Article
Biochemistry & Molecular Biology
Jizhong Han, Huajiang Deng, Yu Xiong, Xiangguo Xia, Changshun Bao, Ligang Chen, Qin Zhao, Shunjie Zhong, Lilei Peng, Chuanhong Zhong
Summary: This study found that reduced expression of PTCH2 was associated with poor prognosis in glioma patients. Overexpression of PTCH2 suppressed the proliferation and invasion of glioma cells. Mechanistically, PTCH2 upregulated PTEN expression to inhibit AKT signals and glioma development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Yongwei Lu, Qiaoyan Lin, Cuibo Lin, Jian Chen, Xinyan Jiang, Haixi He
Summary: The study suggests that miR-424 inhibitor can inhibit cell proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) process, while promoting apoptosis in endometrial carcinoma (EC) by suppressing PTEN/PI3K/AKT signaling. However, the effects of miR-424 inhibitor were reversed by sh-PTEN.
Review
Medicine, General & Internal
Xuefeng Bai, Shaowei Wang
Summary: Premature ovarian failure (POF) is a multifactorial disease characterized by secondary amenorrhea, decreased estrogen levels, and increased gonadotropin levels in women under 40. The prevalence of POF is increasing and it has adverse effects on both the physiology and psychology of women. Hormone replacement therapy is the recommended treatment, and a multidisciplinary approach is needed to improve patients' quality of life. Recent studies suggest that the depletion of ovarian reserve function due to increased primordial follicular activation or insufficiency is the primary mechanism of POF. Therefore, understanding the processes and pathways involved in primordial follicle activation and exploring effective interventions are crucial for POF treatment.
FRONTIERS IN MEDICINE
(2022)
Article
Neurosciences
Tatsuhiro Shimizu, Kayoko Sugiura, Yoshiki Sakai, Abdul R. Dar, Rebecca A. Butcher, Kunihiro Matsumoto, Naoki Hisamoto
Summary: Chemical communication plays a crucial role in axon regeneration, and the ascaroside signaling system serves as a unique example of regulating the regenerative pathway in the nervous system.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Yongbo Hu, Yiming He, Wei Liu, Shun Yu, Yabing Wei, Shaohua Bai, Yu Su, Bin Xiao
Summary: SIAH2 acts as an oncogene in colorectal cancer, promoting tumor proliferation, migration, and invasion. It activates the PI3K/AKT signaling pathway and is regulated by PTEN loss.
Review
Chemistry, Medicinal
Md Junaid, Yeasmin Akter, Syeda Samira Afrose, Mousumi Tania, Md Asaduzzaman Khan
Summary: AKT is a crucial enzyme in cancer development, and the natural compound TQ found in black cumin has shown potential anti-cancer activities by inhibiting AKT signaling pathways. Despite the development of numerous drugs targeting AKT, only a few have successfully passed clinical trials.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Review
Cell Biology
Bart Nieuwenhuis, Richard Eva
Summary: This article reviews the role of the PI3-kinase and PTEN signaling pathway in promoting repair of the injured central nervous system. Genetic deletion of PTEN has been shown to stimulate optic nerve regeneration, and the PI3-kinase and PIP3 signaling pathways play critical roles in developmental and regenerative axon growth. The article also discusses the neuron-intrinsic mechanisms that control regenerative ability and how they are affected by PI3-kinase signaling. Furthermore, the article highlights the recent finding of a decline in PIP3 generation as a key reason for regenerative failure, and summarizes studies targeting an increase in signaling downstream of PI3-kinase to facilitate regeneration in the adult central nervous system. The article concludes by discussing obstacles that need to be overcome in order to develop a robust strategy for repairing the injured central nervous system through manipulation of PI3-kinase signaling.
NEURAL REGENERATION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Qin Ru, Xiang Tian, Qi Xiong, Congyue Xu, Lin Chen, Yuxiang Wu
Summary: The study found that krill oil can significantly improve memory deficits induced by METH, and identified 20 hub genes including DRD2, MAPK3, CREB, BDNF, and caspase-3 through network pharmacology analysis, revealing the mechanisms by which it exerts its neuroprotective effects through the MAPK signaling pathway and dopaminergic synapse pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Hematology
Ronen Siman-Tov, Natalie Zelikson, Michal Caspi, Yakir Levi, Chava Perry, Fayhaa Khair, Hagit Stauber, Josue Sznitman, Rina Rosin-Arbesfeld
Summary: This study demonstrates the expression of components of the noncanonical Wnt pathway in erythrocytes and shows that Wnt ligands can enhance the flexibility and strength of erythrocyte cytoskeleton, leading to prolonged survival in the circulation. The research also indicates that Wnt-5A ligand is secreted into plasma, with monocytes and lymphocytes as possible sources, highlighting potential new avenues for studying signaling pathways in the bloodstream.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Neurosciences
Aishwarya Mary Johnson, Sara Jose, Abdul Rasheed Palakkott, Farheen Badrealam Khan, Nanthini Jayabalan, Jaleel Kizhakkayil, Shamma Abdulla Ali AlNaqbi, Mark G. H. Scott, Mohammed Akli Ayoub, Richard Gordon, Hariharan Saminathan
Summary: Parkinson's disease is a progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons. Fyn kinase activation has been identified as an early signaling event in PD, and PTEN may be the upstream regulator of Fyn activation. By modulating PTEN activity, dopaminergic neurons can be protected from neurotoxicity and mitochondrial dysfunction in PD.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2023)
Review
Cell Biology
Santiago Vidal, Yanis Hichem Bouzaher, Ahmed El Motiam, Rocio Seoane, Carmen Rivas
Summary: The PI3K/AKT pathway, regulated by SUMOylation, plays a crucial role in various physiological processes and may be involved in human diseases.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Ying Lan, Lvlin Chen, Juncheng Zhu, Hui Li, Zhimei Lin
Summary: The side effects of chemotherapy drugs, especially hepatotoxicity, have hindered tumor treatment. Scutellarein (Sc), a potential Chinese herbal monomer, has been found to exhibit liver protection activity. This study used THP to induce hepatotoxicity in rats and found that Sc effectively alleviated liver inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Xubin Hou, Motohiro Nozumi, Harukazu Nakamura, Michihiro Igarashi, Sayaka Sugiyama
Summary: In this study, the researchers investigated the role of the ADF-H domain-containing protein coactosin in axon growth, finding that coactosin promotes the assembly of protrusive actin filament arrays at the leading edge of growth cones. The promotion of axonal growth by coactosin was shown to be dependent on the activity of cofilin.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Xuanqing Chen, Tingting Xu, Xiangyu Lv, Jingwei Zhang, Shijia Liu
Summary: The study found that Rh2 exhibits potential application value in the treatment of ulcerative colitis (UC), and its mechanism is related to the downregulation of STAT3/miR-214 levels.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chinh Thanh Nguyen, Van Minh Nguyen, Sangyun Jeong
Summary: The role of Off-track receptor tyrosine kinase (OTK) in motor axon pathfinding in Drosophila is not well understood. This study found that OTK mediates forward and reverse signaling in intersegmental nerve b (ISNb) motor axon pathfinding and interacts with the Sema-1a/PlexA and Wnt signaling pathways.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Keiichi Inoue, Luis M. A. Oliveira, Asa Abeliovich
Review
Neurosciences
Liang Qiang, Keiichi Inoue, Asa Abeliovich
BIOLOGICAL PSYCHIATRY
(2014)
Article
Neurosciences
Keiichi Inoue, Joanne Rispoli, Hanoch Kaphzan, Eric Klann, Emily I. Chen, Jongpil Kim, Masaaki Komatsu, Asa Abeliovich
MOLECULAR NEURODEGENERATION
(2012)
Article
Multidisciplinary Sciences
Claudia A. Doege, Keiichi Inoue, Toru Yamashita, David B. Rhee, Skylar Travis, Ryousuke Fujita, Paolo Guarnieri, Govind Bhagat, William B. Vanti, Alan Shih, Ross L. Levine, Sara Nik, Emily I. Chen, Asa Abeliovich
Article
Multidisciplinary Sciences
Ryoko Igarashi, Shun-ichi Yamashita, Tomohiro Yamashita, Keiichi Inoue, Tomoyuki Fukuda, Takeo Fukuchi, Tomotake Kanki
SCIENTIFIC REPORTS
(2020)
Article
Biology
Aleksei Innokentev, Kentaro Furukawa, Tomoyuki Fukuda, Tetsu Saigusa, Keiichi Inoue, Shun-ichi Yamashita, Tomotake Kanki
Article
Cell Biology
Shun-Ichi Yamashita, Masanao Kyuuma, Keiichi Inoue, Yuki Hata, Ryu Kawada, Masaki Yamabi, Yasuyuki Fujii, Junko Sakagami, Tomoyuki Fukuda, Kentaro Furukawa, Satoshi Tsukamoto, Tomotake Kanki
Summary: The study found that muscle disuse enhances mitophagy activity and the production of reactive oxygen species in atrophic skeletal muscles, suggesting a potential therapeutic target for disuse-induced muscle atrophy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Neurosciences
Keiichi Inoue
Summary: Analyzing an appropriate disease model system is crucial for disease research, aiding in understanding pathological mechanisms, developing new therapies, and advancing personalized medicine. Challenges exist in collecting neuronal cells from patients with neurodegenerative disorders, but skin fibroblasts may not fully exhibit expected pathology. A new in vitro model system utilizing CRISPR technology to activate disease-relevant genes in patient fibroblast cultures offers a platform for analyzing neurodegenerative disorders.
NEUROSCIENCE RESEARCH
(2021)
Article
Cell Biology
Tomoyuki Fukuda, Tetsu Saigusa, Kentaro Furukawa, Keiichi Inoue, Shun-ichi Yamashita, Tomotake Kanki
Summary: The endoplasmic reticulum (ER) undergoes selective autophagy called reticulophagy or ER-phagy. Reticulon- and receptor expression enhancing protein (REEP)-like ER-shaping proteins, such as budding yeast Atg40, act as reticulophagy receptors to stabilize the phagophore on the ER by interacting with phagophore-conjugated Atg8. Hva22, a REEP family protein in fission yeast, promotes reticulophagy without Atg8-binding capacity and its role can be replaced by expressing Atg40 independently of its Atg8-binding ability.
Article
Biology
Tomoyuki Fukuda, Yuki Ebi, Tetsu Saigusa, Kentaro Furukawa, Shun-ichi Yamashita, Keiichi Inoue, Daiki Kobayashi, Yutaka Yoshida, Tomotake Kanki
Article
Ophthalmology
Kseniia Chernyshova, Keiichi Inoue, Shun-Ichi Yamashita, Takeo Fukuchi, Tomotake Kanki
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Article
Multidisciplinary Sciences
Jongpil Kim, Keiichi Inoue, Jennifer Ishii, William B. Vanti, Sergey V. Voronov, Elizabeth Murchison, Gregory Hannon, Asa Abeliovich
Article
Neurosciences
David MacLeod, Julia Dowman, Rachel Hammond, Thomas Leete, Keiichi Inoue, Asa Abeliovich
Article
Biochemistry & Molecular Biology
Keiichi Inoue, Yuko Mikuni-Takagaki, Kaoru Oikawa, Takeshi Itoh, Masaki Inada, Takanori Noguchi, Jin-Sung Park, Takashi Onodera, Stephen M. Krane, Masaki Noda, Shigeyoshi Itohara
JOURNAL OF BIOLOGICAL CHEMISTRY
(2006)