Article
Medicine, Research & Experimental
Farah Gulzar, Shadab Ahmad, Sushmita Singh, Pawan Kumar, Aditya Sharma, Akhilesh K. Tamrakar
Summary: This study demonstrates that activation of NOD1 in adipocytes can affect lipid metabolism in hepatocytes by promoting lipolysis and inflammatory responses. This effect is associated with enhanced transport of fatty acids and increased triglyceride synthesis rate in hepatocytes. Additionally, NOD1 activation induces inflammatory response and impairs insulin signaling in hepatocytes.
Article
Biochemistry & Molecular Biology
Francisco Diaz-Saez, Carla Blanco-Sinfreu, Adria Archilla-Ortega, David Sebastian, Montserrat Romero, Maria Isabel Hernandez-Alvarez, Silvia Mora, Xavier Testar, Wifredo Ricart, Jose Manuel Fernandez-Real, Jose Maria Moreno-Navarrete, Julian Aragones, Marta Camps, Antonio Zorzano, Anna Guma
Summary: The downregulation of Nrg4 in adipocytes impairs insulin action, likely due to decreased insulin receptor and Glut4 proteins, while also increasing proinflammatory cytokine expression and upregulating proteins involved in autophagy. Restoring lysosomal activity can partially reverse these effects, indicating that Nrg4 plays a role in maintaining insulin responsiveness and regulating autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jennifer L. Bailey, Hardy Hang, Anik Boudreau, Carrie M. Elks
Summary: The study found that OSM induces adipocyte lipolysis via the p66Shc-ERK pathway, inhibiting the suppression of lipolysis by insulin, and inducing phosphorylation of inhibitory IRS1 residues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Su Bu, Anran Xiong, Zhiying Yang, Faycal Aissa-Brahim, Ying Chen, Yichun Zhang, Xunyong Zhou, Fuliang Cao
Summary: Bilobalide exhibits beneficial bioactivities such as neuroprotection, anti-inflammation, and antioxidant effects. The study demonstrates that bilobalide can induce apoptosis in mature adipocytes through the ROS-mediated mitochondrial pathway.
Article
Nutrition & Dietetics
Malgorzata Malodobra-Mazur, Dominika Lewon, Aneta Cierzniak, Marta Okulus, Anna Gliszczynska
Summary: The study demonstrated the beneficial effects of cinnamic acid and 3-methoxycinnamic acid on insulin action. Furthermore, the phospholipid derivatives 1,2-dicinnamoyl-sn-glycero-3-phosphocholine and 1-cinnamoyl-2-palmitoyl-sn-glycero-3-phosphocholine showed even stronger improvement in insulin sensitivity in insulin-resistant adipocytes, providing more benefits.
Article
Cell Biology
Vanessa Castelli, Laura Brandolini, Michele D'Angelo, Cristina Giorgio, Margherita Alfonsetti, Pasquale Cocchiaro, Francesca Lombardi, Annamaria Cimini, Marcello Allegretti
Summary: Type 2 diabetes mellitus is a severe public health issue worldwide, often correlated with obesity. New drugs targeting the inhibition of proinflammatory adipocytokines secretion from adipocytes may be a potential treatment approach for the disease.
Article
Biochemistry & Molecular Biology
Pere Bibiloni, Catalina A. Pomar, Andreu Palou, Juana Sanchez, Francisca Serra
Summary: Elevated miR-222 levels are linked to metabolic syndrome, insulin resistance, and diabetes. Rats fed an obesogenic diet during lactation have higher miR-222 content in breast milk, leading to increased body fat mass and impaired insulin sensitivity in their offspring. Transfection experiments with miR-222 mimics or inhibitors on 3T3-L1 preadipocytes reveal that miR-222 plays a role in pathways related to insulin signaling, lipid metabolism, and adipogenesis.
Article
Pharmacology & Pharmacy
Eunji Kang, Jea Eun Park, Ji Sook Han
Summary: A study found that HM-chromanone extracted from Portulaca oleracea can inhibit inflammation and insulin resistance caused by obesity. In addition, HM-chromanone also improves inflammation and insulin resistance by regulating JNK activation and the NF-kappa B pathway, reducing inflammatory cytokine secretion, and inhibiting serine phosphorylation of IRS-1.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Beegum Noorjahan Shijina, Achuthan Radhika, Sainulabdeen Sherin, Prabath Gopalakrishnan Biju
Summary: The indole alkaloid vindoline from Catharanthus roseus was found to have significant improvements in insulin resistance, oxidative stress, and inflammatory responses. It enhanced glucose metabolism and increased the expression of insulin receptors, alleviating symptoms of insulin resistance.
Article
Biotechnology & Applied Microbiology
Eleanor H. Oates, Maciek R. Antoniewicz
Summary: Hypoxia has a significant impact on the physiology and metabolism of adipocytes, leading to the suppression of adipogenesis, de novo lipogenesis, and metabolic reprogramming. It alters the patterns of cellular metabolism, redirects glucose metabolism, rewires glutamine metabolism, suppresses branched chain amino acid consumption, and reduces the biosynthesis of certain fatty acids.
METABOLIC ENGINEERING
(2023)
Article
Nutrition & Dietetics
Jinfeng Wei, Baoguang Wang, Yixiao Chen, Qiuyi Wang, Adel F. Ahmed, Lili Cui, Xuefeng Xi, Wenyi Kang
Summary: This study found that two triterpenoids from N. sativa seeds inhibited insulin resistance and promoted insulin sensitivity, contributing to improved blood glucose control. These findings provide a basis for the potential application of N. sativa in medicine and functional foods.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Noura B. Younes, Omnia Ahmed Mohamed, Nasser M. Rizk
Summary: This study demonstrates that DHA has the potential to mitigate obesity by reducing the secretion of inflammatory adipokines, oxidative stress, lipolysis, and apoptosis in adipocytes exposed to low O-2 tension-induced hypoxia.
Article
Cell Biology
Hee-Hoon Kim, Young-Ri Shim, Ha Neul Kim, Keungmo Yang, Tom Ryu, Kyurae Kim, Sung Eun Choi, Min Jeong Kim, Chaerin Woo, Katherine Po Sin Chung, Song Hwa Hong, Hyemi Shin, Jae Myoung Suh, Youngae Jung, Geum-Sook Hwang, Won Kim, Seok-Hwan Kim, Hyuk Soo Eun, Je Kyung Seong, Won-Il Jeong
Summary: Obesity-induced hypoxic stress in white adipose tissue leads to inflammation and interferon-y (IFN-y) production by natural killer (NK) cells. This study reveals that hypoxia promotes glutamate excretion and CXCL12 expression in white adipocytes, recruiting CXCR4+ NK cells. The spatial proximity between adipocytes and NK cells induces IFN-y production by stimulating metabotropic glutamate receptor 5 (mGluR5), which triggers inflammatory activation of macrophages and increases xCT and CXCL12 expression in adipocytes. Inhibition of xCT, mGluR5, or IFN-y receptor in adipocytes or NK cells alleviates obesity-related metabolic disorders in mice and elevated glutamate/mGluR5 and CXCL12/CXCR4 levels are observed in obese patients, suggesting a potential therapeutic target for obesity-related metabolic disorders.
Article
Nutrition & Dietetics
Tomohiko Nakao, Shiro Otaki, Yuri Kominami, Soichi Watanabe, Miho Ito, Teruki Aizawa, Yusuke Akahori, Hideki Ushio
Summary: L-fucose (Fuc) demonstrates potent anti-obesity effects in mice, however, the underlying mechanisms are not fully understood. This study investigates the effects of Fuc on lipid metabolism and insulin signaling in 3T3-L1 adipocytes. Fuc treatment suppresses lipid accumulation and activates the AMPK pathway, responsible for regulating fatty acid oxidation and lipolysis. Fuc also promotes glucose uptake via Akt activation in an insulin-resistant state. These findings provide insights into the mechanism of Fuc's anti-obesity effects and its potential as a therapeutic compound.
Article
Medicine, Research & Experimental
Benjarat Janson, Janjira Prasomthong, Wachirawadee Malakul, Tantip Boonsong, Sakara Tunsophon
Summary: This study demonstrated that roselle extract can reduce body weight, food intake, lipid profiles, inflammatory cytokines, lipid peroxidation, serum leptin, insulin, and duodenal glucose absorption, while significantly increasing glucose uptake of adipose tissue and muscle compared to a high-fat diet group. Roselle can prevent lipid accumulation by suppressing differentiation of 3T3-L1 adipocyte through downregulating adipogenic gene expression, providing an alternative approach for preventing obesity-related insulin resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Preetha M. R. Rani, Anupama Nair, Sreelekshmi Mohan, K. G. Raghu
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Chemistry, Applied
P. Salin Raj, A. Prathapan, Jomon Sebastian, Antu K. Antony, Mariam Philip Riya, M. R. Preetha Rani, H. Biju, S. Priya, K. G. Raghu
NATURAL PRODUCT RESEARCH
(2014)
Article
Chemistry, Applied
K. R. Ajish, K. A. Antu, M. P. Riya, M. R. Preetharani, K. G. Raghu, B. P. Dhanya, K. V. Radhakrishnan
NATURAL PRODUCT RESEARCH
(2015)
Article
Toxicology
Nair Anupama, Preetha M. R. Rani, G. L. Shyni, K. G. Raghu
TOXICOLOGY IN VITRO
(2018)
Review
Pharmacology & Pharmacy
Sreelekshmi Mohan, Preetha M. R. Rani, Lindsay Brown, Prathapan Ayyappan, K. G. Raghu
EUROPEAN JOURNAL OF PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
M. R. Preetha Rani, P. Salin Raj, Anupama Nair, S. Ranjith, K. Rajankutty, K. G. Raghu
Summary: This study investigated the role of endoplasmic reticulum stress and its related pathways in diabetic cardiomyopathy, and found that endoplasmic reticulum stress plays a crucial role in the progression of the disease. Furthermore, chlorogenic acid was found to be beneficial against the pathological alterations caused by high glucose.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Anupama Nair, M. R. Preetha Rani, Palayyan Salin Raj, S. Ranjit, K. Rajankutty, K. G. Raghu
Summary: Diabetic cardiomyopathy (DCM) is a serious issue related to diabetes, and there is a lack of effective control and management strategies. Cinnamic acid has been shown to prevent DCM development through its cardioprotective, anti-inflammatory, anti-dyslipidemia potential, and antidiabetic properties.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
