期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 355, 期 6, 页码 1137-1148出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201200957
关键词
asymmetric catalysis; aza-Henry reaction; benzothiazoles; imines; organocatalysis; squaramides
资金
- National Natural Science Foundation of China [21072020, 21272024]
- Science and Technology Innovation Program of Beijing Institute of Technology [2011CX01008]
- Development Program for Distinguished Young and Middle-aged Teachers of Beijing Institute of Technology
An efficient enantioselective aza-Henry reaction of nitroalkanes to imines bearing a benzothiazole moiety catalyzed by a Cinchona-based squaramide has been developed. In the reaction of imines, the corresponding products were obtained in good to excellent yields (up to 99%) with excellent enantioselectivities (up to >99% ee) for most of the aromatic substituted imines. The imines with electron-withdrawing groups gave better yields than those bearing electron-donating groups in the aza-Henry reaction. Moreover, a one-pot three-component enantioselective aza-Henry reaction using 2-aminobenzothiazoles, aldehydes, and nitromethane was also developed. Moderate to good yields and high enantioselectivities were obtained in the one-pot cases (up to 98% ee).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据