Type I IFNs drive hematopoietic stem and progenitor cell collapse via impaired proliferation and increased RIPK1-dependent cell death during shock-like ehrlichial infection

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis

(2018) Palak Amin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study

(2017) Bing Wang et al.   Oncotarget

Distinct Kinase-Independent Role of RIPK3 in CD11c + Mononuclear Phagocytes in Cytokine-Induced Tissue Repair

(2017) Kenta Moriwaki et al.   Cell Reports

MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock

(2017) Muhamuda Kader et al.   PLoS Pathogens

RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection

(2017) Jeffrey Downey et al.   PLoS Pathogens

Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase

(2016) Mingqun Lin et al.   Autophagy

IFNα-mediated remodeling of endothelial cells in the bone marrow niche

(2016) Áine M. Prendergast et al.   HAEMATOLOGICA

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN

(2016) Diana Legarda et al.   Cell Reports

Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis

(2016) Jun-ichi Furusawa et al.   PLoS Pathogens

IFNα-mediated remodeling of endothelial cells in the bone marrow niche

(2016) Áine M. Prendergast et al.   HAEMATOLOGICA

Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88

(2016) Huajia Zhang et al.   Stem Cell Reports

Sepsis and septic shock

(2016) Richard S. Hotchkiss et al.   Nature Reviews Disease Primers

Type I Interferon Contributes to Noncanonical Inflammasome Activation, Mediates Immunopathology, and Impairs Protective Immunity during Fatal Infection with Lipopolysaccharide-Negative Ehrlichiae

(2015) Qin Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors

(2015) Simon Haas et al.   Cell Stem Cell

Comparative long-term effects of interferon α and hydroxyurea on human hematopoietic progenitor cells

(2015) Katherine Y. King et al.   EXPERIMENTAL HEMATOLOGY

A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing

(2015) Kenta Moriwaki et al.   JOURNAL OF IMMUNOLOGY

Tick-borne diseases of the USA: Ten things clinicians should know

(2015) Steven C. Buckingham   JOURNAL OF INFECTION

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Macrophage-Lineage Cells Negatively Regulate the Hematopoietic Stem Cell Pool in Response to Interferon Gamma at Steady State and During Infection

(2015) Amanda McCabe et al.   STEM CELLS

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Type I Interferons Promote Severe Disease in a Mouse Model of Lethal Ehrlichiosis

(2014) Yubin Zhang et al.   INFECTION AND IMMUNITY

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons

(2014) Eric M. Pietras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New Function of Type I IFN: Induction of Autophagy

(2014) Hana Schmeisser et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages

(2014) S. McComb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmed necrosis in microbial pathogenesis

(2014) Haripriya Sridharan et al.   TRENDS IN MICROBIOLOGY

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

(2014) Q Remijsen et al.   Cell Death & Disease

Staphylococcus aureus recognition by hematopoietic stem and progenitor cells via TLR2/MyD88/PGE2 stimulates granulopoiesis in wounds

(2013) J. L. Granick et al.   BLOOD

Interferon-  impairs proliferation of hematopoietic stem cells in mice

(2013) A. M. de Bruin et al.   BLOOD

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

(2013) Y Dondelinger et al.   CELL DEATH AND DIFFERENTIATION

The c-FLIPLCleavage Product p43FLIP Promotes Activation of Extracellular Signal-regulated Kinase (ERK), Nuclear Factor κB (NF-κB), and Caspase-8 and T Cell Survival

(2013) Andreas Koenig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MyD88 Signaling in CD4 T Cells Promotes IFN-  Production and Hematopoietic Progenitor Cell Expansion in Response to Intracellular Bacterial Infection

(2013) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

TLR2 and Nod2 Mediate Resistance or Susceptibility to Fatal Intracellular Ehrlichia Infection in Murine Models of Ehrlichiosis

(2013) Partho Chattoraj et al.   PLoS One

Demand-adapted regulation of early hematopoiesis in infection and inflammation

(2012) H. Takizawa et al.   BLOOD

Immune Mediators of protective and pathogenic immune responses in patients with mild and fatal human monocytotropic ehrlichiosis

(2012) Nahed Ismail et al.   BMC IMMUNOLOGY

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

(2012) Nirmal Robinson et al.   NATURE IMMUNOLOGY

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands

(2011) Chao Shi et al.   IMMUNITY

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

The Interaction between IL-18 and IL-18 Receptor Limits the Magnitude of Protective Immunity and Enhances Pathogenic Responses following Infection with Intracellular Bacteria

(2011) P. Ghose et al.   JOURNAL OF IMMUNOLOGY

Prevention of Bone Marrow Cell Apoptosis and Regulation of Hematopoiesis by Type I IFNs during Systemic Responses to Pneumocystis Lung Infection

(2011) D. Taylor et al.   JOURNAL OF IMMUNOLOGY

Transient Activation of Hematopoietic Stem and Progenitor Cells by IFNγ during Acute Bacterial Infection

(2011) Katherine C. MacNamara et al.   PLoS One

Natural Killer Cells Promote Tissue Injury and Systemic Inflammatory Responses During Fatal Ehrlichia-Induced Toxic Shock-Like Syndrome

(2010) Heather L. Stevenson et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagic degradation of active caspase-8

(2010) Wen Hou et al.   Autophagy

Cutting Edge: Bacterial Infection Induces Hematopoietic Stem and Progenitor Cell Expansion in the Absence of TLR Signaling

(2010) Philip O. Scumpia et al.   JOURNAL OF IMMUNOLOGY

FADD Deficiency Impairs Early Hematopoiesis in the Bone Marrow

(2010) S. Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Infection-Induced Myelopoiesis during Intracellular Bacterial Infection Is Critically Dependent upon IFN-  Signaling

(2010) K. C. MacNamara et al.   JOURNAL OF IMMUNOLOGY

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

Ixodes ovatus Ehrlichia Exhibits Unique Ultrastructural Characteristics in Mammalian Endothelial and Tick-derived Cells

(2009) Ulrike G. Munderloh et al.   Annals of the New York Academy of Sciences

Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis

(2009) S. Rodriguez et al.   BLOOD

Type I interferon drives tumor necrosis factor–induced lethal shock

(2009) Liesbeth Huys et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Tumor necrosis factor-α and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation

(2008) Luis Fernandez et al.   EXPERIMENTAL HEMATOLOGY