标题
Regulatory mechanisms of incomplete huntingtin mRNA splicing
作者
关键词
-
出版物
Nature Communications
Volume 9, Issue 1, Pages -
出版商
Springer Nature America, Inc
发表日期
2018-09-21
DOI
10.1038/s41467-018-06281-3
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Comparison of spinocerebellar ataxia type 3 mouse models identifies early gain-of-function, cell-autonomous transcriptional changes in oligodendrocytes
- (2017) Biswarathan Ramani et al. HUMAN MOLECULAR GENETICS
- Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study
- (2017) Davina J Hensman Moss et al. LANCET NEUROLOGY
- Salmon provides fast and bias-aware quantification of transcript expression
- (2017) Rob Patro et al. NATURE METHODS
- Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation
- (2017) Haifei Xu et al. PLoS One
- Alterations in mRNA 3′ UTR Isoform Abundance Accompany Gene Expression Changes in Human Huntington’s Disease Brains
- (2017) Lindsay Romo et al. Cell Reports
- Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing
- (2016) Tassa Saldi et al. JOURNAL OF MOLECULAR BIOLOGY
- Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice
- (2016) Peter Langfelder et al. NATURE NEUROSCIENCE
- Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut
- (2016) N. J. Proudfoot SCIENCE
- Native Elongating Transcript Sequencing Reveals Human Transcriptional Activity at Nucleotide Resolution
- (2015) Andreas Mayer et al. CELL
- Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing
- (2015) Takayuki Nojima et al. CELL
- Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease
- (2015) Jong-Min Lee et al. CELL
- The roles of CRISPR–Cas systems in adaptive immunity and beyond
- (2015) Rodolphe Barrangou CURRENT OPINION IN IMMUNOLOGY
- SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice
- (2015) James Palacino et al. Nature Chemical Biology
- CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II–transcribed genes
- (2015) Clélia Laitem et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- limma powers differential expression analyses for RNA-sequencing and microarray studies
- (2015) Matthew E. Ritchie et al. NUCLEIC ACIDS RESEARCH
- Discovery of Novel Isoforms of Huntingtin Reveals a New Hominid-Specific Exon
- (2015) Albert Ruzo et al. PLoS One
- CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II–transcribed genes
- (2015) Clélia Laitem et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Huntington disease
- (2015) Gillian P. Bates et al. Nature Reviews Disease Primers
- MYB Elongation Is Regulated by the Nucleic Acid Binding of NFκB p50 to the Intronic Stem-Loop Region
- (2015) Lloyd A. Pereira et al. PLoS One
- Evidence of Extensive Alternative Splicing in Post Mortem Human Brain HTT Transcription by mRNA Sequencing
- (2015) Adam T. Labadorf et al. PLoS One
- Mechanisms of transcriptional dysregulation in repeat expansion disorders
- (2014) Matthias Groh et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript
- (2014) Biswarathan Ramani et al. HUMAN MOLECULAR GENETICS
- Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease
- (2014) Brett A. Barbaro et al. HUMAN MOLECULAR GENETICS
- Novel Isoforms of Heat Shock Transcription Factor 1, HSF1γα and HSF1γβ, Regulate Chaperone Protein Gene Transcription
- (2014) Andreas Neueder et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of Novel Alternative Splicing Events in the Huntingtin Gene and Assessment of the Functional Consequences Using Structural Protein Homology Modelling
- (2014) Alis C. Hughes et al. JOURNAL OF MOLECULAR BIOLOGY
- SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy
- (2014) N. A. Naryshkin et al. SCIENCE
- Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing
- (2013) Vincent C. Auyeung et al. CELL
- Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
- (2013) Albert W Cheng et al. CELL RESEARCH
- Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS
- (2013) Hirokazu Hara et al. FEBS Journal
- ThesldGenetic Defect
- (2013) Biswadip Das et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease
- (2013) K. Sathasivam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aberrantly splicedHTT,a new player in Huntington’s disease pathogenesis
- (2013) Theresa A Gipson et al. RNA Biology
- Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches
- (2013) Ricardo Mouro Pinto et al. PLoS Genetics
- MSH3 Polymorphisms and Protein Levels Affect CAG Repeat Instability in Huntington's Disease Mice
- (2013) Stéphanie Tomé et al. PLoS Genetics
- Spt4 Is Selectively Required for Transcription of Extended Trinucleotide Repeats
- (2012) Chia-Rung Liu et al. CELL
- Transcription Elongation and Tissue-Specific Somatic CAG Instability
- (2012) Agathi-Vasiliki Goula et al. PLoS Genetics
- Splicing-Dependent RNA Polymerase Pausing in Yeast
- (2010) Ross D. Alexander et al. MOLECULAR CELL
- Global Analysis of Nascent RNA Reveals Transcriptional Pausing in Terminal Exons
- (2010) Fernando Carrillo Oesterreich et al. MOLECULAR CELL
- Splice Isoforms of the Polyglutamine Disease Protein Ataxin-3 Exhibit Similar Enzymatic yet Different Aggregation Properties
- (2010) Ginny Marie Harris et al. PLoS One
- KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents
- (2010) K. Yoshikiyo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex
- (2010) A. Missra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- R loops stimulate genetic instability of CTG{middle dot}CAG repeats
- (2009) Y. Lin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More