IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression

(2017) Weikang Cai et al.   Nature Communications

Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis

(2016) Eunhee Choi et al.   CELL

Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2

(2016) Zuzana Kadlecova et al.   JOURNAL OF CELL BIOLOGY

Mapping growth-factor-modulated Akt signaling dynamics

(2016) Sean M. Gross et al.   JOURNAL OF CELL SCIENCE

Analysis of insulin receptor substrate signaling dynamics on microstructured surfaces

(2015) Peter Lanzerstorfer et al.   FEBS Journal

Tumor Necrosis Factor (TNF)-α-induced Repression of GKAP42 Protein Levels through cGMP-dependent Kinase (cGK)-Iα Causes Insulin Resistance in 3T3-L1 Adipocytes

(2015) Yasutoshi Ando et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

(2015) Giulia Milan et al.   Nature Communications

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity

(2015) Toshiaki Fukushima et al.   Nature Communications

Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes

(2015) Roberto Villaseñor et al.   eLife

The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins

(2015) Fumihiko Hakuno et al.   Frontiers in Endocrinology

Cell adhesion defines the topology of endocytosis and signaling

(2014) Jean-Philippe Grossier et al.   EMBO JOURNAL

Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin

(2014) L. Weng et al.   EMBO JOURNAL

How IGF-1 activates its receptor

(2014) Jennifer M Kavran et al.   eLife

The AP-1 Complex Regulates Intracellular Localization of Insulin Receptor Substrate 1, Which Is Required for Insulin-Like Growth Factor I-Dependent Cell Proliferation

(2013) Y. Yoneyama et al.   MOLECULAR AND CELLULAR BIOLOGY

Nexilin, a Cardiomyopathy-Associated F-Actin Binding Protein, Binds and Regulates IRS1 Signaling in Skeletal Muscle Cells

(2013) Andrew Lee et al.   PLoS One

Endocytosis of Receptor Tyrosine Kinases

(2013) L. K. Goh et al.   Cold Spring Harbor Perspectives in Biology

Cargo Recognition in Clathrin-Mediated Endocytosis

(2013) L. M. Traub et al.   Cold Spring Harbor Perspectives in Biology

Phosphatidylinositol 3-Kinase (PI3K) Activity Bound to Insulin-like Growth Factor-I (IGF-I) Receptor, which Is Continuously Sustained by IGF-I Stimulation, Is Required for IGF-I-induced Cell Proliferation

(2012) Toshiaki Fukushima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin and Insulin-like Growth Factor II Differentially Regulate Endocytic Sorting and Stability of Insulin Receptor Isoform A

(2012) Alaide Morcavallo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway

(2012) Hiroyuki Kubota et al.   MOLECULAR CELL

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor

(2012) H. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Basis of Signaling Specificity of Insulin and IGF Receptors: Neglected Corners and Recent Advances

(2012) Kenneth Siddle   Frontiers in Endocrinology

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A practical guide to evaluating colocalization in biological microscopy

(2011) Kenneth W. Dunn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The SCF-Fbxo40 Complex Induces IRS1 Ubiquitination in Skeletal Muscle, Limiting IGF1 Signaling

(2011) Jun Shi et al.   DEVELOPMENTAL CELL

Polyubiquitination of Insulin-like Growth Factor I Receptor (IGF-IR) Activation Loop Promotes Antibody-induced Receptor Internalization and Down-regulation

(2011) Yifan Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IGF1R Signaling in Ewing Sarcoma Is Shaped by Clathrin-/Caveolin-Dependent Endocytosis

(2011) Ana Sofia Martins et al.   PLoS One

Constitutive Expression of Insulin Receptor Substrate (IRS)-1 Inhibits Myogenic Differentiation through Nuclear Exclusion of Foxo1 in L6 Myoblasts

(2011) Fumihiko Hakuno et al.   PLoS One

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases

(2010) Toshiaki Fukushima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endocytic trafficking of activated EGFR is AP-2 dependent and occurs through preformed clathrin spots

(2009) J. Z. Rappoport et al.   JOURNAL OF CELL SCIENCE

The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development

(2008) Annette Schenck et al.   CELL

Clathrin-Mediated Internalization Is Essential for Sustained EGFR Signaling but Dispensable for Degradation

(2008) Sara Sigismund et al.   DEVELOPMENTAL CELL

Insulin-like growth factor I (IGF-I) is a more potent regulator of gene expression than insulin in primary human myoblasts and myotubes

(2008) Jane Palsgaard et al.   GROWTH HORMONE & IGF RESEARCH

Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization

(2008) Giada Monami et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor  2 subunit

(2008) J. T. Kittler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA