期刊
ORGANIC LETTERS
卷 12, 期 20, 页码 4652-4654出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol1020064
关键词
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资金
- NIH [GM086258]
- Harvard NERCE [A1057159, CA024487]
- Harvard Microbial Science Initiative Postdoctoral Fellowship
A targeted polymerase chain reaction (PCR)-based screening approach was used to identify candidate polycyclic tetramate macrolactam (PTM) biosynthetic gene clusters in environmental Streptomyces isolates. Isolation and characterization of the small molecules produced by one of the strains confirmed the production of two new PTMs (clifednamides A, 4, and B, 5) and, more generally, the utility of using a targeted approach for the discovery of new members of this interesting class
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