Effects of MACPF/CDC proteins on lipid membranes

Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins

(2012) Michelle A Dunstone et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC)

(2012) Alexander E. Aleshin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of C5b-6 Suggests Structural Basis for Priming Assembly of the Membrane Attack Complex

(2012) Alexander E. Aleshin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of Lysenin Reveal a Shared Evolutionary Origin for Pore-Forming Proteins And Its Mode of Sphingomyelin Recognition

(2012) Luigi De Colibus et al.   STRUCTURE

Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5b6 and sC5b9

(2012) Michael A. Hadders et al.   Cell Reports

Membrane assembly of the cholesterol-dependent cytolysin pore complex

(2011) Eileen M. Hotze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Intercellular communication via the endo-lysosomal system: Translocation of granzymes through membrane barriers

(2011) Sarah E. Stewart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

pH dependence of listeriolysin O aggregation and pore-forming ability

(2011) Andrej Bavdek et al.   FEBS Journal

Structure of Human C8 Protein Provides Mechanistic Insight into Membrane Pore Formation by Complement

(2011) Leslie L. Lovelace et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

(2011) Jerome Thiery et al.   NATURE IMMUNOLOGY

The Pfam protein families database

(2011) M. Punta et al.   NUCLEIC ACIDS RESEARCH

Perforin Rapidly Induces Plasma Membrane Phospholipid Flip-Flop

(2011) Sunil S. Metkar et al.   PLoS One

Perforin activity at membranes leads to invaginations and vesicle formation

(2011) T. Praper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the octameric pore of staphylococcal  -hemolysin reveals the  -barrel pore formation mechanism by two components

(2011) K. Yamashita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the Evolution of a Complex Virus from the Crystal Structure of Vaccinia Virus D13

(2011) Mohammad W. Bahar et al.   STRUCTURE

Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiontBacteroides thetaiotaomicron

(2010) Qingping Xu et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Human Perforin Employs Different Avenues to Damage Membranes

(2010) Tilen Praper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol microcrystals and cochleate cylinders: Attachment of pyolysin oligomers and domain 4

(2010) J. Robin Harris et al.   JOURNAL OF STRUCTURAL BIOLOGY

Human perforin permeabilizing activity, but not binding to lipid membranes, is affected by pH

(2010) Tilen Praper et al.   MOLECULAR IMMUNOLOGY

The structural basis for membrane binding and pore formation by lymphocyte perforin

(2010) Ruby H. P. Law et al.   NATURE

Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface

(2010) A. J. Farrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis

(2009) J. Thiery et al.   BLOOD

How baculovirus polyhedra fit square pegs into round holes to robustly package viruses

(2009) Xiaoyun Ji et al.   EMBO JOURNAL

The Molecular Basis for Perforin Oligomerization and Transmembrane Pore Assembly

(2009) Katherine Baran et al.   IMMUNITY

Complete genome sequence and taxonomic position of anguillid herpesvirus 1

(2009) S. J. van Beurden et al.   JOURNAL OF GENERAL VIROLOGY

The structure of a cytolytic α-helical toxin pore reveals its assembly mechanism

(2009) Marcus Mueller et al.   NATURE

Membrane scission by the ESCRT-III complex

(2009) Thomas Wollert et al.   NATURE

Pneumolysin generates multiple conductance pores in the membrane of nucleated cells

(2008) Rana G. El-Rachkidy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of a Streptococcal Cholesterol-Dependent Cytolysin with a Lewis y and b Specific Lectin Domain†

(2008) Stephen Farrand et al.   BIOCHEMISTRY

Host Cell Traversal Is Important for Progression of the Malaria Parasite through the Dermis to the Liver

(2008) Rogerio Amino et al.   Cell Host & Microbe

The MACPF/CDC family of pore-forming toxins

(2008) Carlos J. Rosado et al.   CELLULAR MICROBIOLOGY

Demonstration of a cholesterol-dependent cytolysin in a noninsecticidalBacillus sphaericusstrain and evidence for widespread distribution of the toxin within the species

(2008) Cecilie From et al.   FEMS MICROBIOLOGY LETTERS

Genomic analysis of the immune gene repertoire of amphioxus reveals extraordinary innate complexity and diversity

(2008) S. Huang et al.   GENOME RESEARCH

Crystal Structure of the MACPF Domain of Human Complement Protein C8α in Complex with the C8γ Subunit

(2008) Daniel J. Slade et al.   JOURNAL OF MOLECULAR BIOLOGY

Reverse genetics screen identifies six proteins important for malaria development in the mosquito

(2008) Andrea Ecker et al.   MOLECULAR MICROBIOLOGY

Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles

(2008) Cheryl L. Birmingham et al.   NATURE

Conformational transition of Sec machinery inferred from bacterial SecYE structures

(2008) Tomoya Tsukazaki et al.   NATURE

Structure of transmembrane pore induced by Bax-derived peptide: Evidence for lipidic pores

(2008) S. Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid Membrane Disruption by a Perforin-Like Protein Facilitates Parasite Exit from Host Cells

(2008) B. F. C. Kafsack et al.   SCIENCE

Migration of Apicomplexa Across Biological Barriers: The Toxoplasma and Plasmodium Rides

(2008) Isabelle Tardieux et al.   TRAFFIC

Disparate proteins use similar architectures to damage membranes

(2008) Gregor Anderluh et al.   TRENDS IN BIOCHEMICAL SCIENCES

Friend or foe: the same fold for attack and defense

(2008) Natalya Lukoyanova et al.   TRENDS IN IMMUNOLOGY

Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

(2008) Stephen C. Graham et al.   PLoS Pathogens