Dual Role of Triptolide in Interrupting the NLRP3 Inflammasome Pathway to Attenuate Cardiac Fibrosis

sRAGE attenuates angiotensin II-induced cardiomyocyte hypertrophy by inhibiting RAGE-NFκB-NLRP3 activation

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Extracellular matrix remodeling and cardiac fibrosis

(2018) Li Li et al.   MATRIX BIOLOGY

A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling

(2017) Leonardo Schirone et al.   Oxidative Medicine and Cellular Longevity

Triptolide mitigates radiation-induced pulmonary fibrosis via inhibition of axis of alveolar macrophages-NOXes-ROS-myofibroblasts

(2016) Chun Chen et al.   CANCER BIOLOGY & THERAPY

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

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The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

(2016) Deepika Sharma et al.   JOURNAL OF CELL BIOLOGY

Protective effects of triptolide on TLR4 mediated autoimmune and inflammatory response induced myocardial fibrosis in diabetic cardiomyopathy

(2016) Xin Guo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Triptolide Upregulates Myocardial Forkhead Helix Transcription Factor p3 Expression and Attenuates Cardiac Hypertrophy

(2016) Yuan-Yuan Ding et al.   Frontiers in Pharmacology

NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy

(2015) Koumei Shirasuna et al.   ENDOCRINOLOGY

The ImageJ ecosystem: An open platform for biomedical image analysis

(2015) Johannes Schindelin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

NLRP3 inflammasome and its inhibitors: a review

(2015) Bo-Zong Shao et al.   Frontiers in Pharmacology

Biochemical and structural aspects of the ATP-binding domain in inflammasome-forming human NLRP proteins

(2015) Justin A. MacDonald et al.   IUBMB LIFE

Cardiac fibroblasts support cardiac inflammation in heart failure

(2014) Diana Lindner et al.   BASIC RESEARCH IN CARDIOLOGY

Inflammasome: Putting the Pieces Together

(2014) Jürgen Ruland   CELL

Structural mechanisms in NLR inflammasome signaling

(2014) Bernhard C Lechtenberg et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

NLRP3 Inflammasome as a Novel Player in Myocardial Infarction

(2014) Masafumi Takahashi   International Heart Journal

Mitochondrial NLRP3 Protein Induces Reactive Oxygen Species to Promote Smad Protein Signaling and Fibrosis Independent from the Inflammasome

(2014) Nathan A. Bracey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The pathogenesis of cardiac fibrosis

(2013) Ping Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Triptolide protects rat heart against pressure overload-induced cardiac fibrosis

(2013) Zhengang Zhang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Mechanisms of Cardiac Fibrosis in Inflammatory Heart Disease

(2010) Gabriela Kania et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Cardiac fibroblasts: At the heart of myocardial remodeling

(2009) Karen E. Porter et al.   PHARMACOLOGY & THERAPEUTICS