Concise Review: Ex Vivo Expansion of Cord Blood-Derived Hematopoietic Stem and Progenitor Cells: Basic Principles, Experimental Approaches, and Impact in Regenerative Medicine

Hematopoietic stem cells are pluripotent and not just “hematopoietic”

(2013) Makio Ogawa et al.   BLOOD CELLS MOLECULES AND DISEASES

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Engineering Stem Cell Expansion

(2012) Irwin D. Bernstein et al.   Cell Stem Cell

Rapid Expansion of Human Hematopoietic Stem Cells by Automated Control of Inhibitory Feedback Signaling

(2012) Elizabeth Csaszar et al.   Cell Stem Cell

Cord-Blood Engraftment with Ex Vivo Mesenchymal-Cell Coculture

(2012) Marcos de Lima et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc

(2012) A. Giorgetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and Inducibility of Cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in Human Cord Blood CD34+ Stem Cell–Derived Differentiating Neuronal Cells

(2012) Abhishek K. Singh et al.   TOXICOLOGICAL SCIENCES

Comparative in vitro analysis of different hematopoietic cell populations from human cord blood: in search of the best option for clinically oriented ex vivo cell expansion

(2012) Patricia Flores-Guzman et al.   TRANSFUSION

Umbilical Cord Blood: Lessons Learned and Lingering Challenges After More Than 20 Years of Basic and Clinical Research

(2011) Hector Mayani   ARCHIVES OF MEDICAL RESEARCH

Effects of extracellular matrix proteins on the growth of haematopoietic progenitor cells

(2011) Betül Çelebi et al.   Biomedical Materials

Ex vivo expansion of human hematopoietic stem and progenitor cells

(2011) A. Dahlberg et al.   BLOOD

SALL4 is a robust stimulator for the expansion of hematopoietic stem cells

(2011) J. R. Aguila et al.   BLOOD

In vitro effects of stromal cells expressing different levels of Jagged-1 and Delta-1 on the growth of primitive and intermediate CD34+ cell subsets from human cord blood

(2011) Verónica Fernández-Sánchez et al.   BLOOD CELLS MOLECULES AND DISEASES

Initial CD34+ cell-enrichment of cord blood determines hematopoietic stem/progenitor cell yield upon Ex vivo expansion

(2011) Pedro Z. Andrade et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment

(2011) F. Notta et al.   SCIENCE

Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells

(2011) Takashi Nagasawa et al.   TRENDS IN IMMUNOLOGY

Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts

(2010) S. Avery et al.   BLOOD

Combination of HOXB4 and Delta-1 ligand improves expansion of cord blood cells

(2010) K. L. Watts et al.   BLOOD

Mimicking the haematopoietic niche microenvironment provides a novel strategy for expansion of haematopoietic and megakaryocyte-progenitor cells from cord blood

(2010) Varda Deutsch et al.   BRITISH JOURNAL OF HAEMATOLOGY

Overcoming the barriers to umbilical cord blood transplantation

(2010) Susan Staba Kelly et al.   CYTOTHERAPY

Biology of the hemopoietic microenvironment

(2010) Hector Mayani et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Hematopoietic stem cell origin of connective tissues

(2010) Makio Ogawa et al.   EXPERIMENTAL HEMATOLOGY

Enabling stem cell therapies through synthetic stem cell–niche engineering

(2010) Raheem Peerani et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution

(2010) Colleen Delaney et al.   NATURE MEDICINE

Notch signaling: from stem cell expansion to improving cord blood transplantation

(2010) Hector Mayani   Expert Review of Hematology

Double Cord Blood Transplantation (CBT) With Ex-Vivo Expansion (EXP) of One Unit Utilizing A Mesenchymal Stromal Cell (MSC) Platform

(2009) M. de Lima et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Single-unit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8+ T-cell response against the nonengrafted unit

(2009) J. A. Gutman et al.   BLOOD

Generation of Induced Pluripotent Stem Cells from Human Cord Blood Using OCT4 and SOX2

(2009) Alessandra Giorgetti et al.   Cell Stem Cell

Individual and combined effects of mesenchymal stromal cells and recombinant stimulatory cytokines on the in vitro growth of primitive hematopoietic cells from human umbilical cord blood

(2009) Patricia Flores-Guzmán et al.   CYTOTHERAPY

Cell–cell interaction networks regulate blood stem and progenitor cell fate

(2009) Daniel C Kirouac et al.   Molecular Systems Biology

Biological Differences Between Neonatal and Adult Human Hematopoietic Stem/Progenitor Cells

(2009) Hector Mayani   STEM CELLS AND DEVELOPMENT

A Simplified Procedure for Hematopoietic Stem Cell Amplification Using a Serum-Free, Feeder Cell-Free Culture System

(2008) Ian M. Rogers et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Hematopoietic cytokines

(2008) D. Metcalf   BLOOD

Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial

(2008) M de Lima et al.   BONE MARROW TRANSPLANTATION

Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life

(2008) Sean J. Morrison et al.   CELL

Functional analysis of myelodysplastic syndromes-derived mesenchymal stem cells

(2008) Eugenia Flores-Figueroa et al.   LEUKEMIA RESEARCH