5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential

Labeling of Oxidizable Proteins with a Photoactivatable Analog of the Antitumor Agent DMXAA: Evidence for Redox Signaling in Its Mode of Action

(2015) Romy Brauer et al.   NEOPLASIA

Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulation

(2011) Jing Sun et al.   BIOCHEMICAL PHARMACOLOGY

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice

(2011) Juliane Lippmann et al.   CELLULAR MICROBIOLOGY

Characterization of Rubus fruticosus mitochondria and salicylic acid inhibition of reactive oxygen species generation at Complex III/Q cycle: potential implications for hypersensitive response in plants

(2011) Wagner Rodrigo de Souza et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Randomized Phase III Placebo-Controlled Trial of Carboplatin and Paclitaxel With or Without the Vascular Disrupting Agent Vadimezan (ASA404) in Advanced Non–Small-Cell Lung Cancer

(2011) Primo N. Lara et al.   JOURNAL OF CLINICAL ONCOLOGY

MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

(2011) L. Jin et al.   JOURNAL OF IMMUNOLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

MyD88 and STING Signaling Pathways Are Required for IRF3-Mediated IFN-β Induction in Response to Brucella abortus Infection

(2011) Leonardo A. de Almeida et al.   PLoS One

Mitochondrial Membrane Potential Is Required for MAVS-Mediated Antiviral Signaling

(2011) T. Koshiba et al.   Science Signaling

Pharmacologic Activation of the Innate Immune System to Prevent Respiratory Viral Infections

(2010) Guanjun Cheng et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Tom70 mediates activation of interferon regulatory factor 3 on mitochondria

(2010) Xin-Yi Liu et al.   CELL RESEARCH

N-acetylcysteine impairs survival of luteal cells through mitochondrial dysfunction

(2010) Berthold Löhrke et al.   CYTOMETRY PART A

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Activation of the Nucleotide Oligomerization Domain Signaling Pathway by the Non-bacterially Derived Xanthone Drug 5′6-Dimethylxanthenone-4-acetic Acid (Vadimezan)

(2010) Guanjun Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stimulator of IFN Gene Is Critical for Induction of IFN-β during Chlamydia muridarum Infection

(2010) Daniel Prantner et al.   JOURNAL OF IMMUNOLOGY

The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo

(2010) Kari Ann Shirey et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

(2010) J. W. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirement of NOX2 and Reactive Oxygen Species for Efficient RIG-I-Mediated Antiviral Response through Regulation of MAVS Expression

(2010) Anton Soucy-Faulkner et al.   PLoS Pathogens

Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

(2009) Céline Castanier et al.   EMBO REPORTS

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

(2009) Sarah M. McWhirter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phase II study of ASA404 (vadimezan, 5,6-dimethylxanthenone-4-acetic acid/DMXAA) 1800mg/m2 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer

(2009) Mark J. McKeage et al.   LUNG CANCER

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer

(2008) M J McKeage et al.   BRITISH JOURNAL OF CANCER

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

Role for the Chlamydial Type III Secretion Apparatus in Host Cytokine Expression

(2008) D. Prantner et al.   INFECTION AND IMMUNITY

Mitochondrial dysfunction by complex II inhibition delays overall cell cycle progression via reactive oxygen species production

(2008) Hae-Ok Byun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

IFN-β-Dependent Inhibition of Tumor Growth by the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid (DMXAA)

(2008) Zachary J. Roberts et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols