Article
Biochemistry & Molecular Biology
Bo Qiao, Jing Liu, Na Deng, Ying Cai, Yao Bian, Yueying Wu, Zhoujin Tan
Summary: Fatigue and a high-fat diet disrupt the gut microbiota and lead to gastrointestinal disorders.
Article
Immunology
Kyoko Yamazaki, Tamotsu Kato, Yuuri Tsuboi, Eiji Miyauchi, Wataru Suda, Keisuke Sato, Mayuka Nakajima, Mai Yokoji-Takeuchi, Miki Yamada-Hara, Takahiro Tsuzuno, Aoi Matsugishi, Naoki Takahashi, Koichi Tabeta, Nobuaki Miura, Shujiro Okuda, Jun Kikuchi, Hiroshi Ohno, Kazuhisa Yamazaki
Summary: The study reveals that periodontal bacteria entering the gut can exacerbate the pathology of nonalcoholic fatty liver disease, resulting in worsened NAFLD pathology and liver fibrosis in a mouse model. The two periodontopathic bacteria induced distinct gene expression profiles, possibly due to differences in the quantity and quality of bacterial products entering the gut.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Seung Eun Park, Dongeun Lee, Jae Woong Jeong, Su-Hyung Lee, Seung Ju Park, Jaeseung Ryu, Se Kyu Oh, Hanseul Yang, Sungsoon Fang, Seyun Kim
Summary: This study reveals that intestinal epithelial IPMK is a critical regulator of colonic integrity and tissue regeneration by affecting tuft cell homeostasis and cholinergic output.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Nutrition & Dietetics
Xinxin Ren, Jia Xu, Ye Xu, Qin Wang, Kunlun Huang, Xiaoyun He
Summary: This study investigates the potential mechanism of Artemether (ART) in diet-induced intestinal injury. The results suggest that ART intervention may alleviate intestinal barrier function disorders and inflammatory responses by restoring intestinal flora balance, increasing the expression of tight junction proteins, and decreasing the expression of pro-inflammatory factors. Moreover, ART intervention inhibits the activation of the TLR4/NF-kappa B p65 pathway in colon tissue, indicating a potential protective effect of ART on intestinal inflammation.
Article
Chemistry, Applied
Tao Wang, Shuxuan Wang, Shuchen Dong, Yu Zhang, Mohamedelfatieh Ismael, Shuang Wang, Caihong Shi, Jie Yang, Xin Wang, Xin Lue
Summary: The study found that CCDB can alleviate colitis by strengthening the gut barrier, reducing oxidative stress and inflammation, and regulating the composition of gut microbiota.
Article
Microbiology
Lingyan Ma, Qicheng Shen, Wentao Lyu, Lu Lv, Wen Wang, Minjie Yu, Hua Yang, Shiyu Tao, Yingping Xiao
Summary: This study demonstrated that C. butyricum has a protective effect against colitis by modulating the gut microbiota and producing beneficial metabolites. Additionally, C. butyricum-derived extracellular vesicles show a positive impact on alleviating colitis.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Jiuxi Liu, Jiapei Cai, Peng Fan, Xue Dong, Naisheng Zhang, Jiandong Tai, Yongguo Cao
Summary: Salidroside, a glycoside extracted from Rhodiola rosea L., was found to ameliorate dextran sulfate sodium (DSS)-induced colitis by modulating the gut microbiota. Salidroside treatment inhibited colitis symptoms in mice, including colon length, histology, disease activity index (DAI) score, and macrophage levels in the intestine. In a fecal microbiota transplantation (FMT) study, fecal samples from Salidroside-treated mice significantly alleviated colitis symptoms in recipient mice, indicating the importance of gut microbiota in the therapeutic effect. Salidroside and FMT both influenced the structure and abundance of the gut microbiota, with decreased relative abundance of Turicibacter, Alistipes, Romboutsia, and increased relative abundance of Lactobacillus. The anti-inflammatory effect of Salidroside was dependent on the presence of gut microbiota, as evidenced by its disappearance in antibiotic-treated mice. Salidroside could be a promising functional food for colitis treatment.
Article
Gastroenterology & Hepatology
Pajau Vangay, Tonya Ward, Sarah Lucas, Lalit K. Beura, Dominique Sabas, Max Abramson, Lisa Till, Susan L. Hoops, Purna Kashyap, Ryan C. Hunter, David Masopust, Dan Knights
Summary: In this study, the differential effects of human gut microbiota from the United States and rural Thailand on the murine gut mucosa and immune system were assessed. The results suggest that Western-associated human gut microbes contribute to a pro-inflammatory immune response.
Article
Biochemistry & Molecular Biology
Ying Lan, Lili Chang, Jing Peng, Mengqi Zhang, Qingyang Sun, Ruixue Qiao, Xinglin Hou, Xuechao Ding, Qiang Zhang, Qiang Peng, Juane Dong, Xuebo Liu, Zhiyuan Ma
Summary: Currently, there is no definitive treatment for neurodegenerative diseases without side effects. Therefore, exploring the potential of natural polysaccharides in preventing cognitive dysfunctions is significant. This study found that sea buckthorn polysaccharide effectively alleviated high-fat diet-induced cognitive dysfunctions in mice through inhibition of neuroinflammation and amelioration of synaptic dysfunction. In addition, it improved gut barrier impairment and inflammatory responses by regulating the gut microbiome structure.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Immunology
Huixiang Yao, Yan Shi, Junqing Yuan, Ri Sa, Wei Chen, Xinjian Wan
Summary: This study demonstrated that matrine attenuated DSS-induced colitis by improving gut barrier integrity, inhibiting the PPAR-alpha signaling pathway, and modulating gut microbiota. These findings suggest that matrine may serve as a therapeutic agent for treating ulcerative colitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Baoming Tian, Jianhua Zhao, Min Zhang, Zhifei Chen, Qingyu Ma, Huicui Liu, Chenxi Nie, Ziqi Zhang, Wei An, Juxiu Li
Summary: The study suggests that anthocyanins from Lycium ruthenicum (ACs) can reduce weight gain, increase SCFA-producing bacteria, decrease endotoxin-producing bacteria, and lower endotoxin levels by modulating the gut microbiota. This leads to alleviation of colonic barrier dysfunction and inflammation induced by a high-fat diet.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yuanlong Hou, Wei Wei, Xiaojing Guan, Yali Liu, Gaorui Bian, Dandan He, Qilin Fan, Xiaoying Cai, Youying Zhang, Guangji Wang, Xiao Zheng, Haiping Hao
Summary: The study shows that dietary raffinose metabolism to fructose couples stress-induced gut microbial remodeling to intestinal stem cell renewal and epithelial homeostasis. Dietary impact on stress and gut microbial structure and epithelial integrity could be exploited to alleviate gut disorders. Dietary modulation of microbial metabolism shapes intestinal stem cell turnover, highlighting the interplay between diet, stress, and gut health.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Penghao Sun, Mengli Wang, Zhuoni Li, Jingjing Wei, Feng Liu, Wei Zheng, Xiaoyan Zhu, Xuejun Chai, Shanting Zhao
Summary: This study investigates the effects of an obesogenic diet on adolescents and explores the role of Eucommiae cortex polysaccharides in mitigating the diet-induced behavioral dysfunction. The study reveals that the supplementation of polysaccharides improves cognitive and social behavior by modulating gut microbiota and tryptophan metabolism in adolescent mice fed with the obesogenic diet.
Article
Cell Biology
Louise Dupraz, Aurelie Magniez, Nathalie Rolhion, Mathias L. Richard, Gregory Da Costa, Sothea Touch, Camille Mayeur, Julien Planchais, Allison Agus, Camille Danne, Chloe Michaudel, Madeleine Spatz, Francois Trottein, Philippe Langella, Harry Sokol, Marie-Laure Michel
Summary: The gut microbiota represses IL-17 production by gamma delta T cells through the production of metabolites, particularly propionate.
Article
Gastroenterology & Hepatology
Lina Fan, Yadong Qi, Siwen Qu, Xueqin Chen, Aiqing Li, Maher Hendi, Chaochao Xu, Lan Wang, Tongyao Hou, Jianmin Si, Shujie Chen
Summary: Inflammatory bowel disease (IBD) is an immune dysregulation disease with poor prognosis, and therapies based on gut microbe modulation have been proposed. The study showed that B. adolescentis has therapeutic effects on IBD, improving inflammation symptoms and promoting gut microbiota balance.
Article
Microbiology
Euon Jung Tak, Hyun Sik Kim, June-Young Lee, Woorim Kang, Dong-Wook Hyun, Pil Soo Kim, Na-Ri Shin, Jin-Woo Bae
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2017)
Article
Microbiology
Ji-Hyun Yun, Seong-Kyu Park, June-Young Lee, Mi-Ja Jung, Jin-Woo Bae
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2017)
Article
Microbiology
Ji-Hyun Yun, June-Young Lee, Dong-Wook Hyun, Mi-Ja Jung, Jin-Woo Bae
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2017)
Article
Microbiology
June-Young Lee, Pil Soo Kim, Dong-Wook Hyun, Hyun Sik Kim, Na-Ri Shin, Mi-Ja Jung, Ji-Hyun Yun, Min-Soo Kim, Tae Woong Whon, Jin-Woo Bae
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2017)
Article
Multidisciplinary Sciences
Hyejin Lim, Yu-Mi Lim, Kook Hwan Kim, Young Eui Jeon, Kihyoun Park, Jinyoung Kim, Hui-Yun Hwang, Dong Jin Lee, Haushabhau Pagire, Ho Jeong Kwon, Jin Hee Ahn, Myung-Shik Lee
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Ji-Hyun Yun, Mi-Ja Jung, Pil Soo Kim, Jin-Woo Bae
SCIENTIFIC REPORTS
(2018)
Review
Endocrinology & Metabolism
Yong-ho Lee, Jinyoung Kim, Kihyoun Park, Myung-Shik Lee
MOLECULAR METABOLISM
(2019)
Article
Multidisciplinary Sciences
Jinyoung Kim, Kihyoun Park, Min Jung Kim, Hyejin Lim, Kook Hwan Kim, Sun-Woo Kim, Eun-Seo Lee, Hyongbum (Henry) Kim, Sung Joo Kim, Kyu Yeon Hur, Jae Hyeon Kim, Jin Hee Ahn, Kun-Ho Yoon, Ji-Won Kim, Myung-Shik Lee
Summary: The study demonstrates that the autophagy enhancer MSL-7 reduces the accumulation of human IAPP oligomers and diminishes oligomer-mediated apoptosis of beta-cells, leading to improved glucose tolerance and beta-cell function. These protective effects against beta-cell death and diabetes development suggest the therapeutic potential of autophagy enhancers in human diabetes with islet amyloid accumulation.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Kihyoun Park, Hyejin Lim, Jinyoung Kim, Yeseong Hwang, Yu Seol Lee, Soo Han Bae, Hyeongseok Kim, Hail Kim, Shin-Wook Kang, Joo Young Kim, Myung-Shik Lee
Summary: This study reveals the crucial role of lysosomal calcium release in promoting mitophagy and maintaining pancreatic beta-cell function. The activation of transcription factor EB (TFEB) through lysosomal calcium release leads to increased mitophagy, while the loss of beta-cell TFEB aggravates glucose intolerance during high-fat diet.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Jinyoung Kim, Soyeon Lee, Myung-Shik Lee
Summary: Autophagy deficiency could play a role in tumorigenesis. When the autophagy-related 7 gene is disrupted in insulin target tissues, it induces the production of FGF21. FGF21 affects tumor growth, so we hypothesized that FGF21 produced by hepatocytes with Atg7 gene knockout may affect the behavior of hepatoma in an autocrine manner. The results showed that the knockout of both Atg7 and Fgf21 significantly increased the number and size of hepatoma, reduced YAP1 degradation, and led to increased accumulation of ROS and DNA damage. These findings suggest that FGF21 produced by autophagy-deficient hepatocytes may have an impact on the number and proliferation of hepatoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Kihyoun Park, Seong Keun Sonn, Seungwoon Seo, Jinyoung Kim, Kyu Yeon Hur, Goo Taeg Oh, Myung-Shik Lee
Summary: The immunosuppressive drug FK506 inhibits mitophagy and impairs mitochondrial function in pancreatic beta-cells, leading to reduced insulin release and impaired glucose tolerance. Activation of TFEB, a key regulator of lysosomal biogenesis and autophagy gene expression, can ameliorate FK506-induced mitochondrial dysfunction and glucose intolerance by enhancing autophagy.
Article
Microbiology
Hae-In Joe, Jee-Won Choi, June-Young Lee, Hojun Sung, Su-Won Jeong, Yun-Seok Jeong, Jae-Yun Lee, Jin-Woo Bae
Summary: Three new bacterial strains, 321(T), 335(T), and 353(T), were isolated from the intestines of Aegosoma sinicum larvae collected in Paju-Si, South Korea. These strains belong to the genus Luteibacter and are characterized as Gram-negative, obligate aerobes with rod-shaped cells and a single flagellum. Through genomic analysis, it is determined that these strains are novel species within the genus Luteibacter.
JOURNAL OF MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Jinyoung Kim, Seong Hun Kim, Hyereen Kang, Soyeon Lee, Shi-Young Park, Yoonil Cho, Yu-Mi Lim, Ji Woong Ahn, Young-Hwan Kim, Seungsoo Chung, Cheol Soo Choi, Yeon Jin Jang, Hye Soon Park, Yoonseok Heo, Kook Hwan Kim, Myung-Shik Lee
Summary: Kim et al. demonstrate that TFEB expression plays a protective role in diet-induced obesity by activating GDF15. Overexpression of TFEB can alleviate diet-induced obesity, while its deletion can exacerbate adipose tissue inflammation and insulin resistance.
Review
Biochemistry & Molecular Biology
Jinyoung Kim, Yu-Mi Lim, Myung-Shik Lee
MOLECULES AND CELLS
(2018)
Article
Biochemistry & Molecular Biology
Tae Woong Whon, Na-Ri Shin, Mi-Ja Jung, Dong-Wook Hyun, Hyun Sik Kim, Pil Soo Kim, Jin-Woo Bae
ANTIOXIDANTS & REDOX SIGNALING
(2017)