppression.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Oncology
Samuel S. Widodo, Marija Dinevska, Liam M. Furst, Stanley S. Stylli, Theo Mantamadiotis
Summary: The prognosis for patients with GBM is very poor despite current standard treatments. The immunosuppressive tumour microenvironment hinders the development of effective immunotherapies for GBM, and understanding the role of IL-10 in GBM is crucial for improving immunotherapy.
BRITISH JOURNAL OF CANCER
(2021)
Review
Oncology
Michael O'Rawe, Ethan J. Kilmister, Theo Mantamadiotis, Andrew H. Kaye, Swee T. Tan, Agadha C. Wickremesekera
Summary: Glioblastoma (GB) is an aggressive brain tumor with poor prognosis despite extensive research. The renin-angiotensin system (RAS) plays a critical role in influencing cancer stem cells and tumor microenvironment in GB. Targeting RAS with existing medications presents a potential new therapeutic strategy for GB treatment.
Article
Cell Biology
Dylan Jones, Clarissa A. Whitehead, Marija Dinevska, Samuel S. Widodo, Liam M. Furst, Andrew P. Morokoff, Andrew H. Kaye, Katharine J. Drummond, Theo Mantamadiotis, Stanley S. Stylli
Summary: Glioblastoma is a highly invasive and destructive brain tumor, and current standard treatments often fail to effectively eliminate it. In this study, we investigate the effects of several FDA-approved drugs on the invasion and viability of GBM cells. We found that these drugs can reduce cell invasion and viability, suggesting their potential as therapeutic options for GBM.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Oncology
Marija Dinevska, Samuel S. Widodo, Liam Furst, Lucero Cuzcano, Yitong Fang, Stefano Mangiola, Paul J. Neeson, Phillip K. Darcy, Robert G. Ramsay, Ryan Hutchinson, Fabienne MacKay, Michael Christie, Stanley S. Stylli, Theo Mantamadiotis
Summary: Tumor microenvironment in malignant astrocytoma undergoes changes in cell composition, cell signaling activation, and extracellular matrix deposition during disease progression. Targeting the extracellular matrix and cell signaling activation will be critical in designing personalized therapy.
Review
Oncology
Padmashree Rao, Liam Furst, Deborah Meyran, Chelsea Mayoh, Paul J. Neeson, Rachael Terry, Dong-Anh Khuong-Quang, Theo Mantamadiotis, Paul G. Ekert
Summary: Pediatric brain tumors are the most common solid tumor in children, and current treatments include surgery, chemotherapy, and radiotherapy. Immunotherapy, especially CAR T cell therapy, may provide new avenues for improved outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Sarah A. Cain, Bernard Pope, Stefano Mangiola, Theo Mantamadiotis, Katharine J. Drummond
Summary: This study aimed to identify somatic mutations and copy number alterations associated with grade progression in meningiomas. Through targeted next-generation sequencing, mutations and CNAs associated with different grade progression were found. NF2 mutations played an important role in grade progression.
Article
Oncology
Clarissa A. Whitehead, Haoyun Fang, Huaqi Su, Andrew P. Morokoff, Andrew H. Kaye, Eric Hanssen, Cameron J. Nowell, Katharine J. Drummond, David W. Greening, Laura J. Vella, Theo Mantamadiotis, Stanley S. Stylli
Summary: In this study, it was found that glioblastoma cells promote invadopodia activity by secreting small extracellular vesicles (sEVs) containing matrix metalloproteinase MMP-2. Additionally, the invasiveness of cells and sEV secretion were increased after radiotherapy/temozolomide treatment. These findings reveal a relationship between sEVs and invadopodia, providing important insights into the functional capacity of sEVs in promoting glioblastoma cell invasion.
Article
Developmental Biology
Tom C. Karagiannis, Christian Orlowski, Katherine Ververis, Eleni Pitsillou, Gulcan Sarila, Samuel T. Keating, Laura J. Foong, Stefanie Fabris, Christina Ngo-Nguyen, Neha Malik, Jun Okabe, Andrew Hung, Theo Mantamadiotis, Assam El-Osta
Summary: This study investigates the role of phosphorylated histone H2AX (gamma H2AX) as a marker of DNA double-strand breaks (DSBs) and its implication in stem cell differentiation. The research establishes a mouse embryonic stem cell (mESC) differentiation model and examines the dynamics of gamma H2AX foci during the process. The findings reveal that gamma H2AX serves as a versatile marker of DSBs and may have a role as a biomarker in stem cell differentiation.
CELLS & DEVELOPMENT
(2024)
Review
Biochemistry & Molecular Biology
Simon Haron, Ethan J. Kilmister, Paul F. Davis, Stanley S. Stylli, Theo Mantamadiotis, Andrew H. Kaye, Sean R. Hall, Swee T. Tan, Agadha C. Wickremesekera
Summary: The Renin-Angiotensin System (RAS) plays a crucial role in both CNS tumors and degenerative diseases by regulating various signaling pathways that affect cellular functions and the development of diseases.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)