Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS
出版年份 2015 全文链接
标题
Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS
作者
关键词
Experimental autoimmune encephalomyelitis, Multiple sclerosis, Microglia, Hydroxycarboxylic acid receptor 2, Synaptopathy, Neuroinflammation, Neuroprotection
出版物
ACTA NEUROPATHOLOGICA
Volume 130, Issue 2, Pages 279-295
出版商
Springer Nature
发表日期
2015-04-28
DOI
10.1007/s00401-015-1422-3
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis
- (2014) Nagendra Singh et al. IMMUNITY
- Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation
- (2014) Antonio Cuadrado et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE
- (2014) Hui Chen et al. JOURNAL OF CLINICAL INVESTIGATION
- The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages
- (2014) Mahbubur Rahman et al. Nature Communications
- Microglial calcium signaling in the adult, aged and diseased brain
- (2013) Bianca Brawek et al. CELL CALCIUM
- Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
- (2013) Anu Kauppinen et al. CELLULAR SIGNALLING
- Dimethyl Fumarate for Treatment of Multiple Sclerosis: Mechanism of Action, Effectiveness, and Side Effects
- (2013) Ralf A. Linker et al. Current Neurology and Neuroscience Reports
- The role of HCA2 (GPR109A) in regulating macrophage function
- (2013) Kambiz Zandi-Nejad et al. FASEB JOURNAL
- Can we switch microglia's phenotype to foster neuroprotection? Focus on multiple sclerosis
- (2013) Debora Giunti et al. IMMUNOLOGY
- Interleukin-1 Alters Glutamate Transmission at Purkinje Cell Synapses in a Mouse Model of Multiple Sclerosis
- (2013) G. Mandolesi et al. JOURNAL OF NEUROSCIENCE
- Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
- (2013) Yukihiro Furusawa et al. NATURE
- Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
- (2013) Nicholas Arpaia et al. NATURE
- Layer V cortical neurons require microglial support for survival during postnatal development
- (2013) Masaki Ueno et al. NATURE NEUROSCIENCE
- Anti-Inflammatory Effects of Nicotinic Acid in Human Monocytes Are Mediated by GPR109A Dependent Mechanisms
- (2012) Janet E. Digby et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling
- (2012) Haiyan Peng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TGFβ signalling plays an important role in IL4-induced alternative activation of microglia
- (2012) Xiaolai Zhou et al. Journal of Neuroinflammation
- G protein-coupled receptors for energy metabolites as new therapeutic targets
- (2012) Clara C. Blad et al. NATURE REVIEWS DRUG DISCOVERY
- Placebo-Controlled Phase 3 Study of Oral BG-12 or Glatiramer in Multiple Sclerosis
- (2012) Robert J. Fox et al. NEW ENGLAND JOURNAL OF MEDICINE
- Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis
- (2012) Ralf Gold et al. NEW ENGLAND JOURNAL OF MEDICINE
- Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
- (2011) Ralf A. Linker et al. BRAIN
- Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis
- (2011) Silvia Rossi et al. BRAIN BEHAVIOR AND IMMUNITY
- Fumaric acid and its esters: An emerging treatment for multiple sclerosis with antioxidative mechanism of action
- (2011) R. Gold et al. CLINICAL IMMUNOLOGY
- Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells
- (2011) Martina Lukasova et al. JOURNAL OF CLINICAL INVESTIGATION
- Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells
- (2011) Kamran Ghoreschi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease
- (2011) Shi Zhang et al. Journal of Neuroinflammation
- The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
- (2011) A. Menssen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Abnormal activity of the Na/Ca exchanger enhances glutamate transmission in experimental autoimmune encephalomyelitis
- (2010) Silvia Rossi et al. BRAIN BEHAVIOR AND IMMUNITY
- Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1
- (2010) Zhenggang Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nicotinic acid– and monomethyl fumarate–induced flushing involves GPR109A expressed by keratinocytes and COX-2–dependent prostanoid formation in mice
- (2010) Julien Hanson et al. JOURNAL OF CLINICAL INVESTIGATION
- IκBβ is an essential co-activator for LPS-induced IL-1β transcription in vivo
- (2010) Melanie Scheibel et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation
- (2010) Henrik Wilms et al. Journal of Neuroinflammation
- IκBβ acts to inhibit and activate gene expression during the inflammatory response
- (2010) Ping Rao et al. NATURE
- Dimethylfumarate inhibits NF-κB function at multiple levels to limit airway smooth muscle cell cytokine secretion
- (2009) P. Seidel et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death
- (2009) Kaoru Saijo et al. CELL
- Gene Transfer of Inducible Nitric Oxide Synthase Affords Cardioprotection by Upregulating Heme Oxygenase-1 Via a Nuclear Factor-κB-Dependent Pathway
- (2009) Qianhong Li et al. CIRCULATION
- A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia
- (2009) Christine L. Hsieh et al. JOURNAL OF NEUROCHEMISTRY
- Inflammation Triggers Synaptic Alteration and Degeneration in Experimental Autoimmune Encephalomyelitis
- (2009) D. Centonze et al. JOURNAL OF NEUROSCIENCE
- Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals
- (2009) H. Wake et al. JOURNAL OF NEUROSCIENCE
- PU.1 is regulated by NF-κB through a novel binding site in a 17 kb upstream enhancer element
- (2009) N Bonadies et al. ONCOGENE
- The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist
- (2008) Hua Tang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
- (2008) Marcella Fulco et al. DEVELOPMENTAL CELL
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