Untangling Tau and Iron: Exploring the Interaction Between Iron and Tau in Neurodegeneration

Metals and Alzheimer’s Disease: How Far Have We Come in the Clinic?

(2018) Paul A. Adlard et al.   JOURNAL OF ALZHEIMERS DISEASE

Deferiprone Reduces Amyloid-β and Tau Phosphorylation Levels but not Reactive Oxygen Species Generation in Hippocampus of Rabbits Fed a Cholesterol-Enriched Diet

(2018) Jaya R.P. Prasanthi et al.   JOURNAL OF ALZHEIMERS DISEASE

Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease

(2017) Michael P. Gotsbacher et al.   Metallomics

Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer's disease

(2017) Veena Theendakara et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation

(2017) Eleonora Carboni et al.   NEUROMOLECULAR MEDICINE

α-Synuclein impairs ferritinophagy in the retinal pigment epithelium: Implications for retinal iron dyshomeostasis in Parkinson’s disease

(2017) Shounak Baksi et al.   Scientific Reports

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

(2017) David I. Finkelstein et al.   Acta Neuropathologica Communications

NMR Studies of Zinc, Copper, and Iron Binding to Histidine, the Principal Metal Ion Complexing Site of Amyloid-β Peptide

(2017) Nanditha G. Nair et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

(2017) Antonio Martin-Bastida et al.   Scientific Reports

Iron Regulates Apolipoprotein E Expression and Secretion in Neurons and Astrocytes

(2016) He Xu et al.   JOURNAL OF ALZHEIMERS DISEASE

Iron-induced oxidative stress activates AKT and ERK1/2 and decreases Dyrk1B and PRMT1 in neuroblastoma SH-SY5Y cells

(2016) Elizabeth Bautista et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

PP2A methylation controls sensitivity and resistance to β-amyloid–induced cognitive and electrophysiological impairments

(2016) Russell E. Nicholls et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment

(2016) J. M. G. van Bergen et al.   Scientific Reports

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

(2015) Keith A. Vossel et al.   JOURNAL OF CELL BIOLOGY

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories

(2015) C. E. Arber et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

(2015) Scott Ayton et al.   Nature Communications

Hyperphosphorylation of Intrinsically Disordered Tau Protein Induces an Amyloidogenic Shift in Its Conformational Ensemble

(2015) Shaolong Zhu et al.   PLoS One

Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice

(2014) Tomohiro Umeda et al.   ACTA NEUROPATHOLOGICA

Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease

(2014) Bidisha Roy et al.   HUMAN MOLECULAR GENETICS

Tau pathology involves protein phosphatase 2A in Parkinsonism-dementia of Guam

(2014) M. Arif et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration

(2013) Naomi Kouri et al.   ACTA NEUROPATHOLOGICA

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology

(2013) Beatriz G. Perez-Nievas et al.   BRAIN

Potential clinical applications of chelating drugs in diseases targeting transferrin-bound iron and other metals

(2013) Christina N Kontoghiorghe et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

(2013) M. Goedert et al.   Cold Spring Harbor Perspectives in Medicine

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Lack of Tau Proteins Rescues Neuronal Cell Death and Decreases Amyloidogenic Processing of APP in APP/PS1 Mice

(2012) Karelle Leroy et al.   AMERICAN JOURNAL OF PATHOLOGY

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

(2012) Giovanni Coppola et al.   HUMAN MOLECULAR GENETICS

Excess iron harms the brain: the syndromes of neurodegeneration with brain iron accumulation (NBIA)

(2012) Susanne A. Schneider et al.   JOURNAL OF NEURAL TRANSMISSION

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease

(2012) Chuang Guo et al.   NEUROBIOLOGY OF AGING

Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain

(2012) Chuang Guo et al.   NEUROCHEMISTRY INTERNATIONAL

Progressive Supranuclear Palsy: High-Field-Strength MR Microscopy in the Human Substantia Nigra and Globus Pallidus

(2012) Parastou Foroutan et al.   RADIOLOGY

Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice

(2012) J. M. Fine et al.   EXPERIMENTAL BRAIN RESEARCH

Glycogen synthase kinase-3β regulates Tyr307phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src

(2011) Xiu-Qing Yao et al.   BIOCHEMICAL JOURNAL

Expression of divalent metal transporter 1 in primary hippocampal neurons: reconsidering its role in non-transferrin-bound iron influx

(2011) Ilaria Pelizzoni et al.   JOURNAL OF NEUROCHEMISTRY

Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models

(2011) Preeti J. Khandelwal et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouse

(2011) Jonathan Gilley et al.   NEUROBIOLOGY OF AGING

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Mice lacking phosphatase PP2A subunit PR61/B'  (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3 

(2011) J. V. Louis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model

(2010) David E. Hurtado et al.   AMERICAN JOURNAL OF PATHOLOGY

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment

(2010) Xiaochuan Wang et al.   FASEB JOURNAL

Tau protein: Relevance to Parkinson's disease

(2010) Peng Lei et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1

(2010) Hyun-Hee Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Animal models reveal role for tau phosphorylation in human disease

(2009) Jürgen Götz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aβ exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease

(2009) James Folwell et al.   EXPERIMENTAL NEUROLOGY

ApoE isoform-dependent changes in hippocampal synaptic function

(2009) Kimberly M Korwek et al.   Molecular Neurodegeneration

Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits

(2009) Elena Gómez de Barreda et al.   NEUROBIOLOGY OF DISEASE

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY

Domain Conformation of Tau Protein Studied by Solution Small-Angle X-ray Scattering†

(2008) Efstratios Mylonas et al.   BIOCHEMISTRY

Inhibition of glycogen synthase kinase-3β downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A

(2008) Ludovic Martin et al.   BRAIN RESEARCH

Structural Mechanism of Demethylation and Inactivation of Protein Phosphatase 2A

(2008) Yongna Xing et al.   CELL

Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging

(2008) Emily L. Que et al.   CHEMICAL REVIEWS

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin

(2008) Inmaculada Cuchillo-Ibanez et al.   FASEB JOURNAL

Direct analysis of tau from PSP brain identifies new phosphorylation sites and a major fragment of N-terminally cleaved tau containing four microtubule-binding repeats

(2008) Selina Wray et al.   JOURNAL OF NEUROCHEMISTRY

Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

(2008) Yanhui Xu et al.   MOLECULAR CELL

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE