Enantioselective Michael/Cyclization Reaction Sequence: Scaffold-Inspired Synthesis of Spirooxindoles with Multiple Stereocenters

Stereodivergent Direct Catalytic Asymmetric Mannich-Type Reactions of α-Isothiocyanato Ester with Ketimines

(2011) Gang Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Guanidine Organocatalyst for the Asymmetric Mannich-Type Reaction between α-Isothiocyanato Imide and Sulfonyl Imines

(2011) Xiaohong Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Core-Structure-Motivated Design of a Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles

(2011) Bin Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters

(2011) Wen-Bing Chen et al.   ORGANIC LETTERS

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic enantioselective aldol additions of α-isothiocyanato imides to α-ketoesters

(2010) Matthew K. Vecchione et al.   CHEMICAL COMMUNICATIONS

Highly diastereo- and enantioselective Mannich reaction of lactones with N-Boc-aldimines catalyzed by bifunctional rosin-derived amine thiourea catalysts

(2010) Xianxing Jiang et al.   CHEMICAL COMMUNICATIONS

Efficient Synthesis of β-Hydroxy-α-Amino Acid Derivatives via Direct Catalytic Asymmetric Aldol Reaction of α-Isothiocyanato Imide with Aldehydes

(2010) Xiaohong Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Unique Approach to the Concise Synthesis of Highly Optically Active Spirooxazolines and the Discovery of a More Potent Oxindole-Type Phytoalexin Analogue

(2010) Xianxing Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

(2010) Andrey P. Antonchick et al.   Nature Chemistry

Enantioselective synthesis of spirooxoindoles via chiral auxiliary (bicyclic lactam) controlled SNAr reactions

(2010) Subhabrata Sen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Direct Organocatalytic Asymmetric Aldol Reaction of α-Isothiocyanato Imides to α-Ketoesters under Low Ligand Loading: A Doubly Stereocontrolled Approach to Cyclic Thiocarbamates Bearing Chiral Quaternary Stereocenters†

(2010) Xianxing Jiang et al.   ORGANIC LETTERS

Attractive noncovalent interactions in asymmetric catalysis: Links between enzymes and small molecule catalysts

(2010) R. R. Knowles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organocatalytic Asymmetric Synthesis of Protected α,β-Diamino Acids

(2009) Zugui Shi et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of Natural Product Inspired Compound Collections

(2009) Kamal Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

(2009) Giorgio Bencivenni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantio- and Diastereoselective Asymmetric Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes in a Doubly Stereocontrolled Manner Catalyzed by Bifunctional Rosin-Derived Amine Thiourea Catalysts

(2009) Xianxing Jiang et al.   JOURNAL OF ORGANIC CHEMISTRY

Mechanism of Amido-Thiourea Catalyzed Enantioselective Imine Hydrocyanation: Transition State Stabilization via Multiple Non-Covalent Interactions

(2009) Stephan J. Zuend et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Enantioselective Synthesis of α,β-Diamino Acid Derivatives

(2009) Le Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Construction of Contiguous Tetrasubstituted Chiral Carbon Stereocenters via Direct Catalytic Asymmetric Aldol Reaction of α-Isothiocyanato Esters with Ketones

(2009) Tatsuhiko Yoshino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

(2009) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemistry and biology of non-tetramic γ-hydroxy-γ-lactams and γ-alkylidene-γ-lactams from natural sources

(2009) Bastien Nay et al.   NATURAL PRODUCT REPORTS

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

(2009) Barry Trost et al.   SYNTHESIS-STUTTGART

Toward the improvement of the tandem halide displacement/amide coupling spiro-cyclization as a new route to γ-lactam and pyrroloisoquinoline templates

(2009) Iyad Allous et al.   TETRAHEDRON LETTERS

Discovery of a New Class of Potent, Selective, and Orally Bioavailable CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases#

(2008) Stefano Crosignani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Catalytic Enantioselective Aldol Additions of α-Isothiocyanato Imides to Aldehydes

(2008) Le Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Enantioselective Synthesis of γ-Nitro Heteroaromatic Ketones in a Doubly Stereocontrolled Manner Catalyzed by Bifunctional Thiourea Catalysts Based on Dehydroabietic Amine: A Doubly Stereocontrolled Approach to Pyrrolidine Carboxylic Acids

(2008) Xianxing Jiang et al.   ORGANIC LETTERS