期刊
JOURNAL OF CARDIAC FAILURE
卷 17, 期 11, 页码 923-929出版社
CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
DOI: 10.1016/j.cardfail.2011.07.012
关键词
Endomyocardial biopsy; immune response; left ventricular dysfunction; real-time PCR; Toll-like receptor 4
资金
- Japanese Ministry of Education, Science, Sports, and Culture [20590886]
- Keiryokai Research Foundation [98]
- National Institutes of Health Research (NIHR) [98] Funding Source: National Institutes of Health Research (NIHR)
- Grants-in-Aid for Scientific Research [20590886] Funding Source: KAKEN
Background: Our previous studies have reported that activation of Toll-like receptor (TLR) 4 is implicated in the etiology of human dilated cardiomyopathy (DCM). A recent report has demonstrated that let-7i, a member of the let-7 family of cellular microRNAs (miRs) miR-21, miR-126, and miR-155, directly regulate TLR4 expression. The aim of this study was to determine whether let-7i, miR-21, miR-126, and miR-155 are expressed with TLR4 in human DCM, and whether let-7i levels are related to clinical outcomes. Methods and Results: Endomyocardial biopsy tissues were obtained from 103 patients with DCM and 37 subjects without left ventricular (LV) dysfunction as control subjects. Levels of let-7i, miR-126, and miR-155 were lower in the DCM group than in the controls, whereas levels of miR-21 and TLR4 (both mRNA and protein) were higher in the DCM group than in the control group. Levels of let-7i were negatively correlated with TLR4 protein levels in all subjects. After a mean follow-up period of 509 days, 6 DCM patients (5.8%) had died due to a cardiac cause and 15 (14.6%) had developed heart failure. When patients with DCM were divided into tertiles according to let-7i levels, log-rank analysis showed that the DCM subgroup with low let-7i levels was associated with poor clinical outcomes (P = .02). Conclusions: A decrease in let-7i may be related to poor clinical outcomes in patients with DCM. (J Cardiac Fail 2011;17:923-929)
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