Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events

The GTPase ARF6 Controls ROS Production to Mediate Angiotensin II-Induced Vascular Smooth Muscle Cell Proliferation

(2016) Mohamed Bourmoum et al.   PLoS One

TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions

(2016) Xiaofeng Chen et al.   PLoS One

Hypertension overrides the protective effect of female hormones on the development of aortic aneurysm secondary to Alk5 deficiency via ERK activation

(2015) Bradley M. Schmit et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome

(2015) James W. Wisler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in MiceSignificance

(2015) Jie Hong Hu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dimorphic Effects of Transforming Growth Factor-β Signaling During Aortic Aneurysm Progression in Mice Suggest a Combinatorial Therapy for Marfan SyndromeSignificance

(2015) Jason R. Cook et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of Mechanotransduction in Vascular Biology: Focus on Thoracic Aortic Aneurysms and Dissections

(2015) J. D. Humphrey et al.   CIRCULATION RESEARCH

Mutations in a TGF-β Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections

(2015) Aida M. Bertoli-Avella et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Abnormal mechanosensing and cofilin activation promote the progression of ascending aortic aneurysms in mice

(2015) Yoshito Yamashiro et al.   Science Signaling

A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome

(2015) Jefferson J Doyle et al.   eLife

Abnormal mechanosensing and cofilin activation promote the progression of ascending aortic aneurysms in mice

(2015) Yoshito Yamashiro et al.   Science Signaling

A century old renin–angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology

(2014) Pitchai Balakumar et al.   CELLULAR SIGNALLING

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis

(2014) Wei Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome

(2014) Ronald V. Lacro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Smad2-Dependent Protease Nexin-1 Overexpression Differentiates Chronic Aneurysms From Acute Dissections of Human Ascending Aorta

(2013) Delphine Gomez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Aortic Remodeling After Transverse Aortic Constriction in Mice Is Attenuated With AT 1 Receptor Blockade

(2013) Shao-Qing Kuang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Modifications of Chromatin Dynamics Control Smad2 Pathway Activation in Aneurysmal Smooth Muscle Cells

(2013) Delphine Gomez et al.   CIRCULATION RESEARCH

Genetics of Thoracic Aortic Aneurysm

(2013) Elisabeth Gillis et al.   CIRCULATION RESEARCH

Multicenter Phase I Trial of the Mitogen-Activated Protein Kinase 1/2 Inhibitor BAY 86-9766 in Patients with Advanced Cancer

(2013) C. D. Weekes et al.   CLINICAL CANCER RESEARCH

TGFβ Signaling and Cardiovascular Diseases

(2013) Evangelia Pardali et al.   International Journal of Biological Sciences

Angiotensin II–dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis

(2013) Elena M. Gallo et al.   JOURNAL OF CLINICAL INVESTIGATION

Aortic aneurysms in Loeys-Dietz syndrome — a tale of two pathways?

(2013) Frank Davis et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiotensin-Converting Enzyme-Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin-4-Deficient Mice

(2013) J. Huang et al.   Science Translational Medicine

Monocyte Chemoattractant Protein-1/CCR2 Axis Promotes Vein Graft Neointimal Hyperplasia Through Its Signaling in Graft-Extrinsic Cell Populations

(2012) Chunhua Fu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Matrix-dependent perturbation of TGFβ signaling and disease

(2012) Jefferson J. Doyle et al.   FEBS LETTERS

Promiscuity and specificity in BMP receptor activation

(2012) Thomas D. Mueller et al.   FEBS LETTERS

The paradoxical TGF-β vasculopathies

(2012) Rosemary J. Akhurst   NATURE GENETICS

Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm

(2012) Mark E Lindsay et al.   NATURE GENETICS

TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome

(2012) Catherine Boileau et al.   NATURE GENETICS

Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm

(2012) Alexander J Doyle et al.   NATURE GENETICS

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transforming Growth Factor-β Signaling in Myogenic Cells Regulates Vascular Morphogenesis, Differentiation, and Matrix Synthesis

(2011) Mia Jaffe et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

miR-29b Participates in Early Aneurysm Development in Marfan Syndrome

(2011) Denis R. Merk et al.   CIRCULATION RESEARCH

Novel MYH11 and ACTA2 mutations reveal a role for enhanced TGFβ signaling in FTAAD

(2011) Marjolijn Renard et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Lessons on the pathogenesis of aneurysm from heritable conditions

(2011) Mark E. Lindsay et al.   NATURE

Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

(2011) Ingrid M B H van de Laar et al.   NATURE GENETICS

Noncanonical TGF  Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

(2011) T. M. Holm et al.   SCIENCE

Angiotensin II Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice Through ERK Antagonism

(2011) J. P. Habashi et al.   SCIENCE

Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms

(2010) Delphine Gomez et al.   CARDIOVASCULAR RESEARCH

Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE−/−mice

(2010) Alan Daugherty et al.   CLINICAL SCIENCE

Quantitative analysis of TGFBR2 mutations in Marfan-syndrome-related disorders suggests a correlation between phenotypic severity and Smad signaling activity

(2010) D. Horbelt et al.   JOURNAL OF CELL SCIENCE

TGF-β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II–infused mice

(2010) Yu Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Conditional inactivation of TGF-β type II receptor in smooth muscle cells and epicardium causes lethal aortic and cardiac defects

(2010) Dominique Langlois et al.   TRANSGENIC RESEARCH

ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice

(2009) Lisa A. Cassis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer

(2009) C. Iverson et al.   CANCER RESEARCH

The regulation of TGF  signal transduction

(2009) A. Moustakas et al.   DEVELOPMENT

Analysis of multigenerational families with thoracic aortic aneurysms and dissections due to TGFBR1 or TGFBR2 mutations

(2009) V Tran-Fadulu et al.   JOURNAL OF MEDICAL GENETICS

Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway

(2009) Delphine Gomez et al.   JOURNAL OF PATHOLOGY