Mitochondrial NLRP3 Protein Induces Reactive Oxygen Species to Promote Smad Protein Signaling and Fibrosis Independent from the Inflammasome

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury

(2013) Øystein Sandanger et al.   CARDIOVASCULAR RESEARCH

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Cell Therapy Limits Myofibroblast Differentiation and Structural Cardiac Remodeling

(2012) Paul W.M. Fedak et al.   Circulation-Heart Failure

The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β

(2012) Nathan A. Bracey et al.   EXPERIMENTAL PHYSIOLOGY

Mitochondrial Reactive Oxygen Species Regulate Transforming Growth Factor-β Signaling

(2012) Manu Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammasome-Independent NLRP3 Augments TGF-  Signaling in Kidney Epithelium

(2012) W. Wang et al.   JOURNAL OF IMMUNOLOGY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Deletion of the Innate Immune NLRP3 Receptor Abolishes Cardiac Ischemic Preconditioning and Is Associated with Decreased Il-6/STAT3 Signaling

(2012) Coert J. Zuurbier et al.   PLoS One

The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis

(2011) Carol M. Artlett et al.   ARTHRITIS AND RHEUMATISM

Syndecan-4 Prevents Cardiac Rupture and Dysfunction After Myocardial Infarction

(2011) Yutaka Matsui et al.   CIRCULATION RESEARCH

Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload

(2011) Norimichi Koitabashi et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

(2010) A. A. Shigeoka et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix

(2009) D. Arnoult et al.   JOURNAL OF CELL SCIENCE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Myocardial remodeling after infarction: the role of myofibroblasts

(2009) Susanne W. M. van den Borne et al.   Nature Reviews Cardiology

NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production

(2008) Ivan Tattoli et al.   EMBO REPORTS