Characterization of the Cartilage DNA Methylome in Knee and Hip Osteoarthritis

On the presence and role of human gene-body DNA methylation

(2015) Daudi Jjingo et al.   Oncotarget

Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients

(2013) Juan Fernández-Tajes et al.   ANNALS OF THE RHEUMATIC DISEASES

A data-driven approach to preprocessing Illumina 450K methylation array data

(2013) Ruth Pidsley et al.   BMC GENOMICS

Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites

(2013) Ko Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-β and osteoarthritis—the good and the bad

(2013) Jason R Bush et al.   NATURE MEDICINE

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Insights from human genetic studies into the pathways involved in osteoarthritis

(2013) Louise N. Reynard et al.   Nature Reviews Rheumatology

An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype

(2013) John W Whitaker et al.   Genome Medicine

Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes

(2012) María C. de Andrés et al.   ARTHRITIS AND RHEUMATISM

cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis

(2012) Catherine Bui et al.   FASEB JOURNAL

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs

(2012) M.J. Barter et al.   OSTEOARTHRITIS AND CARTILAGE

Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA

(2012) Y. Xu et al.   OSTEOARTHRITIS AND CARTILAGE

Distinct DNA methylomes of newborns and centenarians

(2012) H. Heyn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for age-related changes in TGFβ signaling in aberrant chondrocyte differentiation and osteoarthritis

(2012) Peter M van der Kraan et al.   ARTHRITIS RESEARCH & THERAPY

Complete pipeline for Infinium® Human Methylation 450K BeadChip data processing using subset quantile normalization for accurate DNA methylation estimation

(2012) Nizar Touleimat et al.   Epigenomics

Age-dependent alteration of TGF-β signalling in osteoarthritis

(2011) Peter M. van der Kraan et al.   CELL AND TISSUE RESEARCH

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation

(2011) Louise N. Reynard et al.   HUMAN MOLECULAR GENETICS

DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter

(2011) Han Han et al.   HUMAN MOLECULAR GENETICS

Genetics and epigenetics of osteoarthritis

(2011) Louise N. Reynard et al.   MATURITAS

Cancer epigenetics reaches mainstream oncology

(2011) Manuel Rodríguez-Paredes et al.   NATURE MEDICINE

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

DNA demethylation at specific CpG sites in theIL1Bpromoter in response to inflammatory cytokines in human articular chondrocytes

(2009) Ko Hashimoto et al.   ARTHRITIS AND RHEUMATISM

SASP reflects senescence

(2009) Andrew R J Young et al.   EMBO REPORTS

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

(2009) Akiko Doi et al.   NATURE GENETICS

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis

(2009) P.M. van der Kraan et al.   OSTEOARTHRITIS AND CARTILAGE

Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line

(2008) E. N. Gal-Yam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation

(2008) Kelvin S. C. Cheung et al.   RHEUMATOLOGY INTERNATIONAL