An update of cyclooxygenase (COX)-inhibitors in epilepsy disorders

Anticonvulsant effects of acetaminophen in mice: Comparison with the effects of nonsteroidal anti-inflammatory drugs

(2018) Katsuya Suemaru et al.   EPILEPSY RESEARCH

Discovery of novel Methylsulfonyl phenyl derivatives as potent human Cyclooxygenase-2 inhibitors with effective anticonvulsant action: Design, synthesis, in-silico, in-vitro and in-vivo evaluation

(2018) Chandra Bhushan Mishra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy

(2018) Lin Zhou et al.   JOURNAL OF NEUROSCIENCE

Postictal hypoperfusion/hypoxia provides the foundation for a unified theory of seizure-induced brain abnormalities and behavioral dysfunction

(2017) Jordan S. Farrell et al.   EPILEPSIA

Neuroinflammatory targets and treatments for epilepsy validated in experimental models

(2017) Eleonora Aronica et al.   EPILEPSIA

Cyclooxygenase-2 inhibitors differentially attenuate pentylenetetrazol-induced seizures and increase of pro- and anti-inflammatory cytokine levels in the cerebral cortex and hippocampus of mice

(2017) Fernanda Rossatto Temp et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Excitotoxicity-induced prostaglandin D2production induces sustained microglial activation and delayed neuronal death

(2017) Kensuke Iwasa et al.   JOURNAL OF LIPID RESEARCH

Animal Models of Seizures and Epilepsy: Past, Present, and Future Role for the Discovery of Antiseizure Drugs

(2017) Wolfgang Löscher   NEUROCHEMICAL RESEARCH

Mossy Fiber Sprouting in the Epileptic Brain: Taking on the Lernaean Hydra

(2017) Steve Danzer   Epilepsy Currents

Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model

(2016) Vinícius Vieira et al.   EPILEPSY RESEARCH

Microglia-Neuron Communication in Epilepsy

(2016) Ukpong B. Eyo et al.   GLIA

Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to Bedside

(2016) Avijit Dey et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Postictal behavioural impairments are due to a severe prolonged hypoperfusion/hypoxia event that is COX-2 dependent

(2016) Jordan S Farrell et al.   eLife

Cyclooxygenase-1 as a Potential Therapeutic Target for Seizure Suppression: Evidences from Zebrafish Pentylenetetrazole-Seizure Model

(2016) Patrícia Gonçalves Barbalho et al.   Frontiers in Neurology

Hippocampal neuronal cyclooxygenase-2 downstream signaling imbalance in a rat model of chronic aluminium gluconate administration

(2015) Hong Wang et al.   Behavioral and Brain Functions

Antiepileptogenic effects of the selective COX-2 inhibitor etoricoxib, on the development of spontaneous absence seizures in WAG/Rij rats

(2015) Rita Citraro et al.   BRAIN RESEARCH BULLETIN

Anticonvulsant activity of the cyclooxygenase-2 (COX-2) inhibitor etoricoxib in pentylenetetrazole-kindled rats is associated with memory impairment

(2015) Jatinder Katyal et al.   EPILEPSY & BEHAVIOR

Therapeutic potential of cyclooxygenase-3 inhibitors in the management of glioblastoma

(2015) Ersoy Oksuz et al.   JOURNAL OF NEURO-ONCOLOGY

Animal models in epilepsy research: legacies and new directions

(2015) Brian P Grone et al.   NATURE NEUROSCIENCE

Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus

(2015) Jianxiong Jiang et al.   NEUROBIOLOGY OF DISEASE

A COX/5-LOX Inhibitor Licofelone Revealed Anticonvulsant Properties Through iNOS Diminution in Mice

(2015) Borna Payandemehr et al.   NEUROCHEMICAL RESEARCH

Lipopolysaccharide induced increase in seizure activity in two animal models of absence epilepsy WAG/Rij and GAERS rats and Long Evans rats

(2014) Zsolt Kovács et al.   BRAIN RESEARCH BULLETIN

Role of Inflammatory Mediators in the Pathogenesis of Epilepsy

(2014) Tadayuki Shimada et al.   MEDIATORS OF INFLAMMATION

The Potential of Antiseizure Drugs and Agents that Act on Novel Molecular Targets as Antiepileptogenic Treatments

(2014) Rafal M. Kaminski et al.   Neurotherapeutics

Epilepsy and Inflammation in the Brain: Overview and Pathophysiology

(2014) Annamaria Vezzani   Epilepsy Currents

Seizure susceptibility in immature brain due to lack of COX-2-induced PGF2α

(2013) Jee-In Chung et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain

(2013) Young Se Kwon et al.   Journal of Neuroinflammation

Tenidap, an agonist of the inwardly rectifying K+ channel Kir2·3, delays the onset of cortical epileptiform activity in a model of chronic temporal lobe epilepsy

(2013) Lan Xu et al.   NEUROLOGICAL RESEARCH

Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats

(2012) Lei Ma et al.   BRAIN RESEARCH

Stress and expression of cyclooxygenases (cox1, cox2a, cox2b) and intestinal eicosanoids, in Atlantic salmon, Salmo salar L.

(2011) R. E. Olsen et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

Up-regulation of major vault protein in the frontal cortex of patients with intractable frontal lobe epilepsy

(2011) Bei Liu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy

(2010) J Schlichtiger et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rethinking the role of cyclooxygenase-1 in neuroinflammation: More than homeostasis

(2010) Francesca Bosetti et al.   CELL CYCLE

Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy

(2010) Linda Holtman et al.   EPILEPSY RESEARCH

The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy

(2010) Nadine Polascheck et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective Effect of Visnagin on Kainic Acid-induced Neuronal Cell Death in the Mice Hippocampus

(2010) Min-Soo Kwon et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy

(2009) L. Holtman et al.   EPILEPSY RESEARCH

Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition

(2009) Guido Zibell et al.   NEUROPHARMACOLOGY

COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

(2009) Erwin A. van Vliet et al.   NEUROPHARMACOLOGY

Stage- and region-specific cyclooxygenase expression and effects of a selective COX-1 inhibitor in the mouse amygdala kindling model

(2009) Shinji Tanaka et al.   NEUROSCIENCE RESEARCH

A 6-week, multicentre, randomised, double-blind, double-dummy, active-controlled, clinical safety study of lumiracoxib and rofecoxib in osteoarthritis patients

(2008) Kirstin Stricker et al.   BMC MUSCULOSKELETAL DISORDERS

Cyclooxygenase in normal human tissues - is COX-1 really a constitutive isoform, and COX-2 an inducible isoform?

(2008) Nina Zidar et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Astrocytes in the Epileptic Brain

(2008) Jonathon Wetherington et al.   NEURON

T-type channel blocking properties and antiabsence activity of two imidazo[1,2-b]pyridazine derivatives structurally related to indomethacin

(2008) Maria Grazia Rimoli et al.   NEUROPHARMACOLOGY