Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches
出版年份 2018 全文链接
标题
Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches
作者
关键词
-
出版物
Frontiers in Endocrinology
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2018-08-24
DOI
10.3389/fendo.2018.00485
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation
- (2018) Samar H Ibrahim et al. GUT
- Targeting incretin hormones and the ASK-1 pathway as therapeutic options in the treatment of non-alcoholic steatohepatitis
- (2018) Alexander J. Kovalic et al. Hepatology International
- Lipotoxicity and the gut-liver axis in NASH pathogenesis
- (2018) Fabio Marra et al. JOURNAL OF HEPATOLOGY
- Pharmacotherapy for NASH: Current and emerging
- (2018) Monica A. Konerman et al. JOURNAL OF HEPATOLOGY
- Genetics and epigenetics of NAFLD and NASH: Clinical impact
- (2018) Mohammed Eslam et al. JOURNAL OF HEPATOLOGY
- Preclinical models of non-alcoholic fatty liver disease
- (2018) Prasanna K. Santhekadur et al. JOURNAL OF HEPATOLOGY
- NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
- (2018) Stephen A Harrison et al. LANCET
- Gut hormone polyagonists for the treatment of type 2 diabetes
- (2018) Sara J. Brandt et al. PEPTIDES
- Reduced oxidative capacity in macrophages results in systemic insulin resistance
- (2018) Saet-Byel Jung et al. Nature Communications
- Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice
- (2018) Kook Hwan Kim et al. Scientific Reports
- Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice
- (2017) Mitchell Bijnen et al. GUT
- Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration
- (2017) Gloria Alvarez-Sola et al. GUT
- Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal
- (2017) Naoki Ikenaga et al. GUT
- A novel glucagon-like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice
- (2017) M. Pilar Valdecantos et al. HEPATOLOGY
- Efficacy and safety of simtuzumab for the treatment of nonalcoholic steatohepatitis with bridging fibrosis or cirrhosis: results of two phase 2b, dose-ranging, randomized, placebo-controlled trials
- (2017) A. Sanyal et al. JOURNAL OF HEPATOLOGY
- BMS-986036 (pegylated FGF21) in patients with non-alcoholic steatohepatitis: a phase 2 study
- (2017) A. Sanyal et al. JOURNAL OF HEPATOLOGY
- Targeting the gut-liver axis in liver disease
- (2017) Reiner Wiest et al. JOURNAL OF HEPATOLOGY
- NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
- (2017) Auvro R. Mridha et al. JOURNAL OF HEPATOLOGY
- Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH
- (2017) George N. Ioannou et al. JOURNAL OF LIPID RESEARCH
- Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease
- (2017) Bo Kyung Koo et al. LIVER INTERNATIONAL
- Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
- (2017) Jer-Yuan Hsu et al. NATURE
- Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice
- (2017) Bérengère Benoit et al. NATURE MEDICINE
- Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis
- (2017) Cen Xie et al. NATURE MEDICINE
- Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates
- (2017) Pi-Xiao Wang et al. NATURE MEDICINE
- GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
- (2017) Linda Yang et al. NATURE MEDICINE
- GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
- (2017) Shannon E Mullican et al. NATURE MEDICINE
- The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
- (2017) Paul J Emmerson et al. NATURE MEDICINE
- Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling
- (2017) Daniel A Giles et al. NATURE MEDICINE
- The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis
- (2017) Peng Zhang et al. NATURE MEDICINE
- NASH: Novel therapeutic strategies targeting ASK1 in NASH
- (2017) Susanne Schuster et al. Nature Reviews Gastroenterology & Hepatology
- Mechanisms of hepatic stellate cell activation
- (2017) Takuma Tsuchida et al. Nature Reviews Gastroenterology & Hepatology
- Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
- (2017) Zobair Younossi et al. Nature Reviews Gastroenterology & Hepatology
- The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis
- (2017) J.D. Schumacher et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial
- (2017) Tisha R Joy et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Alterations in Gut Microbiota and Immunity by Dietary Fat
- (2017) Bo-Gie Yang et al. YONSEI MEDICAL JOURNAL
- Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex
- (2017) So Yeon Kim et al. Nature Communications
- Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients
- (2017) Franck Chiappini et al. Scientific Reports
- Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice
- (2017) Sigrid Jall et al. Molecular Metabolism
- Obesogenic diet-induced gut barrier dysfunction and pathobiont expansion aggravate experimental colitis
- (2017) June-Chul Lee et al. PLoS One
- Metabolomic characteristics of cholesterol-induced non-obese nonalcoholic fatty liver disease in mice
- (2017) Lan N. Tu et al. Scientific Reports
- GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury
- (2017) Hyo Kyun Chung et al. Scientific Reports
- Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes
- (2016) Petra Hirsova et al. GASTROENTEROLOGY
- Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders
- (2016) Yasunori Fujita et al. Geriatrics & Gerontology International
- Lipotoxicity pathways intersect in hepatocytes: Endoplasmic reticulum stress, c-Jun N-terminal kinase-1, and death receptors
- (2016) Yuko Akazawa et al. HEPATOLOGY RESEARCH
- Short Term Palmitate Supply Impairs Intestinal Insulin Signaling via Ceramide Production
- (2016) Thi Thu Trang Tran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis
- (2016) Hyo Kyun Chung et al. JOURNAL OF CELL BIOLOGY
- DKK3 expression in hepatocytes defines susceptibility to liver steatosis and obesity
- (2016) Lanfeng Xie et al. JOURNAL OF HEPATOLOGY
- Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis
- (2016) Matthew J. Armstrong et al. JOURNAL OF HEPATOLOGY
- Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial
- (2016) Jeffrey Cui et al. JOURNAL OF HEPATOLOGY
- Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis
- (2016) Petra Hirsova et al. JOURNAL OF LIPID RESEARCH
- Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances
- (2016) Jennie Ka Ching Lau et al. JOURNAL OF PATHOLOGY
- Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study
- (2016) Matthew James Armstrong et al. LANCET
- Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease
- (2016) Manoela Mota et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
- (2016) Giovanni Musso et al. NATURE REVIEWS DRUG DISCOVERY
- Endoplasmic reticulum proteostasis in hepatic steatosis
- (2016) Andrei Baiceanu et al. Nature Reviews Endocrinology
- Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways
- (2016) Pengfei Xu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells
- (2016) Nancy Magee et al. Biomed Research International
- Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice
- (2015) Xiaomeng Liu et al. ENDOCRINOLOGY
- Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity
- (2015) Silvia Sookoian et al. HEPATOLOGY
- Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes
- (2015) Samar H. Ibrahim et al. HEPATOLOGY
- Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance
- (2015) Pär Steneberg et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner
- (2015) Eiji Kakazu et al. JOURNAL OF LIPID RESEARCH
- FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis
- (2015) Rachel J. Perry et al. Nature Communications
- GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective
- (2015) Ramu Adela et al. Journal of Diabetes Research
- Nonalcoholic fatty liver disease
- (2015) Elizabeth M. Brunt et al. Nature Reviews Disease Primers
- Sitagliptin attenuates methionine/choline-deficient diet-induced steatohepatitis
- (2014) Yun-A. Jung et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress
- (2014) Seong Hun Kim et al. DIABETOLOGIA
- Fibroblast Growth Factor 21 Limits Lipotoxicity by Promoting Hepatic Fatty Acid Activation in Mice on Methionine and Choline-Deficient Diets
- (2014) Ffolliott M. Fisher et al. GASTROENTEROLOGY
- Roles for Chemokines in Liver Disease
- (2014) Fabio Marra et al. GASTROENTEROLOGY
- Fattyaciddesaturase 1gene polymorphisms control human hepatic lipid composition
- (2014) Libo Wang et al. HEPATOLOGY
- Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
- (2014) Changtao Jiang et al. JOURNAL OF CLINICAL INVESTIGATION
- NLRP3 inflammasome activation is required for fibrosis development in NAFLD
- (2014) Alexander Wree et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
- (2014) Brian Finan et al. NATURE MEDICINE
- Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease
- (2014) Xue-Qun Zhang WORLD JOURNAL OF GASTROENTEROLOGY
- Propranolol, a β-adrenoceptor antagonist, worsens liver injury in a model of non-alcoholic steatohepatitis
- (2013) Chad McKee et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Brown adipose tissue transplantation improves whole-body energy metabolism
- (2013) Xiaomeng Liu et al. CELL RESEARCH
- Microbiota-liver axis in hepatic disease
- (2013) Benoit Chassaing et al. HEPATOLOGY
- Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice
- (2013) Jean-Philippe Pradere et al. HEPATOLOGY
- NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice
- (2013) Alexander Wree et al. HEPATOLOGY
- Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis
- (2013) A. Wehr et al. JOURNAL OF IMMUNOLOGY
- NAG-1/GDF15 Transgenic Mouse Has Less White Adipose Tissue and a Reduced Inflammatory Response
- (2013) J. M. Kim et al. MEDIATORS OF INFLAMMATION
- Linagliptin alleviates hepatic steatosis and inflammation in a mouse model of non-alcoholic steatohepatitis
- (2013) Thomas Klein et al. Medical Molecular Morphology
- Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
- (2013) Quentin M. Anstee et al. Nature Reviews Gastroenterology & Hepatology
- From NAFLD to NASH to cirrhosis—new insights into disease mechanisms
- (2013) Alexander Wree et al. Nature Reviews Gastroenterology & Hepatology
- NAFLD, NASH and liver cancer
- (2013) Gregory A. Michelotti et al. Nature Reviews Gastroenterology & Hepatology
- Acute Exercise Induces FGF21 Expression in Mice and in Healthy Humans
- (2013) Kook Hwan Kim et al. PLoS One
- Association between Serum Atypical Fibroblast Growth Factors 21 and 19 and Pediatric Nonalcoholic Fatty Liver Disease
- (2013) Anna Alisi et al. PLoS One
- Pro-Inflammatory Activated Kupffer Cells by Lipids Induce Hepatic NKT Cells Deficiency through Activation-Induced Cell Death
- (2013) Tongfang Tang et al. PLoS One
- Lipid-Induced Toxicity Stimulates Hepatocytes to Release Angiogenic Microparticles That Require Vanin-1 for Uptake by Endothelial Cells
- (2013) D. Povero et al. Science Signaling
- Glucagon-like peptide-1 receptor agonism improves metabolic, biochemical, and histopathological indices of nonalcoholic steatohepatitis in mice
- (2012) James L. Trevaskis et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2
- (2012) Kouichi Miura et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Endoplasmic Reticulum Stress in Nonalcoholic Fatty Liver Disease
- (2012) Michael J. Pagliassotti Annual Review of Nutrition
- Direct Control of Brown Adipose Tissue Thermogenesis by Central Nervous System Glucagon-Like Peptide-1 Receptor Signaling
- (2012) S. H. Lockie et al. DIABETES
- FGF21 regulates PGC-1 and browning of white adipose tissues in adaptive thermogenesis
- (2012) f. M. Fisher et al. GENES & DEVELOPMENT
- GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus
- (2012) Juris J. Meier Nature Reviews Endocrinology
- Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis
- (2011) Keisuke Kakisaka et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents
- (2011) Joel E. Lavine JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice
- (2011) Yehuda Kamari et al. JOURNAL OF HEPATOLOGY
- FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
- (2011) S. Kir et al. SCIENCE
- The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance
- (2010) Tim C. M. A. Schreuder et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease
- (2010) Jody Dushay et al. GASTROENTEROLOGY
- Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
- (2010) Herbert Tilg et al. HEPATOLOGY
- Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment
- (2010) Vivian Barry-Hamilton et al. NATURE MEDICINE
- Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice
- (2009) A. Pocai et al. DIABETES
- Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells
- (2009) Yuren Wei et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
- (2008) J. Xu et al. DIABETES
- The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity
- (2008) ZhengZheng Li et al. HEPATOLOGY
- Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
- (2008) Catherine Postic et al. JOURNAL OF CLINICAL INVESTIGATION
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
- (2008) Stefano Romeo et al. NATURE GENETICS
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