More Than a Pore: The Cellular Response to Cholesterol-Dependent Cytolysins

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

(2013) J. A. Lopez et al.   BLOOD

Effects of MACPF/CDC proteins on lipid membranes

(2012) Robert J. C. Gilbert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Activation of the unfolded protein response by Listeria monocytogenes

(2012) Helena Pillich et al.   CELLULAR MICROBIOLOGY

Listeria monocytogenes-Derived Listeriolysin O Has Pathogen-Associated Molecular Pattern-Like Properties Independent of Its Hemolytic Ability

(2012) Anu Wallecha et al.   Clinical and Vaccine Immunology

Golgi Membrane Dynamics and Lipid Metabolism

(2012) Vytas A. Bankaitis et al.   CURRENT BIOLOGY

Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins

(2012) Michelle A Dunstone et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Role for Telomerase in Listeria monocytogenes Infection

(2012) Ascel Samba-Louaka et al.   INFECTION AND IMMUNITY

Association of Shiga toxin glycosphingolipid receptors with membrane microdomains of toxin-sensitive lymphoid and myeloid cells

(2012) Ivan U. Kouzel et al.   JOURNAL OF LIPID RESEARCH

Listeriolysin O Is Strongly Immunogenic Independently of Its Cytotoxic Activity

(2012) Javier A. Carrero et al.   PLoS One

The Cholesterol-Dependent Cytolysin Signature Motif: A Critical Element in the Allosteric Pathway that Couples Membrane Binding to Pore Assembly

(2012) Kelley J. Dowd et al.   PLoS Pathogens

The Pore-Forming Toxin β hemolysin/cytolysin Triggers p38 MAPK-Dependent IL-10 Production in Macrophages and Inhibits Innate Immunity

(2012) Magali Bebien et al.   PLoS Pathogens

Membrane Damage during Listeria monocytogenes Infection Triggers a Caspase-7 Dependent Cytoprotective Response

(2012) Sara K. B. Cassidy et al.   PLoS Pathogens

Membrane assembly of the cholesterol-dependent cytolysin pore complex

(2011) Eileen M. Hotze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Acid sphingomyelinase in macrophage biology

(2011) Jean-Philip Truman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pore-forming toxins induce multiple cellular responses promoting survival

(2011) Manuel R. Gonzalez et al.   CELLULAR MICROBIOLOGY

Macrophage responses to bacterial toxins: a balance between activation and suppression

(2011) Peter A. Keyel et al.   IMMUNOLOGIC RESEARCH

K+Efflux Is Required for Histone H3 Dephosphorylation by Listeria monocytogenes Listeriolysin O and Other Pore-Forming Toxins

(2011) Mélanie Anne Hamon et al.   INFECTION AND IMMUNITY

Streptolysin O clearance through sequestration into blebs that bud passively from the plasma membrane

(2011) P. A. Keyel et al.   JOURNAL OF CELL SCIENCE

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

(2011) Jerome Thiery et al.   NATURE IMMUNOLOGY

Listeria monocytogenestransiently alters mitochondrial dynamics during infection

(2011) Fabrizia Stavru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxin Pores Endocytosed During Plasma Membrane Repair Traffic into the Lumen of MVBs for Degradation

(2011) Matthias Corrotte et al.   TRAFFIC

Streptolysin O Inhibits Clathrin-Dependent Internalization of Group A Streptococcus

(2011) L. K. Logsdon et al.   mBio

Perfringolysin O Association with Ordered Lipid Domains: Implications for Transmembrane Protein Raft Affinity

(2010) Lindsay D. Nelson et al.   BIOPHYSICAL JOURNAL

Blebbing confers resistance against cell lysis

(2010) E B Babiychuk et al.   CELL DEATH AND DIFFERENTIATION

Streptococcus pyogenes cytolysin-mediated translocation does not require pore formation by streptolysin O

(2010) N'Goundo Magassa et al.   EMBO REPORTS

Specific Behavior of IntracellularStreptococcus pyogenesThat Has Undergone Autophagic Degradation Is Associated with Bacterial Streptolysin O and Host Small G Proteins Rab5 and Rab7

(2010) Atsuo Sakurai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair

(2010) Christina Tam et al.   JOURNAL OF CELL BIOLOGY

Listeria monocytogenesInduces T Cell Receptor Unresponsiveness through Pore‐Forming Toxin Listeriolysin O

(2010) Nelson O. Gekara et al.   JOURNAL OF INFECTIOUS DISEASES

Technical Advance: caspase-1 activation and IL-1β release correlate with the degree of lysosome damage, as illustrated by a novel imaging method to quantify phagolysosome damage

(2010) Michael J. Davis et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pneumolysin-induced CXCL8 production by nasopharyngeal epithelial cells is dependent on calcium flux and MAPK activation via Toll-like receptor 4

(2010) Semih Dogan et al.   MICROBES AND INFECTION

Listeriolysin O Is Necessary and Sufficient to Induce Autophagy during Listeria monocytogenes Infection

(2010) Nicole Meyer-Morse et al.   PLoS One

Crystal structure of cytotoxin protein suilysin from Streptococcus suis

(2010) Lingfeng Xu et al.   Protein & Cell

Cholesterol Exposure at the Membrane Surface Is Necessary and Sufficient to Trigger Perfringolysin O Binding

(2009) John J. Flanagan et al.   BIOCHEMISTRY

Cellular Functions and X-ray Structure of Anthrolysin O, a Cholesterol-dependent Cytolysin Secreted byBacillus anthracis

(2009) Raymond W. Bourdeau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF- B Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor

(2009) J. Harder et al.   JOURNAL OF IMMUNOLOGY

Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner

(2009) Jessica Chu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair

(2009) Maziar Divangahi et al.   NATURE IMMUNOLOGY

Streptococcus pyogenesinduces oncosis in macrophages through the activation of an inflammatory programmed cell death pathway

(2008) Oliver Goldmann et al.   CELLULAR MICROBIOLOGY

Functional and Phylogenetic Characterization of Vaginolysin, the Human-Specific Cytolysin from Gardnerella vaginalis

(2008) S. E. Gelber et al.   JOURNAL OF BACTERIOLOGY

Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis

(2008) Vincent Idone et al.   JOURNAL OF CELL BIOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blebs lead the way: how to migrate without lamellipodia

(2008) Guillaume Charras et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rapid Membrane Disruption by a Perforin-Like Protein Facilitates Parasite Exit from Host Cells

(2008) B. F. C. Kafsack et al.   SCIENCE

Activation of the Unfolded Protein Response Is Required for Defenses against Bacterial Pore-Forming Toxin In Vivo

(2008) Larry J. Bischof et al.   PLoS Pathogens