期刊
BLOOD CELLS MOLECULES AND DISEASES
卷 51, 期 1, 页码 3-8出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2013.01.008
关键词
Hematopoietic stem cell; Stem cell plasticity; Pluripotent stem cell; Tissue regeneration
类别
资金
- Biomedical Laboratory Research and Development Program of the Department of Veterans Affairs
- National Institutes of Health [R01 CA148772, K01 AR059097]
Over a decade ago, several preclinical transplantation studies suggested the striking concept of the tissue-reconstituting ability (often referred to as HSC plasticity) of hematopoietic stem cells (HSCs). While this heralded an exciting time of radically new therapies for disorders of many organs and tissues, the concept was soon mired in controversy and remained dormant for almost a decade. This commentary provides a concise review of evidence for HSC plasticity, including more recent findings based on single HSC transplantation in mouse and clinical transplantation studies. There is strong evidence for the concept that HSCs are pluripotent and are the source for the majority, if not all, of the cell types in our body. Also discussed are some biological and experimental issues that need to be considered in the future investigation of HSC plasticity. (C) 2013 Elsevier Inc. All rights reserved.
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