Smurf1-Mediated Lys29-Linked Nonproteolytic Polyubiquitination of Axin Negatively Regulates Wnt/ -Catenin Signaling

HectD1 E3 Ligase Modifies Adenomatous Polyposis Coli (APC) with Polyubiquitin to Promote the APC-Axin Interaction

(2013) Hoanh Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction

(2013) Sheng Wang et al.   Nature Chemical Biology

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Smurf1 Protein Negatively Regulates Interferon-γ Signaling through Promoting STAT1 Protein Ubiquitination and Degradation

(2012) Chao Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein

(2012) W. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

(2012) Yogesh Kulathu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cdh1 Regulates Osteoblast Function through an APC/C-Independent Modulation of Smurf1

(2011) Lixin Wan et al.   MOLECULAR CELL

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

(2011) Yue Zhang et al.   NATURE CELL BIOLOGY

Phosphorylation of E3 Ligase Smurf1 Switches Its Substrate Preference in Support of Axon Development

(2011) Pei-lin Cheng et al.   NEURON

The various roles of ubiquitin in Wnt pathway regulation

(2010) Daniele V. F. Tauriello et al.   CELL CYCLE

The Protein Stability of Axin, a Negative Regulator of Wnt Signaling, Is Regulated by Smad Ubiquitination Regulatory Factor 2 (Smurf2)

(2010) Sewoon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The EDD E3 ubiquitin ligase ubiquitinates and up-regulates β-catenin

(2010) Avital Hay-Koren et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of the Tumor Suppressor CYLD Enhances Wnt/β-Catenin Signaling through K63-Linked Ubiquitination of Dvl

(2010) Daniele V.F. Tauriello et al.   MOLECULAR CELL

Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases

(2009) Masahiro Narimatsu et al.   CELL

Identification of Zinc-finger BED Domain-containing 3 (Zbed3) as a Novel Axin-interacting Protein That Activates Wnt/β-Catenin Signaling

(2009) Ting Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smad6 Inhibits the Transcriptional Activity of Tbx6 by Mediating Its Degradation

(2009) Yue-Lei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts

(2009) Nobuhiro Kamiya et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation

(2009) Shan Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

Smurf2 Induces Ubiquitin-dependent Degradation of Smurf1 to Prevent Migration of Breast Cancer Cells

(2008) Erina Fukunaga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation

(2008) Yu Ding et al.   JOURNAL OF CELL BIOLOGY

The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint

(2008) Evan C. Osmundson et al.   JOURNAL OF CELL BIOLOGY

BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/β-catenin signalling

(2008) Ni Tang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 Phosphorylation

(2008) W. Pan et al.   SCIENCE