Abnormal mechanosensing and cofilin activation promote the progression of ascending aortic aneurysms in mice

Role of Mechanotransduction in Vascular Biology: Focus on Thoracic Aortic Aneurysms and Dissections

(2015) J. D. Humphrey et al.   CIRCULATION RESEARCH

Insulin Receptor Substrate-4 Binds to Slingshot-1 Phosphatase and Promotes Cofilin Dephosphorylation

(2014) Yuta Homma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome

(2014) Ronald V. Lacro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections

(2013) Dong-chuan Guo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Aortic Remodeling After Transverse Aortic Constriction in Mice Is Attenuated With AT 1 Receptor Blockade

(2013) Shao-Qing Kuang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma

(2013) Elizabeth E. Gerber et al.   NATURE

Functions of cofilin in cell locomotion and invasion

(2013) Jose Javier Bravo-Cordero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PLC , PKD1, and SSH1L Transduce RhoA Signaling to Protect Mitochondria from Oxidative Stress in the Heart

(2013) S. Y. Xiang et al.   Science Signaling

Angiotensin-Converting Enzyme-Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin-4-Deficient Mice

(2013) J. Huang et al.   Science Translational Medicine

Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation

(2012) Kensaku Mizuno   CELLULAR SIGNALLING

Rare, Nonsynonymous Variant in the Smooth Muscle-Specific Isoform of Myosin Heavy Chain, MYH11 , R247C, Alters Force Generation in the Aorta and Phenotype of Smooth Muscle Cells

(2012) Shao-Qing Kuang et al.   CIRCULATION RESEARCH

Cloud CPFP: A Shotgun Proteomics Data Analysis Pipeline Using Cloud and High Performance Computing

(2012) David C. Trudgian et al.   JOURNAL OF PROTEOME RESEARCH

Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm

(2012) Alexander J Doyle et al.   NATURE GENETICS

Serum Response Factor (SRF)-cofilin-actin signaling axis modulates mitochondrial dynamics

(2012) H. Beck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased aortic diameter and compliance precedes blood pressure increases in postnatal development of elastin-insufficient mice

(2011) Victoria P. Le et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Slingshot Isoform-Specific Regulation of Cofilin-Mediated Vascular Smooth Muscle Cell Migration and Neointima Formation

(2011) Rebecca A. Torres et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Actin dynamics and turnover in cell motility

(2011) Klemens Rottner et al.   CURRENT OPINION IN CELL BIOLOGY

Phosphorylation of Ser 402 impedes phosphatase activity of slingshot 1

(2011) Sandra Barišić et al.   EMBO REPORTS

Actin filaments function as a tension sensor by tension-dependent binding of cofilin to the filament

(2011) Kimihide Hayakawa et al.   JOURNAL OF CELL BIOLOGY

Dynamic molecular processes mediate cellular mechanotransduction

(2011) Brenton D. Hoffman et al.   NATURE

Noncanonical TGF  Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

(2011) T. M. Holm et al.   SCIENCE

The importance of elastin to aortic development in mice

(2010) Jessica E. Wagenseil et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ectopic coexpression of keratin 8 and 18 promotes invasion of transformed keratinocytes and is induced in patients with cutaneous squamous cell carcinoma

(2010) Yoshito Yamashiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CPFP: a central proteomics facilities pipeline

(2010) D. C. Trudgian et al.   BIOINFORMATICS

TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections

(2010) Sakiko Inamoto et al.   CARDIOVASCULAR RESEARCH

Altered TGFβ signaling and cardiovascular manifestations in patients with autosomal recessive cutis laxa type I caused by fibulin-4 deficiency

(2010) Marjolijn Renard et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Transverse Aortic Constriction in Mice

(2010) Angela C. deAlmeida et al.   Jove-Journal of Visualized Experiments

Protein Kinase D Regulates Cell Migration by Direct Phosphorylation of the Cofilin Phosphatase Slingshot 1 Like

(2009) P. Peterburs et al.   CANCER RESEARCH

Phosphoinositide 3-kinase inhibitor (wortmannin) inhibits pancreatic cancer cell motility and migration induced by hyaluronanin vitroand peritoneal metastasisin vivo

(2009) Futoshi Teranishi et al.   CANCER SCIENCE

Fibulin-4 Deficiency Results in Ascending Aortic Aneurysms

(2009) Jianbin Huang et al.   CIRCULATION RESEARCH

Reactive Oxygen Species Regulate a Slingshot-Cofilin Activation Pathway

(2009) Jun-Sub Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot

(2009) Tim Eiseler et al.   NATURE CELL BIOLOGY

Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase

(2009) Masahito Horiguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Basis of Thoracic Aortic Aneurysms and Dissections: Focus on Smooth Muscle Cell Contractile Dysfunction

(2008) Dianna M. Milewicz et al.   Annual Review of Genomics and Human Genetics

Characterization of the bovine angiotensin converting enzyme promoter: Essential roles of Egr-1, ATF-2 and Ets-1 in the regulation by phorbol ester

(2008) Ognoon Mungunsukh et al.   GENE

Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse

(2008) Olivia Wendling et al.   GENESIS

Molecular Dissection of the Mechanisms of Substrate Recognition and F-actin-mediated Activation of Cofilin-phosphatase Slingshot-1

(2008) Souichi Kurita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Regulation of Cofilin Activity by LIM Kinase and Slingshot-1L Phosphatase Controls Platelet-Derived Growth Factor–Induced Migration of Human Aortic Smooth Muscle Cells

(2007) Alejandra San Martín et al.   CIRCULATION RESEARCH