Identification and Proteomic Analysis of Distinct UBE3A/E6AP Protein Complexes

Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres

(2012) Ji Li et al.   EMBO REPORTS

Interaction Proteomics Identify NEURL4 and the HECT E3 Ligase HERC2 as Novel Modulators of Centrosome Architecture

(2012) Abdallah K. Al-Hakim et al.   MOLECULAR & CELLULAR PROTEOMICS

The Extracellular Signal-Regulated Kinase 3 (Mitogen-Activated Protein Kinase 6 [MAPK6])-MAPK-Activated Protein Kinase 5 Signaling Complex Regulates Septin Function and Dendrite Morphology

(2012) F. Brand et al.   MOLECULAR AND CELLULAR BIOLOGY

Cutaneous  -human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling

(2012) M. J. A. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses

(2012) E. A. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical and Functional Interaction of the HECT Ubiquitin-protein Ligases E6AP and HERC2

(2011) Simone Kühnle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3

(2011) S. Rahman et al.   MOLECULAR AND CELLULAR BIOLOGY

Defining human ERAD networks through an integrative mapping strategy

(2011) John C. Christianson et al.   NATURE CELL BIOLOGY

Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins

(2011) Nancy N. Fang et al.   NATURE CELL BIOLOGY

Angelman Syndrome Protein UBE3A Interacts with Primary Microcephaly Protein ASPM, Localizes to Centrosomes and Regulates Chromosome Segregation

(2011) Pooja Singhmar et al.   PLoS One

Increased Gene Dosage of Ube3a Results in Autism Traits and Decreased Glutamate Synaptic Transmission in Mice

(2011) S. E. P. Smith et al.   Science Translational Medicine

Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes

(2011) Angela M. Mabb et al.   TRENDS IN NEUROSCIENCES

The behavioral phenotype of the Angelman syndrome

(2010) Charles A. Williams   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc

(2010) Paul L. Greer et al.   CELL

Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines

(2010) Baris Bingol et al.   CELL

A functional link between the human cell cycle-regulatory phosphatase Cdc14A and the atypical mitogen-activated kinase Erk3

(2010) Christina Aaen Hansen et al.   CELL CYCLE

‘Puppet’ Children A Report on Three Cases

(2010) Harry Angelman   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Clinical and genetic aspects of Angelman syndrome

(2010) Charles A Williams et al.   GENETICS IN MEDICINE

E6AP ubiquitin ligase mediates ubiquitin-dependent degradation of peroxiredoxin 1

(2010) Junichi Nasu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Parkin Directly Modulates 26S Proteasome Activity

(2010) J. W. Um et al.   JOURNAL OF NEUROSCIENCE

NCoR1 Mediates Papillomavirus E8^E2C Transcriptional Repression

(2010) M. L. C. Powell et al.   JOURNAL OF VIROLOGY

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

ERK3 Is Required for Metaphase-Anaphase Transition in Mouse Oocyte Meiosis

(2010) Sen Li et al.   PLoS One

Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome

(2010) D. Zaaroor-Regev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of UBE3A and ATP10A genes in autism susceptibility region 15q11-q13 in an Italian population: A positive replication for UBE3A

(2010) Guia Guffanti et al.   PSYCHIATRY RESEARCH

FIH-Dependent Asparaginyl Hydroxylation of Ankyrin Repeat Domain-Containing Proteins

(2009) Matthew E. Cockman et al.   Annals of the New York Academy of Sciences

Isolation of Mammalian 26S Proteasomes and p97/VCP Complexes Using the Ubiquitin-like Domain from HHR23B Reveals Novel Proteasome-Associated Proteins†

(2009) Henrike C. Besche et al.   BIOCHEMISTRY

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

E6AP promotes the degradation of the PML tumor suppressor

(2009) I Louria-Hayon et al.   CELL DEATH AND DIFFERENTIATION

Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta

(2009) Joseph R. Fontana et al.   DEVELOPMENTAL BIOLOGY

The Ubiquitin Ligase E6-AP Is Induced and Recruited to Aggresomes in Response to Proteasome Inhibition and May Be Involved in the Ubiquitination of Hsp70-bound Misfolded Proteins

(2009) Amit Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of annexin A1 as a novel substrate for E6AP-mediated ubiquitylation

(2009) Tetsu Shimoji et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

E6 Proteins from Diverse Papillomaviruses Self-Associate Both In Vitro and In Vivo

(2009) Katia Zanier et al.   JOURNAL OF MOLECULAR BIOLOGY

The Ubiquitin-Specific Peptidase USP15 Regulates Human Papillomavirus Type 16 E6 Protein Stability

(2009) R. M. Vos et al.   JOURNAL OF VIROLOGY

The Ubiquitin Ligase Hul5 Promotes Proteasomal Processivity

(2009) S. Aviram et al.   MOLECULAR AND CELLULAR BIOLOGY

The many faces of the SOCS box

(2008) Julie Piessevaux et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Isolation of human proteasomes and putative proteasome-interacting proteins using a novel affinity chromatography method

(2008) Thomas C. Scanlon et al.   EXPERIMENTAL CELL RESEARCH

E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6

(2008) Li Zheng et al.   GENES TO CELLS

E6-AP Promotes Misfolded Polyglutamine Proteins for Proteasomal Degradation and Suppresses Polyglutamine Protein Aggregation and Toxicity

(2008) Amit Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomics-based Identification of Novel Factor Inhibiting Hypoxia-inducible Factor (FIH) Substrates Indicates Widespread Asparaginyl Hydroxylation of Ankyrin Repeat Domain-containing Proteins

(2008) Matthew E. Cockman et al.   MOLECULAR & CELLULAR PROTEOMICS

Protein unfolding by a AAA+ protease is dependent on ATP-hydrolysis rates and substrate energy landscapes

(2008) Andreas Martin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY