Article
Oncology
Shiqin Liu, Busola Ruth Alabi, Qingqing Yin, Tanya Stoyanova
Summary: Prostate cancer is a common cancer in men in the United States and often leads to cancer-related deaths. Androgen deprivation therapy is the standard treatment for advanced prostate cancer, but some patients develop castration-resistant prostate cancer and even neuroendocrine prostate cancer. Neuroendocrine prostate cancer is characterized by the expression of neuroendocrine markers and the absence of androgen receptor, and is often associated with aggressive tumors, therapy resistance, and poor clinical outcomes.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Pathology
Fei Li, Xiuwei Chen
Summary: Long-stranded non-coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that play a significant role in various biological processes. Aberrant expression of lncRNAs, such as TRPM2-AS, is closely related to human cancer occurrence and poor clinical outcomes. TRPM2-AS acts as a ceRNA, participates in signaling pathways, interacts with biological proteins and other molecular mechanisms, and regulates gene expression, as well as cancer cell proliferation, migration, invasion, apoptosis, and treatment resistance. It could be a potential target and biomarker for cancer treatment and prognosis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Medicine, General & Internal
Grazyna Sygitowicz, Agata Maciejak-Jastrzebska, Dariusz Sitkiewicz
Summary: The cellular and molecular mechanisms underlying atrial fibrosis are complex, involving various signaling pathways and molecular factors. The Ang-II-MAPK and TGFβ1-Smad signaling pathways are identified as playing key roles in regulating atrial fibrotic remodeling.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Nadia Salerno, Giuseppe Panuccio, Jolanda Sabatino, Isabella Leo, Michele Torella, Sabato Sorrentino, Salvatore De Rosa, Daniele Torella
Summary: Tricuspid valve (TV) disease is highly prevalent and has received significant attention in recent years. Comprehensive knowledge of molecular and cellular mechanisms underlying TV development and disease is necessary for better understanding and treatment of tricuspid regurgitation patients. Scientific efforts are still needed to fully understand the etiopathogenesis of TV and TV-associated cardiomyopathy, and future advances may come from combining diagnostic imaging with molecular and cellular studies. Basic science research could provide the basis for innovative valve repair and regeneration using tissue-engineered heart valves.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Kijeong Lee, Junhu Tai, Sang Hag Lee, Tae Hoon Kim
Summary: Chronic rhinosinusitis (CRS) is a chronic inflammatory condition affecting up to 10% of the population worldwide, with differences in tissue remodeling based on clinical phenotype and underlying pathophysiologic mechanisms. Eosinophilic CRS and non-eosinophilic CRS are also classified based on immune response types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ho-Wei Hsu, Ting-Yi Lin, Yi-Ching Liu, Jwu-Lai Yeh, Jong-Hau Hsu
Summary: The ductus arteriosus plays a crucial role in fetal circulation and is usually regulated by the prostaglandin pathway. Some patients, however, do not respond to prostaglandin-targeting medications and require surgical intervention. Therefore, studying molecules independent from the prostaglandin pathway is important for future clinical management of ductus arteriosus patency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Hinda Allaoui, Nedra Rached, Naziha Marrakchi, Ameur Cherif, Amor Mosbah, Erij Messadi
Summary: The natriuretic-like peptide Lebetin 2 (L2) has been found to exert potent cardioprotection in myocardial infarction, with stronger effects than B-type natriuretic peptide (BNP). Through molecular modeling and simulation, it was discovered that L2 exhibited higher affinity for NP receptors (NPRs), particularly NPR-A and NPR-C, compared to BNP. The stronger interaction between L2 and NPR-C suggests a potential new signaling pathway. Overall, L2 shows promise as a therapeutic approach for myocardial infarction and highlights the importance of further research.
Review
Pharmacology & Pharmacy
Nor Hidayah Mustafa, Juriyati Jalil, Satirah Zainalabidin, Mohammed S. M. Saleh, Ahmad Yusof Asmadi, Yusof Kamisah
Summary: Cardiovascular diseases are a significant clinical burden worldwide, and heart failure is a common disease resulting from uncontrolled hypertension. Sacubitril/valsartan, a new drug combination, has been approved for patients with heart failure, but its molecular mechanism of action in cardiac remodeling is still unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Plant Sciences
Zhixin Zhang, Lin Yang, Jiaming Hou, Shaokai Tian, Ying Liu
Summary: Licorice flavonoids demonstrate anticancer activities by inhibiting cancer cells through regulating cell cycle and multiple signaling pathways. They have pleiotropic effects on cell growth, survival, and signaling, showing great therapeutic potential in cancer treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Cell Biology
Laura Faith George, Emily Anne Bates
Summary: Communication between cells during development is crucial, and growing evidence suggests that bioelectric signals controlled by ion channels play an important role in this process. Ion channels regulate various cellular processes and developmental signaling pathways. Bioelectricity contributes to development through multiple mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Evanthia Tourkochristou, Stelios F. Assimakopoulos, Konstantinos Thomopoulos, Markos Marangos, Christos Triantos
Summary: Non-alcoholic fatty liver disease (NAFLD) and Hepatitis B virus infection (HBV) are common chronic liver diseases with worldwide distribution. The co-occurrence of both diseases has gained great research and clinical interest. Despite the organized HBV vaccinations and use of anti-viral therapies globally, HBV infection remains endemic and challenging public health issue.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Kisha Pradhan, Ziyue Yi, Shuo Geng, Liwu Li
Summary: This study investigated the generation of exhausted monocytes in murine models through prolonged challenges with high dose LPS, leading to skewing of monocytes towards classically exhausted Ly6C(hi) population and depletion of non-classical Ly6C(lo) population. Findings revealed CD38 as an inflammatory mediator and STAT1 as a crucial factor in the mechanism of monocyte exhaustion.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Genetics & Heredity
Ying Liu, Yiwen Li, Chengcheng Du, Shouxiang Kuang, Xuehao Zhou, Jinyu Zhang, Xiang Ao
Summary: Cancer, the second-leading cause of global mortality, remains a major obstacle to human life extension. Epithelial splicing regulatory proteins (ESRPs), belonging to the RNA-binding proteins family, play a crucial role in alternative splicing of messenger RNAs (mRNAs) and are closely associated with cancer progression. Despite the inconclusive mechanisms, ESRPs have potential clinical implications as prognostic biomarkers and therapeutic targets in cancer treatment.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Medicine, Research & Experimental
Hussain Al Dera
Summary: This paper reviews the major molecular mechanisms responsible for the clinical symptoms seen in people with ASD, including genetic factors, neuroinflammation, neurotransmitter signaling, and calcium signaling. It also covers the molecular mechanisms underlying epileptic seizures and sleep disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Raghu Ram Katreddi, Paolo E. Forni
Summary: The VNO is a sensory organ in rodents, developing from the olfactory placode during embryonic stage. While most vertebrate species have a VNO structure, many species including humans do not have a functional VNO after birth. VSNs in the VNO express different receptors and play a role in the accessory olfactory system coordinating social and sexual behaviors.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Carmine Izzo, Valeria Visco, Jessica Gambardella, Germano Junior Ferruzzi, Antonella Rispoli, Maria Rosaria Rusciano, Anna Laura Toni, Nicola Virtuoso, Albino Carrizzo, Paola Di Pietro, Guido Iaccarino, Carmine Vecchione, Michele Ciccarelli
Summary: The COVID-19 pandemic caused by SARS-CoV-2 is a global challenge, with cardiovascular involvement being a crucial complication. This report discusses the role of microRNAs in cardiovascular complications associated with COVID-19, highlighting their potential as biomarkers and predictors of cardiac and vascular damage.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Editorial Material
Cell & Tissue Engineering
Claudia Cozzolino, Vittorio Picchio, Erica Floris, Francesca Pagano, Wael Saade, Mariangela Peruzzi, Giacomo Frati, Isotta Chimenti
Summary: Smoking habits have a significant impact on cardiovascular health by damaging differentiated and functional cells, as well as impairing reparative mechanisms. The introduction of modified tobacco risk products (MRPs) as alternative smoking devices has raised concerns regarding their effects on cardiovascular repair and regenerative cells. This review critically evaluates the limited available data on the molecular and cellular effects of MRPs on cardiovascular repair and regeneration.
CURRENT STEM CELL RESEARCH & THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Monica Cattaneo, Antonio P. Beltrami, Anita C. Thomas, Gaia Spinetti, Valeria Vincenza Alvino, Elisa Avolio, Claudia Veneziano, Irene Giulia Rolle, Sandro Sponga, Elena Sangalli, Anna Maciag, Fabrizio Dal Piaz, Carmine Vecchione, Aishah Alenezi, Stephen Paisey, Annibale A. Puca, Paolo Madeddu
Summary: The longevity-associated variant of the BPIFB4 gene, known as LAV-BPIFB4, can improve heart function and perfusion in older people, and prevent the decline of heart performance. Gene therapy with LAV-BPIFB4 can reverse the age-related decline in cardiac function, improve microvasculature density and pericyte coverage.
CARDIOVASCULAR RESEARCH
(2023)
Article
Nutrition & Dietetics
Alessandra D'Amico, Chiara Fossati, Fabio Pigozzi, Paolo Borrione, Mariangela Peruzzi, Simona Bartimoccia, Filippo Saba, Annachiara Pingitore, Giuseppe Biondi-Zoccai, Luigi Petramala, Fabrizio De Grandis, Daniele Vecchio, Luca D'Ambrosio, Sonia Schiavon, Luigi Sciarra, Cristina Nocella, Elena Cavarretta
Summary: This study aimed to investigate the effects of a mixture containing three compounds on muscle injury biomarkers in endurance athletes. The results showed that the intake of this mixture significantly reduced oxidative stress and positively modulated autophagy, resulting in a significant decrease in muscle injury biomarkers.
Article
Cardiac & Cardiovascular Systems
Carla Letizia Busceti, Albino Carrizzo, Franca Bianchi, Massimiliano De Lucia, Antonio Damato, Chiara Cazzin, Eleonora Venturini, Paola Di Pietro, Roxana Paula Ginerete, Luisa Di Menna, Maria Cotugno, Rosita Stanzione, Simona Marchitti, Serena Migliarino, Michele Ciccarelli, Sebastiano Sciarretta, Valeria Bruno, Giuseppe Battaglia, Francesco Fornai, Massimo Volpe, Speranza Rubattu, Ferdinando Nicoletti, Carmine Vecchione
Summary: Dkk3 plays a crucial role in cardiovascular homeostasis, and its deficiency leads to hypertension and impaired vascular function, which can be rescued by restoring Dkk3 expression. This effect is achieved through promoting VEGF expression and activating the VEGF/Akt/eNOS hypotensive pathway.
CIRCULATION RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Paola Di Pietro, Carmine Vecchione, Albino Carrizzo
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Michele Ciccarelli, Francesco Giallauria, Albino Carrizzo, Valeria Visco, Angelo Silverio, Arturo Cesaro, Paolo Calabro, Nicola De Luca, Costantino Mancusi, Daniele Masarone, Giuseppe Pacileo, Nidal Tourkmani, Carlo Vigorito, Carmine Vecchione
Summary: The use of artificial intelligence in cardiovascular disease has been increasingly recognized for its ability to provide valuable patient-centric insights and improve diagnosis and treatment through the analysis of real-world data.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Angelo Silverio, Francesco Paolo Cancro, Luca Esposito, Michele Bellino, Debora D'Elia, Monica Verdoia, Maria Giovanna Vassallo, Michele Ciccarelli, Carmine Vecchione, Gennaro Galasso, Giuseppe De Luca
Summary: The control of cardiovascular risk factors, promotion of a healthy lifestyle, and antithrombotic therapy are important for secondary prevention after acute coronary syndrome (ACS). Identification of novel risk factors and targets is essential to optimize preventive strategies for patients who have recurrent ischemic events despite optimal control of traditional risk factors and pharmacological therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Michele Bellino, Gennaro Galasso, Angelo Silverio, Michele Tedeschi, Ciro Formisano, Stefano Romei, Luca Esposito, Francesco Paolo Cancro, Maria Giovanna Vassallo, Giulio Accarino, Monica Verdoia, Francesca Maria Di Muro, Carmine Vecchione, Giuseppe De Luca
Summary: Current research on cardiovascular prevention focuses on risk-stratification and management of coronary artery disease (CAD) patients. The aim is to determine the causes and risk factors of CAD and to identify ways to counteract them. The role of LDL cholesterol (LDL-C) as a key factor in atherosclerotic cardiovascular disease (ASCVD) has been well established, and inhibiting PCSK9, a regulator of LDL-C levels, has shown promising results in reducing LDL-C.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Analytical
Angela-Tafadzwa Shumba, Teodoro Montanaro, Ilaria Sergi, Alessia Bramanti, Michele Ciccarelli, Antonella Rispoli, Albino Carrizzo, Massimo De Vittorio, Luigi Patrono
Summary: Smart wearable devices enable personalized at-home healthcare by collecting patient health data and facilitating the development of intelligent platforms. Accurate analysis of data obtained from wearables is crucial for interpreting health data and supporting diagnosis and management of diseases. The combination of edge computing and AI provides real-time and privacy-preserving data analysis solutions.
Article
Cardiac & Cardiovascular Systems
Angelo Silverio, Eduardo Bossone, Guido Parodi, Fernando Scudiero, Marco Di Maio, Olga Vriz, Michele Bellino, Concetta Zito, Gennaro Provenza, Giuseppe Iuliano, Mario Cristiano, Giuseppina Novo, Ciro Mauro, Fausto Rigo, Pasquale Innelli, Jorge Salerno-Uriarte, Matteo Cameli, Giuliana Tremiterra, Carmine Vecchione, Francesco Antonini-Canterin, Gennaro Galasso, Rodolfo Citro, Takotsubo Italian Network
Summary: This study aimed to investigate the long-term outcomes of takotsubo syndrome (TTS) patients with and without hypertension (HT), and evaluate the effectiveness of treatment with beta-blockers (BBs) and/or renin-angiotensin-aldosterone system inhibitors (RAASi). The study found that HT does not affect the long-term risk of adverse events in TTS patients, but increases the effectiveness of BB treatment. Therefore, tailored pharmacological therapy should be considered for TTS patients with HT.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Germano Junior Ferruzzi, Angelo Silverio, Arturo Giordano, Nicola Corcione, Michele Bellino, Tiziana Attisano, Cesare Baldi, Alberto Morello, Giuseppe Biondi-Zoccai, Rodolfo Citro, Carmine Vecchione, Gennaro Galasso
Summary: This study found that the presence of moderate to severe mitral regurgitation (MR) in patients with low flow, low-gradient aortic stenosis undergoing transcatheter aortic valve replacement (TAVR) is associated with a worse clinical outcome at 1 year. TAVR may improve MR severity in some patients, resulting in potential benefits after discharge.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Endocrinology & Metabolism
Paola Di Pietro, Carmine Izzo, Albino Carrizzo
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Davide Bellini, Marika Milan, Antonella Bordin, Roberto Rizzi, Marco Rengo, Simone Vicini, Alessandro Onori, Iacopo Carbone, Elena De Falco
Summary: Radiomics is a novel advanced approach to imaging, extracting quantitative and reproducible data from radiological images using sophisticated mathematical analysis. Radiogenomics, defined as the integration of radiology and genomics, explores the relationship between specific features extracted from radiological images and genetic or molecular traits of a particular disease. Despite advancements, standardized protocols in clinical practice are still lacking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)