Article
Biochemistry & Molecular Biology
Tomohiro Komatsu, Satomi Abe, Shihoko Nakashima, Kei Sasaki, Yasuki Higaki, Keijiro Saku, Shin-ichiro Miura, Yoshinari Uehara
Summary: Sitagliptin phosphate, a DPP-4 inhibitor, increases cholesterol efflux from foam cells and may have anti-atherosclerotic effects independent of glucose metabolism improvements.
Article
Immunology
Mingzhe Zhu, Xue Wang, Kai Wang, Zhiqiang Zhao, Yanqi Dang, Guang Ji, Fenghua Li, Wenjun Zhou
Summary: The study found that Lingguizhugan decoction can partially alleviate non-alcoholic steatohepatitis by modulating gut microbiota and correlated metabolites. In an animal experiment, four weeks of Lingguizhugan decoction treatment improved the features of methionine- and choline-deficient diet-induced fatty liver disease, and also changed the relative abundance of gut microbial community and metabolites.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Wen Wang, Xiaojing Liu, Peiyao Wei, Feng Ye, Yunru Chen, Lei Shi, Xi Zhang, Jianzhou Li, Shumei Lin, Xueliang Yang
Summary: This study identified hub genes and pathways involved in non-alcoholic steatohepatitis (NASH) using bioinformatics methods. SPP1 and CXCL9 were found to be the hub genes in NASH patients. Lipid metabolism, inflammatory response, and lymphocyte activation were identified as the most significant biological functions in NASH patients. The toll-like receptor signaling pathway was found to be significantly enriched in NASH patients. Further experimental studies are needed to confirm the results.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sangam Rajak, Pratima Gupta, Baby Anjum, Sana Raza, Archana Tewari, Sujoy Ghosh, Madhulika Tripathi, Brijesh K. Singh, Rohit A. Sinha
Summary: NASH is an important stage of NAFLD in humans, and there are currently no approved drugs for its treatment. The upregulation of AKR1B10 gene in NASH patients has been identified, and the inhibition of AKR1B10 has shown promising effects in reducing the pathological features of NASH.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Andrea Ferrigno, Lucrezia Irene Maria Campagnoli, Annalisa Barbieri, Nicoletta Marchesi, Alessia Pascale, Anna Cleta Croce, Mariapia Vairetti, Laura Giuseppina Di Pasqua
Summary: The endogenous antioxidant defense, regulated by HuR, plays a crucial role in the pathogenesis of NAFLD. HuR controls the stability of MnSOD and HO-1 mRNA, two enzymes that protect liver cells from oxidative damage. In an NAFLD animal model, downregulation of HuR was observed along with reduced expression of MnSOD and HO-1, which correlated with oxidative stress and mitochondrial dysfunction. Targeting HuR could be a potential therapeutic strategy for preventing and treating NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jarren R. Oates, Keisuke Sawada, Daniel A. Giles, Pablo C. Alarcon, Michelle S. M. A. Damen, Sara Szabo, Traci E. Stankiewicz, Maria E. Moreno-Fernandez, Senad Divanovic
Summary: Recent evidence suggests that housing temperature-induced alterations in hepatic inflammation correlate with exacerbated hepatic steatosis, development of hepatic fibrosis, and hepatocellular damage in a model of high fat diet-driven non-alcoholic fatty liver disease (NAFLD). However, the congruency of these findings across other frequently employed experimental mouse models of NAFLD has not been studied. This study examines the impact of housing temperature on different experimental models of NAFLD in mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Leslye Samano-Hernandez, Reyna Fierro, Aude Marchal, Jean-Louis Gueant, Humberto Gonzalez-Marquez, Rosa-Maria Gueant-Rodriguez
Summary: NAFLD is a common chronic liver disease, and the study indicates that sitagliptin treatment is not effective in preventing NAFLD development, and may even cause adverse effects in the MCD rat model.
Review
Biochemistry & Molecular Biology
Hideki Kitaura, Saika Ogawa, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Jinghan Ma, Kayoko Kanou, Itaru Mizoguchi
Summary: GLP-1 receptor agonists and DPP-4 inhibitors are effective in treating type 2 diabetes, but they may impact bone metabolism by enhancing bone marker expression and improving bone density. Furthermore, they have been reported to suppress chronic inflammation and reduce the expression of inflammatory cytokines, leading to decreased inflammation-induced bone resorption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Yang Yu, Lina Yu, Nuo Cheng, Xiaoguang Liu, Chunlu Fang, Shujing Liu, Lin Zhu
Summary: The study demonstrated that exercise can improve HFD-induced NASH by enhancing the inhibitory effects of ApoA5 on the TLR4-mediated NF-kappa B pathway, reducing hepatic lipid accumulation, inflammation, and fibrosis.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Kohei Kaku, Takashi Kadowaki, Yutaka Seino, Taro Okamoto, Masayoshi Shirakawa, Asako Sato, Edward A. O'Neill, Samuel S. Engel, Keith D. Kaufman
Summary: Adding ipragliflozin 50 mg once daily to sitagliptin 50 mg once daily monotherapy significantly improved glycemic control and was generally well tolerated in Japanese patients with type 2 diabetes.
DIABETES OBESITY & METABOLISM
(2021)
Article
Medicine, General & Internal
Qi Pan, Shushan Lin, Yu Li, Liang Liu, Xiaoping Li, Xianglei Gao, Jiangyu Yan, Baohua Gu, Xiaofeng Chen, Wenjia Li, Xinfa Tang, Chao Chen, Lixin Guo
Summary: Novel FGF21-Fc-GLP-1 dual-targeted constructs were developed with enhanced activity and prolonged half-life in vivo, showing promising effects in glucose lowering, weight loss, and anti-NASH in various experiments.
Article
Endocrinology & Metabolism
Simone Bastrup Israelsen, Anton Pottegard, Hakon Sandholdt, Sten Madsbad, Reimar Wernich Thomsen, Thomas Benfield
Summary: This population-based cohort study found that the use of incretin-based therapies, GLP-1 RAs and DPP-4i, in individuals with diabetes and SARS-CoV-2 infection did not result in improved clinical outcomes compared to SGLT-2i.
DIABETES OBESITY & METABOLISM
(2021)
Article
Health Care Sciences & Services
Chia-Jen Tsai, Cheng-Feng Tsao
Summary: This study evaluated the efficacy of glucose control in type 2 diabetes patients who switched from DPP-4 inhibitors to GLP-1 receptor agonists. The results showed that there was a significant reduction in HbA1c levels after initiating GLP-1 RAs in both DPP-4 inhibitor users and non-users. Non-users of DPP-4 inhibitors had a greater reduction in HbA1c levels compared to users, indicating better glucose control.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Shigenori Hiruma, Fumika Shigiyama, Naoki Kumashiro
Summary: This study compared the effects of SGLT2 inhibitors and DPP-4 inhibitors on ectopic fat accumulation and tissue-specific insulin sensitivity. The results showed that empagliflozin significantly improved hepatic steatosis compared with sitagliptin, and this may protect against subsequent hepatic insulin resistance. Therefore, early administration of SGLT2 inhibitors is preferable for T2D patients with NAFLD.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Yutaka Seino, Kohei Kaku, Takashi Kadowaki, Taro Okamoto, Asako Sato, Masayoshi Shirakawa, Edward A. O'Neill, Samuel S. Engel, Keith D. Kaufman
Summary: In Japanese patients with type 2 diabetes, adding sitagliptin to ipragliflozin monotherapy provided significant improvement in glycemic control and was generally well tolerated.
DIABETES OBESITY & METABOLISM
(2021)
Article
Cell Biology
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Yu Na Kang, Jae Seok Hwang, Keun-Gyu Park, Mi Kyung Kim, Byoung Kuk Jang
Article
Nutrition & Dietetics
Jung Gil Park, Won Young Tak, Soo Young Park, Young Oh Kweon, Woo Jin Chung, Byoung Kuk Jang, Si Hyun Bae, Heon Ju Lee, Jae Young Jang, Ki Tae Suk, Myung Jin Oh, Jeong Heo, Hyun Young Woo, Se Young Jang, Yu Rim Lee, June Sung Lee, Do Young Kim, Seok Hyun Kim, Jeong Ill Suh, In Hee Kim, Min Kyu Kang, Won Kee Lee
Article
Gastroenterology & Hepatology
Young-Hwan Ahn, Heirim Lee, Do Young Kim, Hye Won Lee, Su Jong Yu, Young Youn Cho, Jeong Won Jang, Byoung Kuk Jang, Chang Wook Kim, Hee Yeon Kim, Hana Park, Hyo Jung Cho, Bumhee Park, Soon Sun Kim, Jae Youn Cheong
Summary: This study evaluated the efficacy of DAA therapy in Korean patients with HCV-related HCC and found a correlation between short last HCC treatment duration and HCC recurrence. The results suggest that the last HCC treatment duration is an important predictor of HCC recurrence after DAA therapy.
Article
Multidisciplinary Sciences
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Jae Seok Hwang, Mi Kyung Kim, Byoung Kuk Jang
Article
Biochemistry & Molecular Biology
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Jae-Ho Lee, Byoung Kuk Jang, Mi Kyung Kim
Summary: The study found that kahweol induces apoptosis in hepatocellular carcinoma cells by inhibiting the phosphorylation of specific signaling pathways, suggesting it as a potential inhibitor of HCC cell growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Eugene Han, Mi Kyung Kim, Seung-Soon Im, Hye Soon Kim, Taeg Kyu Kwon, Byoung Kuk Jang
Summary: This study investigated the association between high sodium intake and the risk of sarcopenia and nonalcoholic fatty liver disease (NAFLD). The results showed that participants with high urinary sodium excretion had a significantly higher risk of NAFLD and sarcopenia.
Article
Biochemistry & Molecular Biology
Hye-Young Seo, So-Hee Lee, Eugene Han, Jae Seok Hwang, Sol Han, Mi Kyung Kim, Byoung Kuk Jang
Summary: In this study, we found that evogliptin can inhibit inflammatory and fibrotic signaling in liver cells and induce autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Hye-Young Seo, So-Hee Lee, Eugene Han, Jae Seok Hwang, Mi Kyung Kim, Byoung Kuk Jang
Summary: Autophagy deficiency leads to increased expression of fibrosis-associated genes in liver cells, causing liver injury.
Article
Chemistry, Analytical
Dae Hoon Kim, Hae Shin Cho, Jin Heung Kim, Da Ae Jo, Hong Gi Oh, Byoung Kuk Jang, Kwang Soup Song
Summary: In this study, we successfully integrated fluorinated reduced graphene oxide (F-rGO) as a new reference electrode (RE) in microscale ion-sensitive field-effect transistors (ISFETs) sensors. The F-rGO RE showed stable operation, high sensitivity, and low hysteresis voltage, enabling fast and accurate detection of specific ions in solution.
Article
Oncology
Jina Kim, Jason Chia-Hsien Cheng, Taek-Keun Nam, Jin Hee Kim, Byoung Kuk Jang, Wen-Yen Huang, Hiroshi Aikata, Myungsoo Kim, Jung Hyun Kwon, Jinbo Yue, Victor Ho Fun Lee, Zhaochong Zeng, Jinsil Seong
Summary: This study compared the efficacy of liver-directed combined radiotherapy (LD combined RT) with sorafenib in hepatocellular carcinoma patients presenting portal vein tumor thrombosis. The LD combined RT group showed significantly improved overall survival and a higher conversion rate to curative surgery. Despite the multimodality of the treatment, LD combined RT had comparable toxicity rates to sorafenib.
Article
Multidisciplinary Sciences
Hye-Young Seo, So-Hee Lee, Ji Yeon Park, Eugene Han, Sol Han, Jae Seok Hwang, Mi Kyung Kim, Byoung Kuk Jang
Summary: This study demonstrates the potential of lobeglitazone in inhibiting liver inflammation and fibrosis by reducing NLRP3 inflammasome activation and production of proinflammatory cytokines.
Article
Medicine, General & Internal
Jae Yong Lee, So Yeon Lee, Yoo Jin Lee, Jin Wook Lee, Jeong Seok Kim, Ju Yup Lee, Byoung Kuk Jang, Woo Jin Chung, Kwang Bum Cho, Jae Seok Hwang
Summary: This study found that serum PCT and CRP have limited value in differentiating between bacterial and nonbacterial colitis, and are not effective in discriminating between the two conditions.
JOURNAL OF YEUNGNAM MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Seung Wan Kim, Byoung Kuk Jang
Summary: This article reports a case of a 39-year-old woman diagnosed with a liver abscess caused by co-infection of Toxocara canis and Fasciola hepatica. The patient may have acquired the infections through ingestion of eggs from contaminated soil and consumption of contaminated water or aquatic plants.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Hyung Joon Kim, Ju Hyun Kim, Jong Eun Yeon, Yeon Seok Seo, Jeong Won Jang, Yong Kyun Cho, Byoung Kuk Jang, Byung Hoon Han, Changhyeong Lee, Joon Hyeok Lee, Jung-Hwan Yoon, Kang Mo Kim, Moon Young Kim, Do Young Kim, Neung Hwa Park, Eun Young Cho, June Sung Lee, Jin-Woo Lee, In Hee Kim, Byung-Cheol Song, Byung-Seok Lee, Oh Sang Kwon
Summary: This study demonstrates that DA-2802 is an effective and safe treatment option for patients with chronic hepatitis B. After 48 weeks of treatment, there was a significant reduction in HBV DNA levels in the DA-2802 group. There were no significant differences in the secondary efficacy endpoints between the two groups, and the frequency of adverse events was similar.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Won Young Jang, Woo Jin Chung, Byoung Kuk Jang, Jae Seok Hwang, Heon Ju Lee, Moon Joo Hwang, Young Oh Kweon, Won Young Tak, Soo Young Park, Su Hyun Lee, Chang Hyeong Lee, Byung Seok Kim, Si Hye Kim, Jeong Ill Suh, Jun Gi Park
JOURNAL OF KOREAN MEDICAL SCIENCE
(2020)