Let-7 microRNA as a potential therapeutic target with implications for immunotherapy

MicroRNA let-7c-5p improves neurological outcomes in a murine model of traumatic brain injury by suppressing neuroinflammation and regulating microglial activation

(2018) Jingfang Lv et al.   BRAIN RESEARCH

Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients

(2018) Shuai Jiang et al.   Cell Metabolism

Tapping the RNA world for therapeutics

(2018) Judy Lieberman   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tapping the RNA world for therapeutics

(2018) Judy Lieberman   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Knockdown of MicroRNA Let-7a Improves the Functionality of Bone Marrow-Derived Mesenchymal Stem Cells in Immunotherapy

(2017) Yang Yu et al.   MOLECULAR THERAPY

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

The X chromosome in space

(2017) Teddy Jégu et al.   NATURE REVIEWS GENETICS

DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA–gene interactions

(2017) Dimitra Karagkouni et al.   NUCLEIC ACIDS RESEARCH

Cellular microRNA networks regulate host dependency of hepatitis C virus infection

(2017) Qisheng Li et al.   Nature Communications

Molecular Control of Innate Immune Response to Pseudomonas aeruginosa Infection by Intestinal let-7 in Caenorhabditis elegans

(2017) Lingtong Zhi et al.   PLoS Pathogens

Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells

(2017) Alexandria C Wells et al.   eLife

Inhibition of the Let-7 Family MicroRNAs Induces Cardioprotection Against Ischemia-Reperfusion Injury in Diabetic Rats

(2016) Juchen Li et al.   ANNALS OF THORACIC SURGERY

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b

(2016) Sita Kugel et al.   CELL

Aromatase inhibitor regulates let-7 expression and let-7f–induced cell migration in endometrial cells from women with endometriosis

(2016) SiHyun Cho et al.   FERTILITY AND STERILITY

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

(2016) Muhammad S. Beg et al.   INVESTIGATIONAL NEW DRUGS

Targeting microRNAs as key modulators of tumor immune response

(2016) Laura Paladini et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inhibition of let-7 augments the recruitment of epicardial cells and improves cardiac function after myocardial infarction

(2016) Timon Seeger et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MicroRNA let-7, T Cells, and Patient Survival in Colorectal Cancer

(2016) R. Dou et al.   Cancer Immunology Research

EpiBrainRad: an epidemiologic study of the neurotoxicity induced by radiotherapy in high grade glioma patients

(2015) Thomas Durand et al.   BMC Neurology

MicroRNA let-7 Modulates the Immune Response to Mycobacterium tuberculosis Infection via Control of A20, an Inhibitor of the NF-κB Pathway

(2015) Manish Kumar et al.   Cell Host & Microbe

Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function

(2015) Leonid A Pobezinsky et al.   NATURE IMMUNOLOGY

Inhibition of c-Myc by let-7b mimic reverses mutidrug resistance in gastric cancer cells

(2015) XIAOJUN YANG et al.   ONCOLOGY REPORTS

Let-7 Sensitizes KRAS Mutant Tumor Cells to Chemotherapy

(2015) Xin Dai et al.   PLoS One

Caenorhabditis elegansmicroRNAs of thelet-7family act in innate immune response circuits and confer robust developmental timing against pathogen stress

(2015) Zhiji Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i

(2014) Hongguan Xie et al.   HUMAN IMMUNOLOGY

MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells

(2014) Isobel S. Okoye et al.   IMMUNITY

microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells

(2014) Antoine Marcais et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA silencing for cancer therapy targeted to the tumour microenvironment

(2014) Christopher J. Cheng et al.   NATURE

In Vitro and In Vivo Activity of a Novel Locked Nucleic Acid (LNA)-Inhibitor-miR-221 against Multiple Myeloma Cells

(2014) Maria Teresa Di Martino et al.   PLoS One

PreImplantation factor promotes neuroprotection by targeting microRNA let-7

(2014) M. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs in Immune Response and Macrophage Polarization

(2013) Gang Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MicroRNA let-7c Regulates Macrophage Polarization

(2013) S. Banerjee et al.   JOURNAL OF IMMUNOLOGY

High-Throughput Profiling of Alpha Interferon- and Interleukin-28B-Regulated MicroRNAs and Identification of let-7s with Anti-Hepatitis C Virus Activity by Targeting IGF2BP1

(2013) M. Cheng et al.   JOURNAL OF VIROLOGY

Let-7b Is Involved in the Inflammation and Immune Responses Associated with Helicobacter pylori Infection by Targeting Toll-Like Receptor 4

(2013) Gui-gen Teng et al.   PLoS One

Differential Regulation of the Let-7 Family of MicroRNAs in CD4+ T Cells Alters IL-10 Expression

(2012) S. Swaminathan et al.   JOURNAL OF IMMUNOLOGY

MicroRNA Let-7i Is a Promising Serum Biomarker for Blast-Induced Traumatic Brain Injury

(2012) Nagaraja Balakathiresan et al.   JOURNAL OF NEUROTRAUMA

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma

(2012) I. A. Babar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lin28b Reprograms Adult Bone Marrow Hematopoietic Progenitors to Mediate Fetal-Like Lymphopoiesis

(2012) Joan Yuan et al.   SCIENCE

A let-7/Fas double-negative feedback loop regulates human colon carcinoma cells sensitivity to Fas-related apoptosis

(2011) Li Geng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Analysis of the host microRNA response toSalmonellauncovers the control of major cytokines by thelet-7family

(2011) Leon N Schulte et al.   EMBO JOURNAL

Expression of let-7i is associated with Toll-like receptor 4 signal in coronary artery disease: Effect of statins on let-7i and Toll-like receptor 4 signal

(2011) Mamoru Satoh et al.   IMMUNOBIOLOGY

A Cellular MicroRNA, let-7i, Is a Novel Biomarker for Clinical Outcome in Patients With Dilated Cardiomyopathy

(2011) Mamoru Satoh et al.   JOURNAL OF CARDIAC FAILURE

Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

(2011) Phong Trang et al.   MOLECULAR THERAPY

Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs

(2011) R. J. A. Frost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a Lung Cancer Therapeutic Based on the Tumor Suppressor MicroRNA-34

(2010) J. F. Wiggins et al.   CANCER RESEARCH

Thelet-7microRNA reduces tumor growth in mouse models of lung cancer

(2010) Aurora Esquela-Kerscher et al.   CELL CYCLE

Proinflammatory Role forlet-7MicroRNAS in Experimental Asthma

(2010) Sumanth Polikepahad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma

(2010) Pedro P. Medina et al.   NATURE

The role of let-7 in cell differentiation and cancer

(2009) Benjamin Boyerinas et al.   ENDOCRINE-RELATED CANCER

Regression of murine lung tumors by the let-7 microRNA

(2009) P Trang et al.   ONCOGENE

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

(2008) Xi Chen et al.   CELL RESEARCH

Endogenous human microRNAs that suppress breast cancer metastasis

(2008) Sohail F. Tavazoie et al.   NATURE

Suppression of non-small cell lung tumor development by the let-7 microRNA family

(2008) M. S. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The let-7 family of microRNAs

(2008) Sarah Roush et al.   TRENDS IN CELL BIOLOGY

let-7 microRNAs in development, stem cells and cancer

(2008) Ingo Büssing et al.   TRENDS IN MOLECULAR MEDICINE

MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery components

(2007) Ananthi J. Asirvatham et al.   MOLECULAR IMMUNOLOGY