Article
Immunology
Wenjiao Wu, Chao Wang, Changliang Xia, Shuwen Liu, Qinghua Mei
Summary: The study reveals the regulatory effect of let-7 on influenza A infection, wherein let-7 can modulate interferon expression and inhibit viral replication. Additionally, let-7 may serve as a potential biomarker of influenza A infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chien-Hsiu Li, Chiao-Chun Liao
Summary: Cancer is often the result of abnormal glucose uptake and imbalanced nutrient metabolism. Dysregulation of glucose metabolism and autophagy, as well as the involvement of miRNA Let-7, play crucial roles in tumor progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
Jun Liu, Madeline A. Sauer, Shaza G. Hussein, Junyu Yang, Daniel G. Tenen, Li Chai
Summary: SALL4, a transcription factor important in embryonic stem cells, is re-expressed in various human cancers and its dysregulation contributes to cancer pathogenesis and drug resistance. Recent studies suggest that miRNAs play a crucial role in controlling SALL4 expression, making them promising therapeutic targets for cancer treatment.
Article
Physiology
Ying Huang, Manshu Yu, Akihiro Kuma, Janet D. Klein, Yanhua Wang, Faten Hassounah, Hui Cai, Xiaonan H. Wang
Summary: This study found that Acu/LFES enhances protein synthesis in both hindlimb and forelimb muscles by reducing let-7-5p levels, which leads to upregulation of the Igf1 signaling pathway. This provides a new understanding of how electrical acupuncture treatment positively influences muscle health.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Shiyao Yang, Jing Gao, Meng Chen, Yuting Sun, Xin Qiao, Hongchen Mao, Li Guo, Yang Yu, Deqin Yang
Summary: This study identified the role of let-7a in the osteogenesis of BMMSCs and provided a potential method for periodontal bone regeneration. Let-7a was found to promote osteogenesis through the Fas/FasL-autophagy pathway, suggesting its promising application in periodontal bone regeneration.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tomohiro Inui, Hideki Sezutsu, Takaaki Daimon
Summary: The let-7 microRNA controls the timing of developmental programs and triggers the juvenile-adult transition in various organisms. In Bombyx mori, let-7 is required for the coordination of ecdysone and juvenile hormone biosynthesis during metamorphosis.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Jiahui Song, Haining Lv, Beibei Liu, Mingjun Hao, Hugh S. Taylor, Xuchen Zhang, Da Li, Yingqun Huang
Summary: The study reveals the important role of let-7 in liver fibrosis progression. It inhibits the production of TGF-I31 and expression of FAS, thereby reducing hepatocyte apoptosis and liver fibrosis. The findings highlight the potential use of let-7 and its derivatives as therapeutic agents for liver fibrosis.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Calder W. Reinsborough, Helene Ipas, Nathan S. Abell, Ellen B. Gouws, J. Paige Williams, Marvin Mercado, Carla Van den Berg, Blerta Xhemalce
Summary: BCDIN3D plays a crucial role in regulating metabolic pathways in cancer, with a connection to increased glycolysis and reduced glucose metabolism capacity, while also regulating ALDOC expression. This connection may be relevant to breast cancer, obesity, and T2D.
Article
Endocrinology & Metabolism
Maryam Daneshvar, Mansoureh Movahedin, Mohammad Salehi, Mehrdad Noruzinia
Summary: The study evaluated the impact of re-vitrification on the expression of miR-16, miR-let7a, and target genes in human blastocysts. The results showed that re-vitrification did not affect the ability of blastocysts to re-expand in culture, but led to a significant decrease in the expression of miR-16 and miR-let7a, along with a significant upregulation of the target genes ITG beta 3 and BCL-2 in re-vitrified and vitrified embryos.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Editorial Material
Parasitology
Bruno Douradinha
Summary: The pro-apoptotic action of peroxynitrite may contribute to the attenuated protection mediated by malarial sporozoite.
TRENDS IN PARASITOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Min Woo Kim, Jonathan Kipnis
Summary: This study demonstrates that opioid use affects the communication between the central nervous system and the peripheral immune system, leading to changes in T cell and cytokine modulation of brain function, and is associated with withdrawal-induced behavioral dysfunction.
Article
Oncology
Lili Yin, Yu Wang
Summary: The study revealed that NEAT1 promotes malignant phenotypes of ovarian cancer cells by regulating the let-7 g/MEST/ATGL signaling axis, highlighting its significance as a potential molecular target and biomarker for ovarian cancer.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Tian-Feng Duan, Shu-Jing Gao, Hai-Chao Wang, Ling Li, Yan-Yan Li, Yao Tan, Bao-Ping Pang
Summary: The study finds that let-7-5p plays an important role in the regulation of reproductive diapause and development in adult Galeruca daurica. By modulating the expression of Kruppel homolog 1 (Kr-h1), let-7-5p affects ovarian development, lipid accumulation, and fat body expansion.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiaolei Wang, Terrence Tsz-Tai Yuen, Ying Dou, Jingchu Hu, Renhao Li, Zheng Zeng, Xuansheng Lin, Huarui Gong, Celia Hoi-Ching Chan, Chaemin Yoon, Huiping Shuai, Deborah Tip-Yin Ho, Ivan Fan-Ngai Hung, Bao-Zhong Zhang, Hin Chu, Jian-Dong Huang
Summary: Researchers demonstrate the importance of cellular immunity in protecting against SARS-CoV-2 by showing that mice lacking B cells can still develop a robust immune response through vaccination or viral challenge. This study has important implications for understanding the impact of SARS-CoV-2 variants on the immune system.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Hailin Zou, Juan Luo, Yibo Guo, Yuhong Liu, Yun Wang, Liang Deng, Peng Li
Summary: This study reveals that the RNA binding protein LIN28 plays a role in modulating the cancer stem cell-like properties and tumor progression in triple negative breast cancer (TNBC) through the Hippo signaling pathway. LIN28 overexpression is correlated with poorer overall survival in TNBC patients. The study also highlights the LIN28/MSI2-YAP1 regulatory axis as a potential therapeutic strategy for TNBC with LIN28 overexpression.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)