Naturally occurring tetramic acid products: isolation, structure elucidation and biological activity

Total Synthesis and Absolute Configuration of Epicoccamide D, a Naturally Occurring Mannosylated 3-Acyltetramic Acid

(2013) Sebastian Loscher et al.   CHEMISTRY-A EUROPEAN JOURNAL

Epi-trichosetin, a new undecaprenyl pyrophosphate synthase inhibitor, produced by Fusarium oxysporum FKI-4553

(2013) Junji Inokoshi et al.   JOURNAL OF ANTIBIOTICS

Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J

(2013) Mostafa E Rateb et al.   JOURNAL OF ANTIBIOTICS

Studies on pyranonigrins–isolation of pyranonigrin E and biosynthetic studies on pyranonigrin A

(2013) Risa Riko et al.   JOURNAL OF ANTIBIOTICS

Peptaibols, Tetramic Acid Derivatives, Isocoumarins, and Sesquiterpenes from a Bionectria sp. (MSX 47401)

(2013) Mario Figueroa et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis of Penicillenol C1 and of a Bis-Azide Analogue for Photoaffinity Labeling

(2013) Karl Kempf et al.   JOURNAL OF ORGANIC CHEMISTRY

The novel equisetin-like compound, TA-289, causes aberrant mitochondrial morphology which is independent of the production of reactive oxygen species in Saccharomyces cerevisiae

(2013) Natelle C. H. Quek et al.   Molecular BioSystems

Cordylactam, a new alkaloid from the spider pathogenic fungus Cordyceps sp. BCC 12671

(2013) Masahiko Isaka et al.   Phytochemistry Letters

Total synthesis of virgineone aglycone and stereochemical assignment of natural virgineone

(2013) Arata Yajima et al.   TETRAHEDRON LETTERS

A photoisomerization-coupled asymmetric Stetter reaction: application to the total synthesis of three diastereomers of (−)-cephalimysin A

(2013) Stephen P. Lathrop et al.   Chemical Science

Biosynthesis of natural products by microbial iterative hybrid PKS–NRPS

(2013) Katja Maria Fisch   RSC Advances

Asymmetric Synthesis and Biosynthetic Implications of (+)-Fusarisetin A

(2012) Jun Yin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isolation and Characterization of Signermycin B, an Antibiotic That Targets the Dimerization Domain of Histidine Kinase WalK

(2012) Takafumi Watanabe et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities

(2012) Sheo B. Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular Diversity Sculpted by Fungal PKS-NRPS Hybrids

(2012) Daniela Boettger et al.   CHEMBIOCHEM

The Antimalarial Natural Product Symplostatin 4 Is a Nanomolar Inhibitor of the Food Vacuole Falcipains

(2012) Sara Christina Stolze et al.   CHEMISTRY & BIOLOGY

Amycolamicin: A Novel Broad-Spectrum Antibiotic Inhibiting Bacterial Topoisomerase

(2012) Ryuichi Sawa et al.   CHEMISTRY-A EUROPEAN JOURNAL

Isolation, Biological Activity Evaluation, Structure Elucidation, and Total Synthesis of Eliamid: A Novel Complex I Inhibitor

(2012) Gerhard Höfle et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Syntheses of Rigidiusculamides A and B: Revision of the Relative Stereochemistry of Rigidiusculamide A

(2012) Gui-Yang Chen et al.   Chemistry-An Asian Journal

Metabolite Profiling and Bioactivity of Rice Koji Fermented by Aspergillus Strains

(2012) Ah-Jin Kim   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Creation of an HDAC-Based Yeast Screening Method for Evaluation of Marine-Derived Actinomycetes: Discovery of Streptosetin A

(2012) Taro Amagata et al.   JOURNAL OF NATURAL PRODUCTS

Isolation, Structure Elucidation, and Antibacterial Activity of Methiosetin, a Tetramic Acid from a Tropical Sooty Mold (Capnodium sp.)

(2012) Kithsiri Herath et al.   JOURNAL OF NATURAL PRODUCTS

(+)-Ascosalitoxin and Vermelhotin, a Calmodulin Inhibitor, from an Endophytic Fungus Isolated from Hintonia latiflora

(2012) Martha Leyte-Lugo et al.   JOURNAL OF NATURAL PRODUCTS

Total Synthesis of (−)-Tirandamycin C Utilizing a Desymmetrization Protocol

(2012) J. S. Yadav et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis and Biological Activity of the Proposed Structure of Phaeosphaeride A

(2012) Anthoula Chatzimpaloglou et al.   JOURNAL OF ORGANIC CHEMISTRY

A Synthetic Approach to Diverse 3-Acyltetramic Acids via O- to C-Acyl Rearrangement and Application to the Total Synthesis of Penicillenol Series

(2012) Tetsuya Sengoku et al.   JOURNAL OF ORGANIC CHEMISTRY

Δ11,12 Double Bond Formation in Tirandamycin Biosynthesis is Atypically Catalyzed by TrdE, a Glycoside Hydrolase Family Enzyme

(2012) Xuhua Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nature-Inspired Total Synthesis of (−)-Fusarisetin A

(2012) Jing Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aurantoside K, a New Antifungal Tetramic Acid Glycoside from a Fijian Marine Sponge of the Genus Melophlus

(2012) Rohitesh Kumar et al.   Marine Drugs

First Total Synthesis of Epicoccarine A via O- to C-Acyl Rearrangement Strategy

(2012) Yasuaki Ujihara et al.   ORGANIC LETTERS

Mild Construction of 3-Methyl Tetramic Acids Enabling a Formal Synthesis of Palau’imide

(2012) Wen-Ju Bai et al.   ORGANIC LETTERS

Antiamoebic properties of the actinomycete metabolites echinomycin A and tirandamycin A

(2012) Avelina Espinosa et al.   PARASITOLOGY RESEARCH

3-Hydroxylation of the polycyclic tetramate macrolactam in the biosynthesis of antifungal HSAF from Lysobacter enzymogenes C3

(2012) Yaoyao Li et al.   MedChemComm

Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666

(2011) Xuhua Mo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pseurotin A1 and A2, two new 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-diones from the holothurian-derived fungus Aspergillus fumigatus WFZ-25

(2011) Fa-Zuo Wang et al.   CANADIAN JOURNAL OF CHEMISTRY

Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus

(2011) John W. Phillips et al.   CHEMISTRY & BIOLOGY

Total Synthesis, Stereochemical Assignment, and Antimalarial Activity of Gallinamide A

(2011) Trent Conroy et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tumor-selective amphiphilic para-quinones and tetramic acids

(2011) R. Schobert et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Reutericyclin and related analogues kill stationary phase Clostridium difficile at achievable colonic concentrations

(2011) J. G. Hurdle et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin in Streptomyces lydicus: Tailoring Modification of 3-Methyl-Aspartate

(2011) D. H. Horna et al.   JOURNAL OF BACTERIOLOGY

Amino Acid Precursor Supply in the Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin by Streptomyces lydicus

(2011) C. Gomez et al.   JOURNAL OF BACTERIOLOGY

The Fe(III) and Ga(III) coordination chemistry of 3-(1-hydroxymethylidene) and 3-(1-hydroxydecylidene)-5-(2-hydroxyethyl)pyrrolidine-2,4-dione: Novel tetramic acid degradation products of homoserine lactone bacterial quorum sensing molecules

(2011) Ariel A. Romano et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Chemical Synthesis Enables Biochemical and Antibacterial Evaluation of Streptolydigin Antibiotics

(2011) Sergey V. Pronin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (−)-Fusarisetin A and Reassignment of the Absolute Configuration of Its Natural Counterpart

(2011) Jun Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fusarisetin A, an Acinar Morphogenesis Inhibitor from a Soil Fungus, Fusarium sp. FN080326

(2011) Jae-Hyuk Jang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aurantoside J: a New Tetramic Acid Glycoside from Theonella swinhoei. Insights into the Antifungal Potential of Aurantosides

(2011) Rihab F. Angawi et al.   Marine Drugs

Roles of Pseudomonas aeruginosa Autoinducers and their Degradation Products, Tetramic acids, in Bacterial Survival and Behavior in Ecological Niches

(2011) Natsue Hosono Honda et al.   MICROBES AND ENVIRONMENTS

Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes

(2011) Jacob C. Carlson et al.   Nature Chemistry

Synthesis of the proposed structure of phaeosphaeride A

(2011) Kenichi Kobayashi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Total Synthesis of (−)-Tirandamycin C

(2011) Ming Chen et al.   ORGANIC LETTERS

Tirandamycins fromStreptomycessp. 17944 Inhibiting the ParasiteBrugia malayiAsparagine tRNA Synthetase

(2011) Zhiguo Yu et al.   ORGANIC LETTERS

Characterization ofTrdLas a 10-Hydroxy Dehydrogenase and Generation of New Analogues from a Tirandamycin Biosynthetic Pathway

(2011) Xuhua Mo et al.   ORGANIC LETTERS

Reactive oxygen species from chloroplasts contribute to 3-acetyl-5-isopropyltetramic acid-induced leaf necrosis of Arabidopsis thaliana

(2011) Shiguo Chen et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Two new hetero-spirocyclic γ-lactam derivatives from marine sediment-derived fungus Aspergillus sydowi D2–6

(2010) Hong Ren et al.   ARCHIVES OF PHARMACAL RESEARCH

Evaluation of Flavoglaucin, Its Derivatives and Pyranonigrins Produced by Molds Used in Fermented Foods for Inhibiting Tumor Promotion

(2010) Yoshiaki MIYAKE et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Identification of the Tirandamycin Biosynthetic Gene Cluster fromStreptomycessp. 307-9

(2010) Jacob C. Carlson et al.   CHEMBIOCHEM

The first enantioselective synthesis of cytotoxic marine natural product palau’imide and assignment of its C-20 stereochemistry

(2010) Hong-Qiao Lan et al.   CHEMICAL COMMUNICATIONS

A Selective 3-Acylation of Tetramic Acids and the First Synthesis of Ravenic Acid

(2010) Andrea Schlenk et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Flexible Asymmetric Approach to Methyl 5-Alkyltetramates and Its Application in the Synthesis of Cytotoxic Marine Natural Product Belamide A

(2010) Hong-Qiao Lan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Application of fast chlorophyll a fluorescence kinetics to probe action target of 3-acetyl-5-isopropyltetramic acid

(2010) Shiguo Chen et al.   ENVIRONMENTAL AND EXPERIMENTAL BOTANY

Total Synthesis of Tyrosine-Derived Tetramic Acid Pigments from a Slime Mould

(2010) Nassima Riache et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Biosynthesis of amycolamicin: the biosynthetic origin of a branched α-aminoethyl moiety in the unusual sugar amycolose

(2010) Shigehiro Tohyama et al.   JOURNAL OF ANTIBIOTICS

Inhibitory activity of blasticidin A, a strong aflatoxin production inhibitor, on protein synthesis of yeast: selective inhibition of aflatoxin production by protein synthesis inhibitors

(2010) Tomoya Yoshinari et al.   JOURNAL OF ANTIBIOTICS

Ophiosetin, a new tetramic acid derivative from the mycopathogenic fungus Elaphocordyceps ophioglossoides

(2010) Sastia Prama Putri et al.   JOURNAL OF ANTIBIOTICS

Pyridone and Tetramic Acid Alkaloids from the Spider Pathogenic FungusTorrubiellasp. BCC 2165

(2010) Masahiko Isaka et al.   JOURNAL OF NATURAL PRODUCTS

JBIR-22, An Inhibitor for Protein−Protein Interaction of the Homodimer of Proteasome Assembly Factor 3

(2010) Miho Izumikawa et al.   JOURNAL OF NATURAL PRODUCTS

Toward the Macrocidins: Macrocyclization via Williamson Etherification of a Phenolate

(2010) Bertram Barnickel et al.   JOURNAL OF ORGANIC CHEMISTRY

The Relationship between the CD Cotton Effect and the Absolute Configuration of FD-838 and Its Seven Stereoisomers

(2010) Takeshi Yamada et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Streptolydigin, a Potent Bacterial RNA Polymerase Inhibitor

(2010) Sergey V. Pronin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis and Antimalarial Activity of Symplostatin 4

(2010) Trent Conroy et al.   ORGANIC LETTERS

Direct Assignment of the Relative Configuration in 1,3,n-Methyl-Branched Carbon Chains by1H NMR Spectroscopy

(2010) Yvonne Schmidt et al.   ORGANIC LETTERS

Synthesis of the Tetracyclic Core of Tetrapetalone A Enabled by a Pyrrole Reductive Alkyation

(2010) Andrew P. Marcus et al.   ORGANIC LETTERS

Targeted Discovery of Polycyclic Tetramate Macrolactams from an EnvironmentalStreptomycesStrain

(2010) Shugeng Cao et al.   ORGANIC LETTERS

Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria

(2010) J. A. V. Blodgett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-Clostridium difficile Potential of Tetramic Acid Derivatives from Pseudomonas aeruginosa Quorum-Sensing Autoinducers

(2009) C. Ueda et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of Analogs of Reutericyclin as Prospective Candidates for Treatment of Staphylococcal Skin Infections

(2009) J. G. Hurdle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pseurotin A and its analogues as inhibitors of immunoglobuline E production

(2009) Minoru Ishikawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Combinatorial Strategies by Marine Cyanobacteria: Symplostatin 4, an Antimitotic Natural Dolastatin 10/15 Hybrid that Synergizes with the Coproduced HDAC Inhibitor Largazole

(2009) Kanchan Taori et al.   CHEMBIOCHEM

Deciphering Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin and Generation of Glycosylated Derivatives

(2009) Carlos Olano et al.   CHEMISTRY & BIOLOGY

Movento®, an innovative ambimobile insecticide for sucking insect pest control in agriculture: Biological profile and field performance

(2009) Ernst Brück et al.   CROP PROTECTION

Antimalarial Peptides from Marine Cyanobacteria: Isolation and Structural Elucidation of Gallinamide A

(2009) Roger G. Linington et al.   JOURNAL OF NATURAL PRODUCTS

Pyrrolidinones from the Ascomycete FungusAlbonectria rigidiuscula

(2009) Jian Li et al.   JOURNAL OF NATURAL PRODUCTS

Harzianic Acid, an Antifungal and Plant Growth Promoting Metabolite fromTrichoderma harzianum

(2009) Francesco Vinale et al.   JOURNAL OF NATURAL PRODUCTS

Isolation and Characterization of Tirandamycins from a Marine-DerivedStreptomycessp.

(2009) Jacob C. Carlson et al.   JOURNAL OF NATURAL PRODUCTS

A Convergent Route for the Total Synthesis of Malyngamides O, P, Q, and R

(2009) Jie Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Defining the Mode of Action of Tetramic Acid Antibacterials Derived from Pseudomonas aeruginosa Quorum Sensing Signals

(2009) Colin A. Lowery et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic Study on Tetrapetalones: Stereoselective Cyclization ofN-Acyliminium Ion To Construct Substituted 1-Benzazepines

(2009) Cheng Li et al.   ORGANIC LETTERS

Tetramic and tetronic acids: An update on new derivatives and biological aspects

(2008) Rainer Schobert et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antioxidative Pyranonigrins in Rice Mold Starters and Their Suppressive Effect on the Expression of Blood Adhesion Molecules

(2008) Yoshiaki MIYAKE et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation

(2008) Yukihiro Asami et al.   CANCER SCIENCE

Synthesis and Biological Properties of Cylindramide Derivatives: Evidence for Calcium-Dependent Cytotoxicity of Tetramic Acid Lactams

(2008) Nicolai Cramer et al.   CHEMBIOCHEM

Penicillenols from Penicillium sp. GQ-7, an Endophytic Fungus Associated with Aegiceras corniculatum

(2008) Zhen-Jian Lin et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

First Syntheses of Melophlins P, Q, and R, and Effects of Melophlins on the Growth of Microorganisms and Tumor Cells

(2008) Bernhard Biersack et al.   CHEMISTRY & BIODIVERSITY

Metal complexes of natural melophlins and their cytotoxic and antibiotic activities

(2008) B BIERSACK et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Isolation, Structure Elucidation, and Biological Activity of Virgineone fromLachnum virgineumUsing the Genome-WideCandida albicansFitness Test

(2008) John Ondeyka et al.   JOURNAL OF NATURAL PRODUCTS

Sintokamides A to E, Chlorinated Peptides from the SpongeDysideasp. that Inhibit Transactivation of the N-Terminus of the Androgen Receptor in Prostate Cancer Cells

(2008) Marianne D. Sadar et al.   ORGANIC LETTERS

Cytotoxic and antiplasmodial substances from marine-derived fungi, Nodulisporium sp. and CRI247-01

(2008) Chairut Kasettrathat et al.   PHYTOCHEMISTRY

An Antibiotic Complex fromLysobacter enzymogenesStrain C3: Antimicrobial Activity and Role in Plant Disease Control

(2008) S. Li et al.   PHYTOPATHOLOGY

Towards the total synthesis of FD-838: modular enantioselective assembly of the core

(2007) Arturo Orellana et al.   CHEMICAL COMMUNICATIONS