Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

(2013) K. Sathasivam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TR-FRET-Based Duplex Immunoassay Reveals an Inverse Correlation of Soluble and Aggregated Mutant huntingtin in Huntington's Disease

(2012) Barbara Baldo et al.   CHEMISTRY & BIOLOGY

Huntingtin Aggregation Kinetics and Their Pathological Role in a Drosophila Huntington’s Disease Model

(2011) Kurt R. Weiss et al.   GENETICS

Protein Misfolding Detected Early in Pathogenesis of Transgenic Mouse Model of Huntington Disease Using Amyloid Seeding Assay

(2011) Sharad Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What have we learned from gene expression profiles in Huntington's disease?

(2011) Tamara Seredenina et al.   NEUROBIOLOGY OF DISEASE

A Two-Step Path to Inclusion Formation of Huntingtin Peptides Revealed by Number and Brightness Analysis

(2010) Giulia Ossato et al.   BIOPHYSICAL JOURNAL

Proteolysis of Mutant Huntingtin Produces an Exon 1 Fragment That Accumulates as an Aggregated Protein in Neuronal Nuclei in Huntington Disease

(2010) Christian Landles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons

(2009) C. Sinadinos et al.   NEUROBIOLOGY OF DISEASE