Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis

Rapamycin Inhibits Smooth Muscle Cell Proliferation and Obstructive Arteriopathy Attributable to Elastin Deficiency

(2013) Wei Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Everolimus Limits Aortic Aneurysm in the Apolipoprotein E–Deficient Mouse by Downregulating C-C Chemokine Receptor 2 Positive Monocytes

(2013) Corey S. Moran et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β

(2013) Christina L. Papke et al.   HUMAN MOLECULAR GENETICS

GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency

(2013) Ping Ye et al.   JOURNAL OF CLINICAL INVESTIGATION

Rare, Nonsynonymous Variant in the Smooth Muscle-Specific Isoform of Myosin Heavy Chain, MYH11 , R247C, Alters Force Generation in the Aorta and Phenotype of Smooth Muscle Cells

(2012) Shao-Qing Kuang et al.   CIRCULATION RESEARCH

Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice

(2012) Jun-ichi Iwata et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm

(2012) Mark E Lindsay et al.   NATURE GENETICS

TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome

(2012) Catherine Boileau et al.   NATURE GENETICS

Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm

(2012) Alexander J Doyle et al.   NATURE GENETICS

Transforming Growth Factor Beta Expression by Human Vascular Cells Inhibits Interferon Gamma Production and Arterial Media Injury by Alloreactive Memory T Cells

(2011) A. H. Lebastchi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Adventitia

(2011) Mark W. Majesky et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Activation of human vascular cells decreases their expression of transforming growth factor-beta

(2011) Amir H. Lebastchi et al.   ATHEROSCLEROSIS

Novel MYH11 and ACTA2 mutations reveal a role for enhanced TGFβ signaling in FTAAD

(2011) Marjolijn Renard et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Lessons on the pathogenesis of aneurysm from heritable conditions

(2011) Mark E. Lindsay et al.   NATURE

Long Term Stabilization of Expanding Aortic Aneurysms by a Short Course of Cyclosporine A through Transforming Growth Factor-Beta Induction

(2011) Jianping Dai et al.   PLoS One

Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning

(2011) K. A. Fakhro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noncanonical TGF  Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

(2011) T. M. Holm et al.   SCIENCE

Mutations in Myosin Light Chain Kinase Cause Familial Aortic Dissections

(2010) Li Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Role of myofibroblasts in vascular remodelling: focus on restenosis and aneurysm

(2010) A. Forte et al.   CARDIOVASCULAR RESEARCH

TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections

(2010) Sakiko Inamoto et al.   CARDIOVASCULAR RESEARCH

Gain or loss of TGF-β signaling in mammary carcinoma cells can promote metastasis

(2010) Brian Bierie et al.   CELL CYCLE

Genetic variants promoting smooth muscle cell proliferation can result in diffuse and diverse vascular diseases: Evidence for a hyperplastic vasculomyopathy

(2010) Dianna M Milewicz et al.   GENETICS IN MEDICINE

Thoracic aortic disease in tuberous sclerosis complex: molecular pathogenesis and potential therapies in Tsc2+/− mice

(2010) Jiumei Cao et al.   HUMAN MOLECULAR GENETICS

TGF-β in the pathogenesis and prevention of disease: a matter of aneurysmic proportions

(2010) Harry C. Dietz   JOURNAL OF CLINICAL INVESTIGATION

TGF-β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II–infused mice

(2010) Yu Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses

(2010) Jing Zhou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Signaling by members of the TGF-β family in vascular morphogenesis and disease

(2010) Evangelia Pardali et al.   TRENDS IN CELL BIOLOGY

Histopathologic Findings in Ascending Aortas From Individuals With Loeys-Dietz Syndrome (LDS)

(2009) Joseph J. Maleszewski et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

TGF-β1 Limits Plaque Growth, Stabilizes Plaque Structure, and Prevents Aortic Dilation in Apolipoprotein E-Null Mice

(2009) Andrew D. Frutkin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Absence of TGFβ signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm

(2009) Bibha Choudhary et al.   GENESIS

Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway

(2009) Delphine Gomez et al.   JOURNAL OF PATHOLOGY

Genetic Basis of Thoracic Aortic Aneurysms and Dissections: Focus on Smooth Muscle Cell Contractile Dysfunction

(2008) Dianna M. Milewicz et al.   Annual Review of Genomics and Human Genetics

p38 MAPK Is an Early Determinant of Promiscuous Smad2/3 Signaling in the Aortas of Fibrillin-1 (Fbn1)-null Mice

(2008) Luca Carta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries

(2008) Paul C.Y. Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transforming Growth Factor-β Signaling in Thoracic Aortic Aneurysm Development: A Paradox in Pathogenesis

(2008) Jeffrey A. Jones et al.   JOURNAL OF VASCULAR RESEARCH

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

(2008) Motozo Yamashita et al.   MOLECULAR CELL

Angiotensin II Blockade and Aortic-Root Dilation in Marfan's Syndrome

(2008) Benjamin S. Brooke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of TGF-  in proliferative vitreoretinal diseases and ROCK as a therapeutic target

(2008) T. Kita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA