Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma

SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans

(2011) Kun-Wei Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

A multigene predictor of outcome in glioblastoma

(2011) H. Colman et al.   NEURO-ONCOLOGY

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate

(2010) Steven D Rosen et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas

(2010) T. Ozawa et al.   GENES & DEVELOPMENT

Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche

(2010) Aliete Langsdorf et al.   GLYCOBIOLOGY

Heparan Sulfate Regulates VEGF165- and VEGF121-mediated Vascular Hyperpermeability

(2010) Ding Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth

(2010) Ken D. Johnstone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

(2010) K. Salaita et al.   SCIENCE

Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer

(2009) M. Khasraw et al.   ANNALS OF ONCOLOGY

Identification of SULF2 as a Novel Transcriptional Target of p53 by Use of Integrated Genomic Analyses

(2009) B. Nelson Chau et al.   CANCER RESEARCH

Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88

(2009) Md Motarab Hossain et al.   GLYCOBIOLOGY

HpSulf, a heparan sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during sea urchin development

(2009) Kazumasa Fujita et al.   MECHANISMS OF DEVELOPMENT

Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis

(2009) H Lemjabbar-Alaoui et al.   ONCOGENE

Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic Alterations

(2009) Cameron Brennan et al.   PLoS One

PDGF-A interactions with fibronectin reveal a critical role for heparan sulfate in directed cell migration during Xenopus gastrulation

(2009) E. M. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Downregulation of Wnt2 and β-catenin by siRNA suppresses malignant glioma cell growth

(2008) P Pu et al.   CANCER GENE THERAPY

Lentiviral Transduction of Mammary Stem Cells for Analysis of Gene Function during Development and Cancer

(2008) Bryan E. Welm et al.   Cell Stem Cell

Extracellular regulation of developmental cell signaling by XtSulf1

(2008) Stephen D. Freeman et al.   DEVELOPMENTAL BIOLOGY

Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma

(2008) Jin-Ping Lai et al.   HEPATOLOGY

Sulf Loss InfluencesN-, 2-O-, and 6-O-Sulfation of Multiple Heparan Sulfate Proteoglycans and Modulates Fibroblast Growth Factor Signaling

(2008) William C. Lamanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential involvement of the extracellular 6-O-endosulfatases Sulf1 and Sulf2 in brain development and neuronal and behavioural plasticity

(2008) Ina Kalus et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE