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Ecology
Shaoyang Li, Sylvia Yang Liu, Shepherd Yuen Chan, Song Lin Chua
Summary: Microbes use biofilm cloak as an anti-detection adaptation to hide their chemical trails from predators, which has a fundamental impact on the ecological dynamics of microbial communities and predator-prey interactions.
Article
Immunology
Ruan Fourie, Jacobus Albertyn, Olihile Sebolai, Onele Gcilitshana, Carolina H. Pohl
Summary: The interaction between Candida albicans and Pseudomonas aeruginosa affects early biofilm formation and virulence of C. albicans in an infection model. Deletion of SET3 does not affect C. albicans morphology in the presence of P. aeruginosa, but it reduces virulence in a Caenorhabditis elegans infection model.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Nolan Neville, Nathan Roberge, Xiang Ji, Preyesh Stephen, Jiasheng Louis Lu, Zongchao Jia
Summary: The small molecule gallein was discovered as a dual-specificity inhibitor of both PPK1 and PPK2 enzyme families in Pseudomonas aeruginosa, disrupting cellular polyphosphate accumulation and attenuating biofilm formation, motility, and toxin production. This study establishes PPK2 enzymes as valuable drug targets in P. aeruginosa and provides a promising starting point for the development of new antivirulence therapeutics.
Article
Genetics & Heredity
Charles Nelson, Victor Ambros
Summary: The let-7 gene encodes a highly conserved microRNA crucial for cell fate specification and developmental progression in animals. Some nematode species within the Caenorhabditis genus lack let-7 gene, but they possess let-7-family microRNAs that target LIN-41 mRNA.
G3-GENES GENOMES GENETICS
(2021)
Article
Microbiology
Kasturi Chandra, Atish Roy Chowdhury, Ritika Chatterjee, Dipshikha Chakravortty
Summary: This study reveals the important role of chitinase in Salmonella pathogenesis. It promotes intestinal epithelium remodeling and host system access. In phagocytes, chitinase-mediated upregulation of nitric oxide inhibits MHC-I bound antigen presentation and CD8(+) T cell proliferation. The absence of chitinase impairs bacterial adhesion and colonization. In the murine host, chitinase prevents immune activation and antimicrobial responses. In C. elegans, Salmonella chitinase promotes bacterial attachment to the intestinal epithelium and enhances pathogen colonization and persistence.
Article
Biochemistry & Molecular Biology
Chun Li, Bohyung Yoon, Giovanni Stefani, Frank J. Slack
Summary: This study reveals a novel role for lipid kinase PPK-1/PIP5K1A in regulating miRNA levels. PPK-1/PIP5K1A is able to control the levels of let-7 miRNA in C. elegans and human cells. It interacts with nuclear export protein XPO5 to block the binding of XPO5 to pre-let-7 miRNA, thus regulating the levels of mature miRNA.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mengyao Liu, Nana Li, Shan Shan, Yudong Shi, Yuanbin Zhu, Weihong Lu
Summary: This study revealed the significant role of Acanthopanax senticosus polysaccharide (ASPS) in regulating immune damage caused by radiation. The results showed that ASPS can directly elevate the immune response of nematodes, effectively enhancing their resistance against pathogens in radiation-damaged conditions. Additionally, ASPS also alleviated the stress status of damaged nematodes by regulating oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ecology
Shepherd Yuen Chan, Sylvia Yang Liu, Zijing Seng, Song Lin Chua
Summary: A study found that biofilms produced by the Gram-negative bacterium Pseudomonas aeruginosa can interfere with the motility of bacterivorous nematode Caenorhabditis elegans through the production of a specific exopolysaccharide, Psl. This interference reduces the ability of C. elegans to roam and prey on the biofilms.
Article
Biochemical Research Methods
Xinyi Cheng, Lu Pu, Shengwei Fu, Aiguo Xia, Shuqiang Huang, Lei Ni, Xiaochen Xing, Shuai Yang, Fan Jin
Summary: By reengineering the signal transduction protein GacS of bacterial pathogens using optogenetics, it is possible to spatially and temporally control pathogenicity in host systems, potentially accelerating the development of innovative therapeutics through the creation of new pathogenesis systems in specific tissues.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Deep Prakash, Akhil MS, Buddidhathi Radhika, Radhika Venkatesan, Sreekanth H. Chalasani, Varsha Singh
Summary: The study demonstrates that 1-undecene released by Pseudomonas aeruginosa serves as a pathogen-associated molecular pattern, inducing protective responses in Caenorhabditis elegans by activating odor sensory neurons. This mechanism enhances the nematodes' survival upon subsequent bacterial infection.
Article
Biotechnology & Applied Microbiology
Xiaojuan Tan, Mei Hu, Xi Cheng, Jingjing Xiao, Jinwei Zhou, Guoping Zhu
Summary: By modulating the expression of nitrite reductase encoding gene nirS, elevated intracellular nitric oxide (NO) levels can inhibit P. aeruginosa biofilm growth in chronic skin wounds and reduce its pathogenicity to the host.
INTERNATIONAL MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kim Thomsen, Niels Hoiby, Peter Ostrup Jensen, Oana Ciofu, Claus Moser
Summary: Biofilm infections are resistant to host responses and antibiotics. The host immune response plays a crucial role in the outcome and exacerbation of chronic infections. In chronic Pseudomonas aeruginosa lung infections, antibody response and Th1/Th2 imbalance have been associated with a worse outcome.
Article
Microbiology
Sakthivel Ambreetha, Dananjeyan Balachandar
Summary: This study demonstrates that plant-associated Pseudomonas aeruginosa could pose a potential threat to human health similar to clinical strains. Certain strains isolated from cucumber, tomato, eggplant, and chili exhibited higher virulence and pathogenicity.
Article
Microbiology
Donghoon Kang, Alexey Revtovich, Alexander E. Deyanov, Natalia Kirienko, Patricia A. Bradford
Summary: Pseudomonas aeruginosa is a multidrug-resistant pathogen that causes various infections, and exploring new therapeutic avenues, such as targeting virulence factors, is crucial. Gallium(III) nitrate has been recognized for inhibiting pathogen growth and biofilm formation, but the effectiveness can be limited by pyoverdine. Inhibitors of pyoverdine, such as 5-fluorocytosine and tetracycline, can synergize with gallium nitrate to inhibit P. aeruginosa growth and biofilm formation.
Article
Developmental Biology
Kimberley D. Gauthier, Christian E. Rocheleau
Summary: The LIN-2/7/10 complex in Caenorhabditis elegans plays a crucial role in regulating the localization and signaling of EGFR, with LIN-7 colocalizing with EGFR at the basolateral membrane and the complex itself forming on the Golgi to target EGFR trafficking to the basolateral membrane.
Article
Immunology
Yonglin Yu, Lingtong Zhi, Qiuli Wu, Lina Jing, Dayong Wang
CELLULAR & MOLECULAR IMMUNOLOGY
(2018)
Article
Nanoscience & Nanotechnology
Qiuli Wu, Lingtong Zhi, Yangyang Qu, Dayong Wang
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2016)
Article
Nanoscience & Nanotechnology
Yunli Zhao, Lingtong Zhi, Qiuli Wu, Yonglin Yu, Qiqing Sun, Dayong Wang
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Multidisciplinary Sciences
Yonglin Yu, Lingtong Zhi, Xiangmin Guan, Daoyong Wang, Dayong Wang
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Lingmei Sun, Lingtong Zhi, Shumaila Shakoor, Kai Liao, Dayong Wang
SCIENTIFIC REPORTS
(2016)
Article
Chemistry, Multidisciplinary
Guosheng Xiao, Lingtong Zhi, Xuecheng Ding, Qi Rui, Dayong Wang
Article
Multidisciplinary Sciences
Lingtong Zhi, Yonglin Yu, Zhixia Jiang, Dayong Wang
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Lingtong Zhi, Mingxia Ren, Man Qu, Hanyu Zhang, Dayong Wang
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Changjiang Guo, Xiaoyin Wang, Huiyong Zhang, Lingtong Zhi, Tanyu Lv, Mingfeng Li, Chengui Lu, Wuling Zhu
MOLECULAR IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Mingfeng Li, Lingtong Zhi, Meichen Yin, Changjiang Guo, Huiyong Zhang, Chengui Lu, Wuling Zhu
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Zhang Huiyong, Xia Wenjiao, Liang Chen, Wang Xiaoyin, Zhi Lingtong, Guo Changjiang, Niu Zhiyuan, Zhu Wuling
MOLECULAR IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Chengui Lu, Changjiang Guo, Han Chen, Huiyong Zhang, Lingtong Zhi, Tanyu Lv, Mingfeng Li, Zhiyuan Niu, Ping Lu, Wuling Zhu
MOLECULAR IMMUNOLOGY
(2020)
Article
Chemistry, Physical
Lingtong Zhi, Man Qu, Mingxia Ren, Li Zhao, Yunhui Li, Dayong Wang
Article
Chemistry, Multidisciplinary
Lingtong Zhi, Wei Fu, Xiong Wang, Dayong Wang