The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics
出版年份 2014 全文链接
标题
The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics
作者
关键词
-
出版物
Frontiers in Oncology
Volume 4, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2014-07-24
DOI
10.3389/fonc.2014.00195
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The potential of heparanase as a therapeutic target in cancer
- (2014) Claudio Pisano et al. BIOCHEMICAL PHARMACOLOGY
- Heparanase expression and localization in different types of human lung cancer
- (2014) Teresa Cristina Fernandes dos Santos et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival
- (2014) Yunping Hu et al. CARCINOGENESIS
- Heparanase as a Target in Cancer Therapy
- (2014) Valentina Masola et al. CURRENT CANCER DRUG TARGETS
- Loss of HSulf-1 expression enhances tumorigenicity by inhibiting Bim expression in ovarian cancer
- (2014) Xiaoping He et al. INTERNATIONAL JOURNAL OF CANCER
- Heparan Sulfate Containing Unsubstituted Glucosamine Residues
- (2014) Satomi Nadanaka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ovarian Cancer Cell Heparan Sulfate 6-O-Sulfotransferases Regulate an Angiogenic Program Induced by Heparin-binding Epidermal Growth Factor (EGF)-like Growth Factor/EGF Receptor Signaling
- (2014) Claire L. Cole et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TGF-β1 and FGF2 Stimulate the Epithelial-Mesenchymal Transition of HERS Cells Through a MEK-Dependent Mechanism
- (2014) Jie Chen et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Expression of heparanase in soft tissue sarcomas of adults
- (2014) Olga Kazarin et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Synthesis and Biological Evaluation of a Unique Heparin Mimetic Hexasaccharide for Structure–Activity Relationship Studies
- (2014) Sucharita Roy et al. JOURNAL OF MEDICINAL CHEMISTRY
- Heparanase enhances myeloma progression via CXCL10 downregulation
- (2014) U Barash et al. LEUKEMIA
- Glucose-regulated protein 78 and heparanase expression in oral squamous cell carcinoma: correlations and prognostic significance
- (2014) Fei Xia et al. World Journal of Surgical Oncology
- Syndecans as Modulators and Potential Pharmacological Targets in Cancer Progression
- (2014) Despoina Barbouri et al. Frontiers in Oncology
- Post-Synthetic Regulation of HS Structure: The Yin and Yang of the Sulfs in Cancer
- (2014) Romain R. Vivès et al. Frontiers in Oncology
- Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies
- (2013) Michel Record et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D
- (2013) K. W. Tan et al. BLOOD
- Specific genes involved in synthesis and editing of heparan sulfate proteoglycans show altered expression patterns in breast cancer
- (2013) Iván Fernández-Vega et al. BMC CANCER
- Heparanase inhibits osteoblastogenesis and shifts bone marrow progenitor cell fate in myeloma bone disease
- (2013) Jian Ruan et al. BONE
- MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways
- (2013) Longlong Bao et al. CANCER LETTERS
- Identification of integrin α3 as a molecular marker of cells undergoing epithelial-mesenchymal transition and of cancer cells with aggressive phenotypes
- (2013) Takuya Shirakihara et al. CANCER SCIENCE
- Matrix detachment and proteasomal inhibitors diminish Sulf-2 expression in breast cancer cell lines and mouse xenografts
- (2013) Ashwani Khurana et al. CLINICAL & EXPERIMENTAL METASTASIS
- The expression and clinical significance of microRNA-1258 and heparanase in human breast cancer
- (2013) Dabei Tang et al. CLINICAL BIOCHEMISTRY
- The heparanase/syndecan-1 axis in cancer: mechanisms and therapies
- (2013) Vishnu C. Ramani et al. FEBS Journal
- Enhanced stromal syndecan-1 expression is an independent risk factor for poor survival in bladder cancer
- (2013) Tibor Szarvas et al. HUMAN PATHOLOGY
- Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase
- (2013) YANG LI et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Activation of the Transcription Factor GLI1 by WNT Signaling Underlies the Role of SULFATASE 2 as a Regulator of Tissue Regeneration
- (2013) Ikuo Nakamura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes
- (2013) Camilla A. Thompson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Heparanase expression correlates with poor survival in oral mucosal melanoma
- (2013) Xin Wang et al. MEDICAL ONCOLOGY
- Heparanase overexpression participates in tumor growth of cervical cancer in vitro and in vivo
- (2013) Chao Zeng et al. MEDICAL ONCOLOGY
- Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors
- (2013) K E Hunter et al. ONCOGENE
- EGFR, FLT1 and Heparanase as Markers Identifying Patients at Risk of Short Survival in Cholangiocarcinoma
- (2013) Andreas-Claudius Hoffmann et al. PLoS One
- Heparan Sulfate and Heparanase as Modulators of Breast Cancer Progression
- (2013) Angélica M. Gomes et al. Biomed Research International
- Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues
- (2013) Edward Hammond et al. FEBS Open Bio
- The Role of Syndecan-1 in Cellular Signaling and its Effects on Heparan Sulfate Biosynthesis in Mesenchymal Tumors
- (2013) Tünde Szatmári et al. Frontiers in Oncology
- Endo-sulfatase Sulf-1 Protein Expression is Down-regulated in Gastric Cancer
- (2012) Gopisetty Gopal et al. Asian Pacific Journal of Cancer Prevention
- Abstract 558: Targeting tumour heparanase activity using fully human monoclonal antibodies
- (2012) Palaniswami Rathanaswami et al. CANCER RESEARCH
- The human sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone (OKN-007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1 signaling
- (2012) Xin Zheng et al. GENES CHROMOSOMES & CANCER
- Human sulfatase-1 inhibits the migration and proliferation of SMMC-7721 hepatocellular carcinoma cells by downregulating the growth factor signaling
- (2012) Hu Liu et al. HEPATOLOGY RESEARCH
- The enhanced antitumor effects of biodegradable cationic heparin-polyethyleneimine nanogels delivering HSulf-1 gene combined with cisplatin on ovarian cancer
- (2012) PING LIU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Deciphering Mode of Action of Heparanase Using Structurally Defined Oligosaccharides
- (2012) Sherket Peterson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma
- (2012) Joanna J. Phillips et al. JOURNAL OF CLINICAL INVESTIGATION
- Up-regulated expression of sulfatases (SULF1 and SULF2) as prognostic and metastasis predictive markers in human gastric cancer
- (2012) Keun Hur et al. JOURNAL OF PATHOLOGY
- A new mechanism of action of sulodexide in diabetic nephropathy: inhibits heparanase-1 and prevents FGF-2-induced renal epithelial-mesenchymal transition
- (2012) Valentina Masola et al. Journal of Translational Medicine
- Heparanase-Induced GEF-H1 Signaling Regulates the Cytoskeletal Dynamics of Brain Metastatic Breast Cancer Cells
- (2012) Lon D. Ridgway et al. MOLECULAR CANCER RESEARCH
- PG545, a Heparan Sulfate Mimetic, Reduces Heparanase Expression In Vivo, Blocks Spontaneous Metastases and Enhances Overall Survival in the 4T1 Breast Carcinoma Model
- (2012) Edward Hammond et al. PLoS One
- The expression of heparanase and microRNA-1258 in human non-small cell lung cancer
- (2012) Hongcheng Liu et al. TUMOR BIOLOGY
- SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study
- (2012) Natalie Shaubie Lui et al. BMJ Open
- Molecular model of human heparanase with proposed binding mode of a heparan sulfate oligosaccharide and catalytic amino acids
- (2011) Nicolas Sapay et al. BIOPOLYMERS
- PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models
- (2011) K Dredge et al. BRITISH JOURNAL OF CANCER
- Abstract 5459: Antitumor activity of EP80061, a small-glyco drug in preclinical studies
- (2011) Vanessa Nancy-Portebois et al. CANCER RESEARCH
- HSulf-1 Modulates FGF2- and Hypoxia-Mediated Migration and Invasion of Breast Cancer Cells
- (2011) A. Khurana et al. CANCER RESEARCH
- HSulf-1 inhibits cell proliferation and invasion in human gastric cancer
- (2011) Jie Li et al. CANCER SCIENCE
- SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis
- (2011) Joseph P. Ritchie et al. CLINICAL CANCER RESEARCH
- Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-d-glucuronidase (heparanase)
- (2011) Neha S Gandhi et al. GLYCOBIOLOGY
- Heparanase expression in head and neck squamous cell carcinomas is associated with reduced proliferation and improved survival
- (2011) Carolin Mogler et al. HISTOPATHOLOGY
- Heparanase and Syndecan-1 Interplay Orchestrates Fibroblast Growth Factor-2-induced Epithelial-Mesenchymal Transition in Renal Tubular Cells
- (2011) Valentina Masola et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor
- (2011) Soo-Hyun Kim et al. JOURNAL OF ENDOCRINOLOGY
- SULFs in human neoplasia: implication as progression and prognosis factors
- (2011) Caroline Bret et al. Journal of Translational Medicine
- Hypoxia negatively regulates heparan sulfatase 2 expression in renal cancer cell lines
- (2011) Ashwani Khurana et al. MOLECULAR CARCINOGENESIS
- M402, a Novel Heparan Sulfate Mimetic, Targets Multiple Pathways Implicated in Tumor Progression and Metastasis
- (2011) He Zhou et al. PLoS One
- HSulf-1 suppresses cell growth and down-regulates Hedgehog signaling in human gastric cancer cells
- (2011) HUI-YAN MA et al. Oncology Letters
- Relationship Between Serum Heparanase and Microscopic Venous Invasion in Patients With Hepatocellular Carcinoma
- (2010) Gui-Bo Wang et al. AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- Expression of SATB1 and heparanase in gastric cancer and its relationship to clinicopathologic features
- (2010) CHAO CHENG et al. APMIS
- Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis
- (2010) A. Purushothaman et al. BLOOD
- Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate
- (2010) Steven D Rosen et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: Associated signaling pathways, tumor phenotypes, and survival
- (2010) Ju Dong Yang et al. GENES CHROMOSOMES & CANCER
- The oncogenic effect of sulfatase 2 in human hepatocellular carcinoma is mediated in part by glypican 3-dependent Wnt activation
- (2010) Jin-Ping Lai et al. HEPATOLOGY
- Preferential up-regulation of heparanase and cyclooxygenase-2 in carcinogenesis of Barrett’s oesophagus and intestinal-type gastric carcinoma
- (2010) Ryotaro Sonoda et al. HISTOPATHOLOGY
- Pre-clinical and clinical significance of heparanase in Ewing’s sarcoma
- (2010) Itay Shafat et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Sulfatase 2 protects hepatocellular carcinoma cells against apoptosis induced by the PI3K inhibitor LY294002 and ERK and JNK kinase inhibitors
- (2010) Jin-Ping Lai et al. LIVER INTERNATIONAL
- Abnormal expression of early growth response 1 in gastric cancer: Association with tumor invasion, metastasis and heparanase transcription
- (2010) Liduan Zheng et al. PATHOLOGY INTERNATIONAL
- Marine-derived oligosaccharide sulfate (JG3) suppresses heparanase-driven cell adhesion events in heparanase over-expressing CHO-K1 cells
- (2009) Qiu-ning Li et al. ACTA PHARMACOLOGICA SINICA
- Proteolytic cleavage of the rat heparan sulfate 6-O-endosulfatase SulfFP2 by furin-type proprotein convertases
- (2009) Satoshi Nagamine et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Regulation of HSulf-1 Expression by Variant Hepatic Nuclear Factor 1 in Ovarian Cancer
- (2009) P. Liu et al. CANCER RESEARCH
- A novel SULF1 splice variant inhibits Wnt signalling but enhances angiogenesis by opposing SULF1 activity
- (2009) Amrit Paul Sahota et al. EXPERIMENTAL CELL RESEARCH
- Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88
- (2009) Md Motarab Hossain et al. GLYCOBIOLOGY
- The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy
- (2009) K. Dredge et al. INVESTIGATIONAL NEW DRUGS
- Functional Consequences of the Subdomain Organization of the Sulfs
- (2009) Renhong Tang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis
- (2009) H Lemjabbar-Alaoui et al. ONCOGENE
- Hypoxia activates heparanase expression in an NF-κB dependent manner
- (2009) Wu ONCOLOGY REPORTS
- PI-88: a novel inhibitor of angiogenesis
- (2008) Ragini Kudchadkar et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma
- (2008) Jin-Ping Lai et al. HEPATOLOGY
- Cathepsin L Is Responsible for Processing and Activation of Proheparanase through Multiple Cleavages of a Linker Segment
- (2008) Ghada Abboud-Jarrous et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Heparanase Stimulation of Protease Expression Implicates It as a Master Regulator of the Aggressive Tumor Phenotype in Myeloma
- (2008) Anurag Purushothaman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression of Heparanase in Hepatocellular Carcinoma Has Prognostic Significance: A Tissue Microarray Study
- (2008) Gang Chen et al. ONCOLOGY RESEARCH
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