Regulation of insulin resistance and glucose metabolism by interaction of PIM kinases and insulin receptor substrates

Mechanistically different effects of fat and sugar on insulin resistance, hypertension, and gut microbiota in rats

(2018) Sara Ramos-Romero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action

(2018) Atefeh Rabiee et al.   CELLULAR SIGNALLING

Chronic hyperinsulinemia induced miR-27b is linked to adipocyte insulin resistance by targeting insulin receptor

(2018) Ankita Srivastava et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Circulating bone morphogenetic protein-9 levels are associated with hypertension and insulin resistance in humans

(2018) Hong Huang et al.   Journal of the American Society of Hypertension

IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

(2018) Yosuke Yoneyama et al.   eLife

Insulin Receptor Substrate 2 Controls Insulin-Mediated Vasoreactivity and Perivascular Adipose Tissue Function in Muscle

(2018) Alexander H. Turaihi et al.   Frontiers in Physiology

Endoplasmic reticulum stress epigenetics is related to adiposity, dyslipidemia, and insulin resistance

(2018) Omar Ramos-Lopez et al.   Adipocyte

Microcystin-LR disrupts insulin signaling by hyperphosphorylating insulin receptor substrate 1 and glycogen synthase

(2017) Jinghui Liu et al.   ENVIRONMENTAL TOXICOLOGY

Insulin resistance increases the risk of incident type 2 diabetes mellitus in patients with non-alcoholic fatty liver disease

(2017) Yuya Seko et al.   HEPATOLOGY RESEARCH

Bilobalide abates inflammation, insulin resistance and secretion of angiogenic factors induced by hypoxia in 3T3-L1 adipocytes by controlling NF-κB and JNK activation

(2017) A Priyanka et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CDC25 Inhibition in Acute Myeloid Leukemia–A Study of Patient Heterogeneity and the Effects of Different Inhibitors

(2017) Annette Brenner et al.   MOLECULES

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling

(2017) Mee-Sup Yoon   Nutrients

Anti-TNF-α antibody alleviates insulin resistance in rats with sepsis-induced stress hyperglycemia

(2017) W. Qu et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Insulin receptor substrate 1 is a substrate of the Pim protein kinases

(2016) Jin H. Song et al.   Oncotarget

Intrinsic resistance to PIM kinase inhibition in AML through p38α-mediated feedback activation of mTOR signaling

(2016) Diede Brunen et al.   Oncotarget

eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants

(2016) Ke Chen et al.   Oncotarget

Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production

(2016) Matthijs P. Groeneveld et al.   Scientific Reports

mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR

(2015) Yancun Yin et al.   CELL RESEARCH

Analysis of insulin receptor substrate signaling dynamics on microstructured surfaces

(2015) Peter Lanzerstorfer et al.   FEBS Journal

PIM kinase (and Akt) biology and signaling in tumors

(2015) Noel A. Warfel et al.   PHARMACOLOGY & THERAPEUTICS

The esoteric roles of Bcl-2 family proteins in glucose homeostasis and cell survival

(2015) S Pfeiffer et al.   Cell Death & Disease

The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins

(2015) Fumihiko Hakuno et al.   Frontiers in Endocrinology

Abstract 4089: Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.

(2014) Douglas Linn et al.   CANCER RESEARCH

The Pim-1 Protein Kinase Is an Important Regulator of MET Receptor Tyrosine Kinase Levels and Signaling

(2014) B. Cen et al.   MOLECULAR AND CELLULAR BIOLOGY

Deletion of Pim kinases elevates the cellular levels of reactive oxygen species and sensitizes to K-Ras-induced cell killing

(2014) J H Song et al.   ONCOGENE

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Association of Gly972Arg variant of insulin receptor subtrate-1 and Gly1057Asp variant of insulin receptor subtrate-2 with polycystic ovary syndrome in the Chinese population

(2014) Ming-Wei Lin et al.   Journal of Ovarian Research

Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2): Figure 1

(2013) Michael A. DeStefano et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design

(2013) Xiaojing Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation

(2013) J. Lu et al.   BLOOD

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice

(2013) L. Soucek et al.   GENES & DEVELOPMENT

The AP-1 Complex Regulates Intracellular Localization of Insulin Receptor Substrate 1, Which Is Required for Insulin-Like Growth Factor I-Dependent Cell Proliferation

(2013) Y. Yoneyama et al.   MOLECULAR AND CELLULAR BIOLOGY

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Association of IRS-1 and IRS-2 genes polymorphisms with polycystic ovary syndrome: a meta-analysis

(2012) Yuan Ruan et al.   ENDOCRINE JOURNAL

Reduction of insulin signalling pathway IRS-1/IRS-2/AKT/mTOR and decrease of epithelial cell proliferation in the prostate of glucocorticoid-treated rats

(2012) Maitê M. Costa et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors

(2012) Marjo Malinen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

(2012) Anirudh Prahallad et al.   NATURE

The PIM kinases in hematological cancers

(2012) Yesid Alvarado et al.   Expert Review of Hematology

Loss of Estrogen Receptor a Signaling Leads to Insulin Resistance and Obesity in Young and Adult Female Mice

(2012) Camila Manrique et al.   CardioRenal Medicine

Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma

(2011) Jonathan H. Schatz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

(2011) D. Gaglio et al.   Molecular Systems Biology

PIM1 Protein Kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells

(2010) Fengxue Zhang et al.   CANCER BIOLOGY & THERAPY

Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

(2010) Carmen Blanco-Aparicio et al.   CANCER LETTERS

Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways

(2010) Y. C. Long et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

The Pim protein kinases regulate energy metabolism and cell growth

(2010) Z. Beharry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor

(2009) Colin W. Ward et al.   BIOESSAYS

Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

(2009) Jean-François Tanti et al.   CURRENT OPINION IN PHARMACOLOGY

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

(2009) Chunaram Choudhary et al.   MOLECULAR CELL

Polymorphisms of the insulin receptor and the insulin receptor substrates genes in polycystic ovary syndrome: A Mendelian randomization meta-analysis

(2009) Anastasios Ioannidis et al.   MOLECULAR GENETICS AND METABOLISM

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of IRS proteins, insulin action, and insulin resistance

(2008) Sigalit Boura-Halfon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation

(2008) Xiaocheng C. Dong et al.   Cell Metabolism

Effects of androgens on insulin action in women: is androgen excess a component of female metabolic syndrome?

(2008) A. Corbould   DIABETES-METABOLISM RESEARCH AND REVIEWS

Cyclin-dependent Kinase Inhibitor, p21WAF1/CIP1, Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to Obesity, and Insulin Resistance

(2008) Noriyuki Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Phosphotyrosine Interactome of the Insulin Receptor Family and Its Substrates IRS-1 and IRS-2

(2008) Stefan Hanke et al.   MOLECULAR & CELLULAR PROTEOMICS