Organocatalytic Enantioselective Cascade Aza-Michael/Michael Addition Sequence for Asymmetric Synthesis of Chiral Spiro[pyrrolidine-3,3′-oxindole]s

Bifunctional Amine-Squaramides: Powerful Hydrogen-Bonding Organocatalysts for Asymmetric Domino/Cascade Reactions

(2015) Pankaj Chauhan et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Takuya Hashimoto et al.   CHEMICAL REVIEWS

Organocatalytic Enamine-Activation of Cyclopropanes for Highly Stereoselective Formation of Cyclobutanes

(2015) Kim Søholm Halskov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis

(2014) Rishikesh Narayan et al.   ACCOUNTS OF CHEMICAL RESEARCH

PyBidine-Cu(OTf)2-Catalyzed Asymmetric [3+2] Cycloaddition with Imino Esters: Harmony of Cu-Lewis Acid and Imidazolidine-NH Hydrogen Bonding in Concerto Catalysis

(2014) Takayoshi Arai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective Construction of Polycyclic Spirooxindoles by Organocatalytic 1,3-Dipolar Cycloaddition of 2-Cyclohexenone Catalyzed by Proline-Sulfonamide

(2014) Jun-An Xiao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Asymmetric Synthesis of Functionalized 1,3,5-Triarylpyrrolidin-2-ones via an Aza-Michael/Aldol Domino Reaction

(2014) Dieter Enders et al.   SYNTHESIS-STUTTGART

Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies

(2014) Daojuan Cheng et al.   ACS Catalysis

Organocatalytic Enantioselective Cascade Aza-Michael/Michael Addition for the Synthesis of Highly Functionalized Tetrahydroquinolines and Tetrahydrochromanoquinolines

(2013) Wen Yang et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Aza-Henry Reaction of Imines Bearing a Benzothiazole Moiety Catalyzed by aCinchona-Based Squaramide

(2013) Hai-Xiao He et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Synthesis of Functionalized Tetrahydronaphthalenesviaan Organocatalytic Nitroalkane-Michael/Henry Domino Reaction

(2013) Dieter Enders et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent Advances in Asymmetric Organocatalytic Construction of 3,3′-Spirocyclic Oxindoles

(2013) Liang Hong et al.   ADVANCED SYNTHESIS & CATALYSIS

Efficient construction of highly functionalized spiro[γ-butyrolactone-pyrrolidin-3,3′-oxindole] tricyclic skeletons via an organocatalytic 1,3-dipolar cycloaddition

(2013) Long Wang et al.   CHEMICAL COMMUNICATIONS

Cinchona-based squaramide-catalysed cascade aza-Michael–Michael addition: enantioselective construction of functionalized spirooxindole tetrahydroquinolines

(2013) Wen Yang et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric multicomponent cascade reaction via 1,3-proton shift and [3+2] cycloaddition: an efficient strategy for the synthesis of oxindole derivatives

(2013) Li Tian et al.   CHEMICAL COMMUNICATIONS

Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene

(2013) Xiaowei Dou et al.   CHEMICAL COMMUNICATIONS

Catalytic C–C Bond-Forming Multi-Component Cascade or Domino Reactions: Pushing the Boundaries of Complexity in Asymmetric Organocatalysis

(2013) Chandra M. R. Volla et al.   CHEMICAL REVIEWS

Organocatalytic Asymmetric Synthesis of Tetracyclic Pyridocarbazole Derivatives by Using a Diels-Alder/aza-Michael/Aldol Condensation Domino Reaction

(2013) Dieter Enders et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantioselective Organocatalytic Michael Addition/Cyclization Cascade Reaction of Ylideneoxindoles with Isothiocyanato Oxindoles: A Formal [3+2] Cycloaddition Approach to Optically Active Bispirooxindole Derivatives

(2013) Fen Tan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Synthesis of Chiral Pyrrolizine-Based Triheterocycles by Organocatalytic Cascade Aza-Michael-Aldol Reactions

(2013) Hyo-Jun Lee et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Chiral squaramide-catalysed one-pot enantioselective sulfa-Michael addition/thioesterification of thiols with α,β-unsaturated N-acylated succinimides

(2013) Bo-Liang Zhao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An efficient, one-pot, three-component procedure for the synthesis of chiral spirooxindolopyrrolizidines via catalytic highly enantioselective 1,3-dipolar cycloaddition

(2013) Farbod Salahi et al.   TETRAHEDRON LETTERS

Recent Developments in Asymmetric Organocatalytic Domino Reactions

(2012) Hélène Pellissier   ADVANCED SYNTHESIS & CATALYSIS

An Organocatalytic Cascade Approach toward Polysubstituted Quinolines and Chiral 1,4-Dihydroquinolines-Unanticipated Effect of N-Protecting Groups

(2012) Xinshuai Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RhII2-Catalyzed Synthesis of α-, β-, or δ-Carbolines from Aryl Azides

(2012) Ashley L. Pumphrey et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

(2012) Renato Dalpozzo et al.   CHEMICAL SOCIETY REVIEWS

Organocatalytic Aza-Michael-Michael Cascade Reactions: A Flexible Approach to 2,3,4-Trisubstituted Tetrahydroquinolines

(2012) Zhen-Xin Jia et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Organocatalytic Cascade Strategy for the Enantioselective Construction of Spirocyclopentane Bioxindoles Containing Three Contiguous Stereocenters and Two Spiro Quaternary Centers

(2012) Wangsheng Sun et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Organocatalytic One-Pot Amination/aza-Michael/Aldol Condensation Reaction Sequence: Synthesis of 3-Pyrrolines with a Quaternary Stereocenter

(2012) Alaric Desmarchelier et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric exo′-Selective [3+2] Cycloaddition for Constructing Stereochemically Diversified Spiro[pyrrolidin-3,3′-oxindole]s

(2012) Atsuko Awata et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diastereodivergent Synthesis of 3-Spirocyclopropyl-2-oxindoles through Direct Enantioselective Cyclopropanation of Oxindoles

(2012) Xiaowei Dou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantio- and Diastereoselective Generation of Two Quaternary Centers in Spirocyclopropanation of Oxindole Derivatives.

(2012) Artur Noole et al.   CHEMISTRY-A EUROPEAN JOURNAL

Scaffold-Inspired Enantioselective Synthesis of Biologically Important Spiro[pyrrolidin-3,2′-oxindoles] with Structural Diversity through Catalytic Isatin-Derived 1,3-Dipolar Cycloadditions

(2012) Feng Shi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design

(2012) Ivan V. Efremov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bifuctional Amino-Squaramides Catalyzed Asymmetric Spiroannulation Cascades with Aliphatic β,γ-Unsaturated α-Keto Esters: Controlling an Aldehyde Enolate

(2012) Xiaoqin Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Organo-SOMO Cycloadditions: A Catalytic Approach to Complex Pyrrolidines from Olefins and Aldehydes

(2012) Nathan T. Jui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Welwitindolinone is well worth it

(2012) John L. Wood   Nature Chemistry

Assembly of Spirooxindole Derivatives Containing Four Consecutive Stereocenters via Organocatalytic Michael–Henry Cascade Reactions

(2012) Klaus Albertshofer et al.   ORGANIC LETTERS

Spiro-fused Pyrrolidine, Piperidine, and Oxindole Scaffolds from Lactams

(2012) Christoph Hirschhäuser et al.   ORGANIC LETTERS

Direct construction of novel exo′-selective spiropyrrolidine bisoxindoles via a three-component 1,3-dipolar cycloaddition reaction

(2012) Jie Liu et al.   TETRAHEDRON LETTERS

Brønsted-Acid-Catalyzed Asymmetric Multicomponent Reactions for the Facile Synthesis of Highly Enantioenriched Structurally Diverse Nitrogenous Heterocycles

(2011) Jie Yu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enantioselective Michael/Cyclization Reaction Sequence: Scaffold-Inspired Synthesis of Spirooxindoles with Multiple Stereocenters

(2011) Yiming Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic enantioselective synthesis of 2,3-dihydropyridazines

(2011) Maitane Fernández et al.   CHEMICAL COMMUNICATIONS

Squaramides: physical properties, synthesis and applications

(2011) R. Ian Storer et al.   CHEMICAL SOCIETY REVIEWS

Organocatalytic Michael-Alkylation Cascade: The Enantioselective Nitrocyclopropanation of Oxindoles

(2011) Fabio Pesciaioli et al.   CHEMISTRY-A EUROPEAN JOURNAL

Squaramides: Bridging from Molecular Recognition to Bifunctional Organocatalysis

(2011) José Alemán et al.   CHEMISTRY-A EUROPEAN JOURNAL

Core-Structure-Motivated Design of a Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles

(2011) Bin Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trienamines in Asymmetric Organocatalysis: Diels−Alder and Tandem Reactions

(2011) Zhi-Jun Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Asymmetric Construction of Spirocyclopentaneoxindoles by a Combined Ru-Catalyzed Cross-Metathesis/Double Michael Addition Sequence

(2011) Ying-Mei Li et al.   ORGANIC LETTERS

Highly Enantioselective Synthesis of Polysubstituted TetrahydroquinolinesviaOrganocatalytic Michael/Aza-Henry Tandem Reactions

(2011) Zhen-Xin Jia et al.   ORGANIC LETTERS

Asymmetic Organocatalytic 1,3-Dipolar Cycloaddition of Azomethine Ylide to Methyl 2-(2-Nitrophenyl)acrylate for the Synthesis of Diastereoisomers of Spirotryprostatin A

(2011) Mou-Nuo Cheng et al.   ORGANIC LETTERS

Enantioselective synthesis of the spirotryprostatin A scaffold

(2011) Andrey P. Antonchick et al.   TETRAHEDRON

Domino Pd-Catalyzed Heck Cyclization and Bismuth-Catalyzed Hydroamination: Formal Synthesis of Elacomine and Isoelacomine

(2010) Haruhi Kamisaki et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

(2010) Andrey P. Antonchick et al.   Nature Chemistry

Organocatalytic cascade reactions as a new tool in total synthesis

(2010) Christoph Grondal et al.   Nature Chemistry

Enantioselective synthesis of spirooxoindoles via chiral auxiliary (bicyclic lactam) controlled SNAr reactions

(2010) Subhabrata Sen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Catalytic asymmetric 1,3-dipolar cycloaddition of N-unprotected 2-oxoindolin-3-ylidene derivatives and azomethine ylides for the construction of spirooxindole-pyrrolidines

(2010) Tang-Lin Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric Quadruple Aminocatalytic Domino Reactions to Fused Carbocycles Incorporating a Spirooxindole Motif

(2010) Kun Jiang et al.   ORGANIC LETTERS

Organocatalytic Asymmetric Formal [4 + 2] Cycloaddition for the Synthesis of Spiro[4-cyclohexanone-1,3′-oxindoline] Derivatives in High Optical Purity

(2010) Qiang Wei et al.   ORGANIC LETTERS

Highly Enantioselective Construction of Spiro[4H-pyran-3,3′-oxindoles] Through a Domino Knoevenagel/Michael/Cyclization Sequence Catalyzed by Cupreine

(2010) Wen-Bing Chen et al.   ORGANIC LETTERS

Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

(2009) Giorgio Bencivenni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Domino Reactions

(2009) Andrea-Nekane Alba et al.   CURRENT ORGANIC CHEMISTRY

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

(2009) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Toward the improvement of the tandem halide displacement/amide coupling spiro-cyclization as a new route to γ-lactam and pyrroloisoquinoline templates

(2009) Iyad Allous et al.   TETRAHEDRON LETTERS

Highly enantio- and diastereoselective organocatalytic cascade aza-Michael–Michael reactions: a direct method for the synthesis of trisubstituted chiral pyrrolidines

(2008) Hao Li et al.   CHEMICAL COMMUNICATIONS

Evolution of a Synthetic Strategy:  Total Synthesis of (±)-Welwitindolinone A Isonitrile

(2008) Sarah E. Reisman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantiospecific Total Synthesis of the Hapalindoles, Fischerindoles, and Welwitindolinonesviaa Redox Economic Approach

(2008) Jeremy M. Richter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral Squaramide Derivatives are Excellent Hydrogen Bond Donor Catalysts

(2008) Jeremiah P. Malerich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalysis: asymmetric cascade reactions catalysed by chiral secondary amines

(2008) Xinhong Yu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

(2008) S. Shangary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA